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- Extern (122)
- Institut für Biochemie und Biologie (111)
- Institut für Geowissenschaften (67)
- Institut für Physik und Astronomie (66)
- Institut für Umweltwissenschaften und Geographie (45)
- Historisches Institut (41)
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- Hasso-Plattner-Institut für Digital Engineering GmbH (24)
Large quantities of the antibiotic florfenicol are used in animal farming and aquaculture, contaminating the ecosystem with antibiotic residues and promoting antimicrobial resistance, ultimately leading to untreatable multidrug-resistant pathogens. Florfenicol-resistant bacteria often activate export mechanisms that result in resistance to various structurally unrelated antibiotics. We devised novel strategies for the enzymatic inactivation of florfenicol in different media, such as saltwater or milk. Using a combinatorial approach and selection, we optimized a hydrolase (EstDL136) for florfenicol cleavage. Reaction kinetics were followed by time-resolved NMR spectroscopy. Importantly, the hydrolase remained active in different media, such as saltwater or cow milk. Various environmentally-friendly application strategies for florfenicol inactivation were developed using the optimized hydrolase. As a potential filter device for cost-effective treatment of waste milk or aquacultural wastewater, the hydrolase was immobilized on Ni-NTA agarose or silica as carrier materials. In two further application examples, the hydrolase was used as cell extract or encapsulated with a semi-permeable membrane. This facilitated, for example, florfenicol inactivation in whole milk, which can help to treat waste milk from medicated cows, to be fed to calves without the risk of inducing antibiotic resistance. Enzymatic inactivation of antibiotics, in general, enables therapeutic intervention without promoting antibiotic resistance.
The Covid-19 pandemic imposed new constraints on empirical research and forced researchers to transfer from traditional laboratory research to the online environment. This study tested the validity of a web-based episodic memory paradigm by comparing participants’ memory performance for trustworthy and untrustworthy facial stimuli in a supervised laboratory setting and an unsupervised web setting. Consistent with previous results, we observed enhanced episodic memory for untrustworthy compared to trustworthy faces. Most importantly, this memory bias was comparable in the online and the laboratory experiment, suggesting that web-based procedures are a promising tool for memory research.
Cognitive resources contribute to balance control. There is evidence that mental fatigue reduces cognitive resources and impairs balance performance, particularly in older adults and when balance tasks are complex, for example when trying to walk or stand while concurrently performing a secondary cognitive task.
We conducted a systematic literature search in PubMed (MEDLINE), Web of Science and Google Scholar to identify eligible studies and performed a random effects meta-analysis to quantify the effects of experimentally induced mental fatigue on balance performance in healthy adults. Subgroup analyses were computed for age (healthy young vs. healthy older adults) and balance task complexity (balance tasks with high complexity vs. balance tasks with low complexity) to examine the moderating effects of these factors on fatigue-mediated balance performance.
We identified 7 eligible studies with 9 study groups and 206 participants. Analysis revealed that performing a prolonged cognitive task had a small but significant effect (SMDwm = −0.38) on subsequent balance performance in healthy young and older adults. However, age- and task-related differences in balance responses to fatigue could not be confirmed statistically.
Overall, aggregation of the available literature indicates that mental fatigue generally reduces balance in healthy adults. However, interactions between cognitive resource reduction, aging and balance task complexity remain elusive.
