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The Alborz range of N Iran provides key information on the spatiotemporal evolution and characteristics of the Arabia-Eurasia continental collision zone. The southwestern Alborz range constitutes a transpressional duplex, which accommodates oblique shortening between Central Iran and the South Caspian Basin. The duplex comprises NW-striking frontal ramps that are kinematically linked to inherited E-W-striking, right-stepping lateral to obliquely oriented ramps. New zircon and apatite (U-Th)/He data provide a high-resolution framework to unravel the evolution of collisional tectonics in this region. Our data record two pulses of fast cooling associated with SW-directed thrusting across the frontal ramps at similar to 18-14 and 9.5-7.5 Ma, resulting in the tectonic repetition of a fossil zircon partial retention zone and a cooling pattern with a half U-shaped geometry. Uniform cooling ages of similar to 7-6 Ma along the southernmost E-W striking oblique ramp and across its associated NW-striking frontal ramps suggests that the ramp was reactivated as a master throughgoing, N-dipping thrust. We interpret this major change in fault kinematics and deformation style to be related to a change in the shortening direction from NE to N/NNE. The reduction in the obliquity of thrusting may indicate the termination of strike-slip faulting (and possibly thrusting) across the Iranian Plateau, which could have been triggered by an increase in elevation. Furthermore, we suggest that similar to 7-6-m.y.-old S-directed thrusting predated inception of the westward motion of the South Caspian Basin. Citation: Ballato, P., D. F. Stockli, M. R. Ghassemi, A. Landgraf, M. R. Strecker, J. Hassanzadeh, A. Friedrich, and S. H. Tabatabaei (2012), Accommodation of transpressional strain in the Arabia-Eurasia collision zone: new constraints from (U-Th)/He thermochronology in the Alborz mountains.
From 6 to 9 August 2012, intense rainfall hit the northern Philippines, causing massive floods in Metropolitan Manila and nearby regions. Local rain gauges recorded almost 1000mm within this period. However, the recently installed Philippine network of weather radars suggests that Metropolitan Manila might have escaped a potentially bigger flood just by a whisker, since the centre of mass of accumulated rainfall was located over Manila Bay. A shift of this centre by no more than 20 km could have resulted in a flood disaster far worse than what occurred during Typhoon Ketsana in September 2009.
The objectives of the present investigation are (i) to study the effects of climate change on precipitation extremes and (ii) to assess the uncertainty in the climate projections. The investigation is performed on the Lech catchment, located in the Northern Limestone Alps. In order to estimate the uncertainty in the climate projections, two statistical downscaling models as well as a number of global and regional climate models were considered. The downscaling models applied are the Expanded Downscaling (XDS) technique and the Long Ashton Research Station Weather Generator (LARS-WG). The XDS model, which is driven by analyzed or simulated large-scale synoptic fields, has been calibrated using ECMWF-interim reanalysis data and local station data. LARS-WG is controlled through stochastic parameters representing local precipitation variability, which are calibrated from station data only. Changes in precipitation mean and variability as simulated by climate models were then used to perturb the parameters of LARS-WG in order to generate climate change scenarios. In our study we use climate simulations based on the A1B emission scenario. The results show that both downscaling models perform well in reproducing observed precipitation extremes. In general, the results demonstrate that the projections are highly variable. The choice of both the GCM and the downscaling method are found to be essential sources of uncertainty. For spring and autumn, a slight tendency toward an increase in the intensity of future precipitation extremes is obtained, as a number of simulations show statistically significant increases in the intensity of 90th and 99th percentiles of precipitation on wet days as well as the 5- and 20-yr return values.
We study origin, parameter optimization, and thermodynamic efficiency of isothermal rocking ratchets based on fractional subdiffusion within a generalized non-Markovian Langevin equation approach. A corresponding multi-dimensional Markovian embedding dynamics is realized using a set of auxiliary Brownian particles elastically coupled to the central Brownian particle (see video on the journal web site). We show that anomalous subdiffusive transport emerges due to an interplay of nonlinear response and viscoelastic effects for fractional Brownian motion in periodic potentials with broken space-inversion symmetry and driven by a time-periodic field. The anomalous transport becomes optimal for a subthreshold driving when the driving period matches a characteristic time scale of interwell transitions. It can also be optimized by varying temperature, amplitude of periodic potential and driving strength. The useful work done against a load shows a parabolic dependence on the load strength. It grows sublinearly with time and the corresponding thermodynamic efficiency decays algebraically in time because the energy supplied by the driving field scales with time linearly. However, it compares well with the efficiency of normal diffusion rocking ratchets on an appreciably long time scale.
In various biological systems and small scale technological applications particles transiently bind to a cylindrical surface. Upon unbinding the particles diffuse in the vicinal bulk before rebinding to the surface. Such bulk-mediated excursions give rise to an effective surface translation, for which we here derive and discuss the dynamic equations, including additional surface diffusion. We discuss the time evolution of the number of surface-bound particles, the effective surface mean squared displacement, and the surface propagator. In particular, we observe sub- and superdiffusive regimes. A plateau of the surface mean-squared displacement reflects a stalling of the surface diffusion at longer times. Finally, the corresponding first passage problem for the cylindrical geometry is analysed.