Background and Objectives: Low back pain is a worldwide health problem. An early diagnosis is required to develop personalized treatment strategies. The Risk Stratification Index (RSI) was developed to serve the purpose. The aim of this pilot study is to cross-culturally translate the RSI to a French version (RSI-F) and evaluate the test-retest reliability of RSI-F using a French active population. Materials and Methods: The RSI was translated from German to French (RSI-F) based on the guidelines of cross-cultural adaptation of self-report measures. A total of 42 French recreational athletes (age 18–63 years) with non-specific low back pain were recruited and filled in the RSI-F twice. The test-retest reliability was examined using intraclass correlation coefficient (ICC1,2) and Pearson correlation coefficient. Results: Finally, 33 questionnaires were analyzed (14 males and 19 females, age 31 ± 10 years, 9.5 ± 3.2 h/week of training). The test-retest of RSI-F CPI and DISS were excellent (CPI: ICC1,2 = 0.989, p < 0.001; r = 0.989, p < 0.001; DISS: ICC1,2 = 0.991, p < 0.001; r = 0.991, p < 0.001), as well as Korff pain intensity (ICC1,2 = 0.995, p < 0.001; r = 0.995, p < 0.001) and disability (ICC1,2 = 0.998, p < 0.001; r = 0.998, p < 0.001). Conclusion: The RSI-F is linguistically accurate and reliable for use by a French-speaking active population with non-specific low back pain. The RSI-F is considered a tool to examine the evolution of psychosocial factors and therefore the risk of chronicity and the prognostic of pain. Further evaluations, such as internal, external validity, and responsiveness should be evaluated in a larger population.
Thousands of glacier lakes have been forming behind natural dams in high mountains following glacier retreat since the early 20th century. Some of these lakes abruptly released pulses of water and sediment with disastrous downstream consequences. Yet it remains unclear whether the reported rise of these glacier lake outburst floods (GLOFs) has been fueled by a warming atmosphere and enhanced meltwater production, or simply a growing research effort. Here we estimate trends and biases in GLOF reporting based on the largest global catalog of 1,997 dated glacier-related floods in six major mountain ranges from 1901 to 2017. We find that the positive trend in the number of reported GLOFs has decayed distinctly after a break in the 1970s, coinciding with independently detected trend changes in annual air temperatures and in the annual number of field-based glacier surveys (a proxy of scientific reporting). We observe that GLOF reports and glacier surveys decelerated, while temperature rise accelerated in the past five decades. Enhanced warming alone can thus hardly explain the annual number of reported GLOFs, suggesting that temperature-driven glacier lake formation, growth, and failure are weakly coupled, or that outbursts have been overlooked. Indeed, our analysis emphasizes a distinct geographic and temporal bias in GLOF reporting, and we project that between two to four out of five GLOFs on average might have gone unnoticed in the early to mid-20th century. We recommend that such biases should be considered, or better corrected for, when attributing the frequency of reported GLOFs to atmospheric warming.
How do different reset protocols affect ergodicity of a diffusion process in single-particle-tracking experiments? We here address the problem of resetting of an arbitrary stochastic anomalous-diffusion process (ADP) from the general mathematical points of view and assess ergodicity of such reset ADPs for an arbitrary resetting protocol. The process of stochastic resetting describes the events of the instantaneous restart of a particle’s motion via randomly distributed returns to a preset initial position (or a set of those). The waiting times of such resetting events obey the Poissonian, Gamma, or more generic distributions with specified conditions regarding the existence of moments. Within these general approaches, we derive general analytical results and support them by computer simulations for the behavior of the reset mean-squared displacement (MSD), the new reset increment-MSD (iMSD), and the mean reset time-averaged MSD (TAMSD). For parental nonreset ADPs with the MSD(t)∝ tμ we find a generic behavior and a switch of the short-time growth of the reset iMSD and mean reset TAMSDs from ∝ _μ for subdiffusive to ∝ _1 for superdiffusive reset ADPs. The critical condition for a reset ADP that recovers its ergodicity is found to be more general than that for the nonequilibrium stationary state, where obviously the iMSD and the mean TAMSD are equal. The consideration of the new statistical quantifier, the iMSD—as compared to the standard MSD—restores the ergodicity of an arbitrary reset ADP in all situations when the μth moment of the waiting-time distribution of resetting events is finite. Potential applications of these new resetting results are, inter alia, in the area of biophysical and soft-matter systems.
There is a large variety of goals instructors have for laboratory courses, with different courses focusing on different subsets of goals. An often implicit, but crucial, goal is to develop students’ attitudes, views, and expectations about experimental physics to align with practicing experimental physicists. The assessment of laboratory courses upon this one dimension of learning has been intensively studied in U.S. institutions using the Colorado Learning Attitudes about Science Survey for Experimental Physics (E-CLASS). However, there is no such an instrument available to use in Germany, and the influence of laboratory courses on students views about the nature of experimental physics is still unexplored at German-speaking institutions. Motivated by the lack of an assessment tool to investigate this goal in laboratory courses at German-speaking institutions, we present a translated version of the E-CLASS adapted to the context at German-speaking institutions. We call the German version of the E-CLASS, the GE-CLASS. We describe the translation process and the creation of an automated web-based system for instructors to assess their laboratory courses. We also present first results using GE-CLASS obtained at the University of Potsdam. A first comparison between E-CLASS and GE-CLASS results shows clear differences between University of Potsdam and U.S. students’ views and beliefs about experimental physics.
We introduce and study a Lévy walk (LW) model of particle spreading with a finite propagation speed combined with soft resets, stochastically occurring periods in which an harmonic external potential is switched on and forces the particle towards a specific position. Soft resets avoid instantaneous relocation of particles that in certain physical settings may be considered unphysical. Moreover, soft resets do not have a specific resetting point but lead the particle towards a resetting point by a restoring Hookean force. Depending on the exact choice for the LW waiting time density and the probability density of the periods when the harmonic potential is switched on, we demonstrate a rich emerging response behaviour including ballistic motion and superdiffusion. When the confinement periods of the soft-reset events are dominant, we observe a particle localisation with an associated non-equilibrium steady state. In this case the stationary particle probability density function turns out to acquire multimodal states. Our derivations are based on Markov chain ideas and LWs with multiple internal states, an approach that may be useful and flexible for the investigation of other generalised random walks with soft and hard resets. The spreading efficiency of soft-rest LWs is characterised by the first-passage time statistic.
Background:
Children’s spontaneous focusing on numerosity (SFON) is related to numerical skills. This study aimed to examine (1) the developmental trajectory of SFON and (2) the interrelations between SFON and early numerical skills at pre-school as well as their influence on arithmetical skills at school.
Method:
Overall, 1868 German pre-school children were repeatedly assessed until second grade. Nonverbal intelligence, visual attention, visuospatial working memory, SFON and numerical skills were assessed at age five (M = 63 months, Time 1) and age six (M = 72 months, Time 2), and arithmetic was assessed at second grade (M = 95 months, Time 3).
Results:
SFON increased significantly during pre-school. Path analyses revealed interrelations between SFON and several numerical skills, except number knowledge. Magnitude estimation and basic calculation skills (Time 1 and Time 2), and to a small degree number knowledge (Time 2), contributed directly to arithmetic in second grade. The connection between SFON and arithmetic was fully mediated by magnitude estimation and calculation skills at pre-school.
Conclusion:
Our results indicate that SFON first and foremost influences deeper understanding of numerical concepts at pre-school and—in contrast to previous findings –affects only indirectly children’s arithmetical development at school.
Studies have revealed mixed results on how antidepressant drugs affect lipid profiles of patients with major depression disorder (MDD). Even less is known about how patients respond to a switch of antidepressant medication with respect to their metabolic profile. For this, effects of a switch in antidepressants medication on lipid markers were studied in MDD patients. 15 participants (females = 86.67%; males = 13.33%; age: 49.45 ± 7.45 years) with MDD and a prescribed switch in their antidepressant medication were recruited at a psychosomatic rehabilitation clinic. Participants were characterized (with questionnaires and blood samples) at admission to the rehabilitation clinic (baseline, T0) and followed up with a blood sample two weeks (T1) later. HDL, LDL, total cholesterol, and triglycerides were determined (T0), and their change analyzed (Wilcoxon test) at follow up (T1). Decrements in HDL (p = 0.041), LDL (p < 0.001), and total cholesterol (p < 0.001) were observed two weeks after a switch in antidepressant medication. Triglycerides showed no difference (p = 0.699). Overall, LDL, HDL, and total cholesterol are affected by a change in antidepressant drugs in patients with MDD. These observations are of clinical relevance for medical practitioners in the planning and management of treatment strategies for MDD patients.