The ability of some chemical compounds to cause oxidative stress offers a fast and convenient way to study the responses of plants to reactive oxygen species (ROS). In order to unveil potential novel genetic players of the ROS-regulatory network, a population of similar to 2,000 randomly selected Arabidopsis thaliana T-DNA insertion mutants was screened for ROS sensitivity/resistance by growing seedlings on agar medium supplemented with stress-inducing concentrations of the superoxide-eliciting herbicide methyl viologen or the catalase inhibitor 3-amino-triazole. A semi-robotic setup was used to capture and analyze images of the chemically treated seedlings which helped interpret the screening results by providing quantitative information on seedling area and healthy-to-chlorotic tissue ratios for data verification. A ROS-related phenotype was confirmed in three of the initially selected 33 mutant candidates, which carry T-DNA insertions in genes encoding a Ring/Ubox superfamily protein, ABI5 binding protein 1 (AFP1), previously reported to be involved in ABA signaling, and a protein of unknown function, respectively. In addition, we identified six mutants, most of which have not been described yet, that are related to growth or chloroplast development and show defects in a ROS-independent manner. Thus, semi-automated image capturing and phenotyping applied on publically available T-DNA insertion collections adds a simple means for discovering novel mutants in complex physiological processes and identifying the genes involved.
4-Phenol diazonium salts undergo Pd-catalyzed Heck reactions with various styrenes to 4'-hydroxy stilbenes. In almost all cases higher yields and fewer side products were observed, compared to the analogous 4-methoxy benzene diazonium salts. In contrast, the reaction fails completely with 2- and 3-phenol diazonium salts. For these substitution patterns the methoxy-substituted derivatives are superior.
Silver nanoparticles (SNP) are among the most commercialized nanoparticles. Here, we show that peptide-coated SNP cause functional impairment of human macrophages. A dose-dependent inhibition of phagocytosis is observed after nanoparticle treatment, and pretreatment of cells with N-acetyl cysteine (NAC) can counteract the phagocytosis disturbances caused by SNP.
Using the surface-sensitive mode of time-of-flight secondary ion mass spectrometry, in combination with multivariate statistical methods, we studied the composition of cell membranes in human macrophages upon exposure to SNP with and without NAC preconditioning. This method revealed characteristic changes in the lipid pattern of the cellular membrane outer leaflet in those cells challenged by SNP. Statistical analyses resulted in 19 characteristic ions, which can be used to distinguish between NAC pretreated and untreated macrophages. The present study discusses the assignments of surface cell membrane phospholipids for the identified ions and the resulting changes in the phospholipid pattern of treated cells. We conclude that the adverse effects in human macrophages caused by SNP can be partially reversed through NAC administration. Some alterations, however, remained.
Silver nanoparticles (SNPs) are among the most commercialized nanoparticles because of their antibacterial effects. Besides being employed, e. g. as a coatingmaterial for sterile surfaces in household articles and appliances, the particles are also used in a broad range of medical applications. Their antibacterial properties make SNPs especially useful for wound disinfection or as a coating material for prostheses and surgical instruments. Because of their optical characteristics, the particles are of increasing interest in biodetection as well. Despite the widespread use of SNPs, there is little knowledge of their toxicity. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) and laser post-ionization secondary neutral mass spectrometry (Laser-SNMS) were used to investigate the effects of SNPs on human macrophages derived from THP-1 cells in vitro. For this purpose, macrophages were exposed to SNPs. The SNP concentration ranges were chosen with regard to functional impairments of the macrophages. To optimize the analysis of the macrophages, a special silicon wafer sandwich preparation technique was employed; ToF-SIMS was employed to characterize fragments originating from macrophage cell membranes. With the use of this optimized sample preparation method, the SNP-exposed macrophages were analyzed with ToF-SIMS and with Laser-SNMS. With Laser-SNMS, the three-dimensional distribution of SNPs in cells could be readily detected with very high efficiency, sensitivity, and submicron lateral resolution. We found an accumulation of SNPs directly beneath the cell membrane in a nanoparticular state as well as agglomerations of SNPs inside the cells.
Cross metathesis of allyl alcohols how to suppress and how to promote double bond isomerization
(2013)
Under standard conditions the cross metathesis of allyl alcohols and methyl acrylate is accompanied by the formation of ketones, resulting from uncontrolled and undesired double bond isomerization. By conducting the CM in the presence of phenol, the catalyst loading and the reaction time required for quantiative conversion can be reduced, and isomerization can be suppressed. On the other hand, consecutive isomerization can be deliberately promoted by evaporating excess methyl acrylate after completing cross metathesis and by adding a base or silane as chemical triggers.