Scrollytellings are an innovative form of web content. Combining the benefits of books, images, movies, and video games, they are a tool to tell compelling stories and provide excellent learning opportunities. Due to their multi-modality, creating high-quality scrollytellings is not an easy task. Different professions, such as content designers, graphics designers, and developers, need to collaborate to get the best out of the possibilities the scrollytelling format provides. Collaboration unlocks great potential. However, content designers cannot create scrollytellings directly and always need to consult with developers to implement their vision. This can result in misunderstandings. Often, the resulting scrollytelling will not match the designer’s vision sufficiently, causing unnecessary iterations. Our project partner Typeshift specializes in the creation of individualized scrollytellings for their clients. Examined existing solutions for authoring interactive content are not optimally suited for creating highly customized scrollytellings while still being able to manipulate all their elements programmatically. Based on their experience and expertise, we developed an editor to author scrollytellings in the lively.next live-programming environment. In this environment, a graphical user interface for content design is combined with powerful possibilities for programming behavior with the morphic system. The editor allows content designers to take on large parts of the creation process of scrollytellings on their own, such as creating the visible elements, animating content, and fine-tuning the scrollytelling. Hence, developers can focus on interactive elements such as simulations and games. Together with Typeshift, we evaluated the tool by recreating an existing scrollytelling and identified possible future enhancements. Our editor streamlines the creation process of scrollytellings. Content designers and developers can now both work on the same scrollytelling. Due to the editor inside of the lively.next environment, they can both work with a set of tools familiar to them and their traits. Thus, we mitigate unnecessary iterations and misunderstandings by enabling content designers to realize large parts of their vision of a scrollytelling on their own. Developers can add advanced and individual behavior. Thus, developers and content designers benefit from a clearer distribution of tasks while keeping the benefits of collaboration.
Wheat alpha-amylase/trypsin inhibitors remain a subject of interest considering the latest findings showing their implication in wheat-related non-celiac sensitivity (NCWS). Understanding their functions in such a disorder is still unclear and for further study, the need for pure ATI molecules is one of the limiting problems. In this work, a simplified approach based on the successive fractionation of ATI extracts by reverse phase and ion exchange chromatography was developed. ATIs were first extracted from wheat flour using a combination of Tris buffer and chloroform/methanol methods. The separation of the extracts on a C18 column generated two main fractions of interest F1 and F2. The response surface methodology with the Doehlert design allowed optimizing the operating parameters of the strong anion exchange chromatography. Finally, the seven major wheat ATIs namely P01083, P17314, P16850, P01085, P16851, P16159, and P83207 were recovered with purity levels (according to the targeted LC-MS/MS analysis) of 98.2 ± 0.7; 98.1 ± 0.8; 97.9 ± 0.5; 95.1 ± 0.8; 98.3 ± 0.4; 96.9 ± 0.5, and 96.2 ± 0.4%, respectively. MALDI-TOF-MS analysis revealed single peaks in each of the pure fractions and the mass analysis yielded deviations of 0.4, 1.9, 0.1, 0.2, 0.2, 0.9, and 0.1% between the theoretical and the determined masses of P01083, P17314, P16850, P01085, P16851, P16159, and P83207, respectively. Overall, the study allowed establishing an efficient purification process of the most important wheat ATIs. This paves the way for further in-depth investigation of the ATIs to gain more knowledge related to their involvement in NCWS disease and to allow the absolute quantification in wheat samples.
Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.
Artificial light at night (ALAN) is altering the behaviour of nocturnal animals in a manifold of ways. Nocturnal invertebrates are particularly affected, due to their fatal attraction to ALAN. This selective pressure has the potential to reduce the strength of the flight-to-light response in insects, as shown recently in a moth species. Here we investigated light attraction of ground beetles (Coleoptera: Carabidae).We compared among animals (three genera) from a highly light polluted (HLP) grassland in the centre of Berlin and animals collected at a low-polluted area in a Dark Sky Reserve (DSR), captured using odour bait. In an arena setting tested at night time, HLP beetles (n = 75 across all genera) showed a reduced attraction towards ALAN. Tested during daytime, HLP beetles were less active in an open field test (measured as latency to start moving), compared to DSR (n = 143). However, we did not observe a reduced attraction towards ALAN within the species most common at both sides, Calathus fuscipes (HLP = 37, DSR = 118 individuals) indicating that not all species may be equally affected by ALAN. Reduced attraction to ALAN in urban beetles may either be a result of phenotypic selection in each generation removing HLP individuals that are attracted to light, or an indication for ongoing evolutionary differentiation among city and rural populations in their light response. Reduced attraction to light sources may directly enhance survival and reproductive success of urban individuals. However, decrease in mobility may negatively influence dispersal, reproduction and foraging success, highlighting the selective pressure that light pollution may have on fitness, by shaping and modifying the behaviour of insects.
We collect a network dataset of tenured economics faculty in Austria, Germany and Switzerland. We rank the 100 institutions included with a minimum violation ranking. This ranking is positively and significantly correlated with the Times Higher Education ranking of economics institutions. According to the network ranking, individuals on average go down about 23 ranks from their doctoral institution to their employing institution. While the share of females in our dataset is only 15%, we do not observe a significant gender hiring gap (a difference in rank changes between male and female faculty). We conduct a robustness check with the Handelsblatt and the Times Higher Education ranking. According to these rankings, individuals on average go down only about two ranks. We do not observe a significant gender hiring gap using these two rankings (although the dataset underlying this analysis is small and these estimates are likely to be noisy). Finally, we discuss the limitations of the network ranking in our context.
Fitness, risk taking, and spatial behavior covary with boldness in experimental vole populations
(2022)
Individuals of a population may vary along a pace-of-life syndrome from highly fecund, short-lived, bold, dispersive “fast” types at one end of the spectrum to less fecund, long-lived, shy, plastic “slow” types at the other end. Risk-taking behavior might mediate the underlying life history trade-off, but empirical evidence supporting this hypothesis is still ambiguous. Using experimentally created populations of common voles (Microtus arvalis)—a species with distinct seasonal life history trajectories—we aimed to test whether individual differences in boldness behavior covary with risk taking, space use, and fitness. We quantified risk taking, space use (via automated tracking), survival, and reproductive success (via genetic parentage analysis) in 8 to 14 experimental, mixed-sex populations of 113 common voles of known boldness type in large grassland enclosures over a significant part of their adult life span and two reproductive events. Populations were assorted to contain extreme boldness types (bold or shy) of both sexes. Bolder individuals took more risks than shyer ones, which did not affect survival. Bolder males but not females produced more offspring than shy conspecifics. Daily home range and core area sizes, based on 95% and 50% Kernel density estimates (20 ± 10 per individual, n = 54 individuals), were highly repeatable over time. Individual space use unfolded differently for sex-boldness type combinations over the course of the experiment. While day ranges decreased for shy females, they increased for bold females and all males. Space use trajectories may, hence, indicate differences in coping styles when confronted with a novel social and physical environment. Thus, interindividual differences in boldness predict risk taking under near-natural conditions and have consequences for fitness in males, which have a higher reproductive potential than females. Given extreme inter- and intra-annual fluctuations in population density in the study species and its short life span, density-dependent fluctuating selection operating differently on the sexes might maintain (co)variation in boldness, risk taking, and pace-of-life.
Botulinum neurotoxin (BoNT) is used for the treatment of a number of ailments. The activity of the toxin that is isolated from bacterial cultures is frequently tested in the mouse lethality assay. Apart from the ethical concerns inherent to this assay, species-specific differences in the affinity for different BoNT serotypes give rise to activity results that differ from the activity in humans. Thus, BoNT/B is more active in mice than in humans. The current study shows that the stimulus-dependent release of a luciferase from a differentiated human neuroblastoma–based reporter cell line (SIMA-hPOMC1-26-Gluc) was inhibited by clostridial and recombinant BoNT/A to the same extent, whereas both clostridial and recombinant BoNT/B inhibited the release to a lesser extent and only at much higher concentrations, reflecting the low activity of BoNT/B in humans. By contrast, the genetically modified BoNT/B-MY, which has increased affinity for human synaptotagmin, and the BoNT/B protein receptor inhibited luciferase release effectively and with an EC50 comparable to recombinant BoNT/A. This was due to an enhanced uptake into the reporter cells of BoNT/B-MY in comparison to the recombinant wild-type toxin. Thus, the SIMA-hPOMC1-26-Gluc cell assay is a versatile tool to determine the activity of different BoNT serotypes providing human-relevant dose-response data.
The protein fraction, important for coffee cup quality, is modified during post-harvest treatment prior to roasting. Proteins may interact with phenolic compounds, which constitute the major metabolites of coffee, where the processing affects these interactions. This allows the hypothesis that the proteins are denatured and modified via enzymatic and/or redox activation steps. The present study was initiated to encompass changes in the protein fraction. The investigations were limited to major storage protein of green coffee beans. Fourteen Coffea arabica samples from various processing methods and countries were used. Different extraction protocols were compared to maintain the status quo of the protein modification. The extracts contained about 4–8 µg of chlorogenic acid derivatives per mg of extracted protein. High-resolution chromatography with multiple reaction monitoring was used to detect lysine modifications in the coffee protein. Marker peptides were allocated for the storage protein of the coffee beans. Among these, the modified peptides K.FFLANGPQQGGK.E and R.LGGK.T of the α-chain and R.ITTVNSQK.I and K.VFDDEVK.Q of β-chain were detected. Results showed a significant increase (p < 0.05) of modified peptides from wet processed green beans as compared to the dry ones. The present study contributes to a better understanding of the influence of the different processing methods on protein quality and its role in the scope of coffee cup quality and aroma. View Full-Text
Background: In terms of physiological and biomechanical characteristics, over-pronation of the feet has been associated with distinct muscle recruitment patterns and ground reaction forces during running.
Objective: The aim of this study was to evaluate the effects of running on sand vs. stable ground on ground-reaction-forces (GRFs) and electromyographic (EMG) activity of lower limb muscles in individuals with over-pronated feet (OPF) compared with healthy controls.
Methods: Thirty-three OPF individuals and 33 controls ran at preferred speed and in randomized-order over level-ground and sand. A force-plate was embedded in an 18-m runway to collect GRFs. Muscle activities were recorded using an EMG-system. Data were adjusted for surface-related differences in running speed.
Results: Running on sand resulted in lower speed compared with stable ground running (p < 0.001; d = 0.83). Results demonstrated that running on sand produced higher tibialis anterior activity (p = 0.024; d = 0.28). Also, findings indicated larger loading rates (p = 0.004; d = 0.72) and greater vastus medialis (p < 0.001; d = 0.89) and rectus femoris (p = 0.001; d = 0.61) activities in OPF individuals. Controls but not OPF showed significantly lower gluteus-medius activity (p = 0.022; d = 0.63) when running on sand.
Conclusion: Running on sand resulted in lower running speed and higher tibialis anterior activity during the loading phase. This may indicate alterations in neuromuscular demands in the distal part of the lower limbs when running on sand. In OPF individuals, higher loading rates together with greater quadriceps activity may constitute a proximal compensatory mechanism for distal surface instability.
In den vergangenen Jahren hat der im anglo-amerikanischen Rechtsraum wurzelnde Amicus Curiae, wenn auch in unterschiedlicher Ausprägung, Eingang in die Verwaltungsgerichtsbarkeiten in Deutschland und Frankreich gefunden. Dabei erweist sich die französische Verwaltungsgerichtsordnung aus rechtsvergleichender Sicht als progressiv, da das Verfahrensinstrument hier – im Gegensatz zur deutschen Rechtslage – bereits positiv-rechtlich normiert ist. Diese Fortschrittlichkeit hat sich bisher jedoch nicht merklich auf die Drittinterventionspraxis niedergeschlagen, besitzen Amicus Curiae-Stellungnahmen doch in beiden Ländern und über alle verwaltungsgerichtlichen Instanzen hinweg noch immer Seltenheitswert.
Da mithin keine Generalisierungen zur dieser Rechtspraxis erlaubt sind, kann sich eine Analyse der möglichen funktionalen Rolle derartiger Amicus Curiae-Stellungnahmen nur auf theoretische Überlegungen stützen. Danach ist eine Informationsfunktion gegenüber dem Gericht in Bezug auf Tatsachen- und Rechtsfragen klar zu bejahen. Auch dürfte der Verfahrensmechanismus ein zusätzliches – wenngleich nicht demokratisches – Legitimationspotential für gerichtliche Entscheidungen besitzen: Indem dieser gesellschaftliche Teilhabe und damit gleichzeitig die Einbettung verwaltungsgerichtlicher Verfahren in den jeweiligen sozialen Kontext ermöglicht, kann er zur Steigerung der gesellschaftlichen Akzeptanz der zunehmend unter Rechtsfertigungsdruck geratenden Richtermacht beitragen.
Für projektorientierten Unterricht im Schulfach Wirtschaft, Arbeit, Technik ist die Auswahl an praxisorientierten Materialien übersichtlich. Umso erfreulicher ist es, dass Frau Sonja Halboth und Herr Tobias Hoffmann mit Schüler*innen ein Lichtmorsegerät im Rahmen projektorientierten Unterrichts angefertigt haben. Die vorliegende Arbeit gibt sowohl einen guten Überblick in die Möglichkeiten projektorientierten Unterrichts und dessen Bewertung als auch eine Menge praktischer Tipps & Materialien, um projektorientierten Unterricht durchzuführen.
Dieses Papier thematisiert die völkerstrafrechtliche Einordnung rein störender, also nicht zerstörender Cyberoperationen. Nach der erforderlichen Begriffsklärung werden die einzelnen Fragen der Anwendbarkeit des Völkerstrafrechts erörtert und geprüft, welche Tatbestände durch solche Aktionen verwirklicht werden können.
This paper examines the function that cross-cultural competence (3C) has for NATO in a military context while focusing on two member states and their armed forces: the United States and Germany. Three dimensions were established to analyze 3C internally and externally: dimension A, dealing with 3C within the military organization; dimension B, focusing on 3C in a coalition environment/multicultural NATO contingent, for example while on a mission/training exercise abroad; and dimension C, covering 3C and NATO missions abroad with regard to interaction with the local population.
When developing the research design, the cultural studies-based theory of hegemony constructed by Antonio Gramsci was applied to a comprehensive document analysis of 3C coursework and regulations as well as official documents in order to establish a typification for cross-cultural competence.
As the result, 3C could be categorized as Type I – Ethical 3C, Type II – Hegemonic 3C, and Type III – Dominant 3C. Attributes were assigned according to each type. To validate the established typification, qualitative surveys were conducted with NATO (ACT), the U.S. Armed Forces (USCENTCOM), and the German Armed Forces (BMVg). These interviews validated the typification and revealed a varied approach to 3C in the established dimensions. It became evident that dimensions A and B indicated a prevalence of Type III, which greatly impacts the work atmosphere and effectiveness for NATO (ACT). In contrast, dimension C revealed the use of postcolonial mechanisms by NATO forces, such as applying one’s value systems to other cultures and having the appearance of an occupying force when 3C is not applied (Type I-II). In general, the function of each 3C type in the various dimensions could be determined.
In addition, a comparative study of the document analysis and the qualitative surveys resulted in a canon for culture-general skills. Regarding the determined lack of coherence in 3C correlating with a demonstrably negative impact on effectiveness and efficiency as well as interoperability, a NATO standard in the form of a standardization agreement (STANAG) was suggested based on the aforementioned findings, with a focus on: empathy, cross-cultural awareness, communication skills (including active listening), flexibility and adaptability, and interest. Moreover, tolerance of ambiguity and teachability, patience, observation skills, and perspective-taking could be considered significant. Suspending judgment and respect are also relevant skills here.
At the same time, the document analysis also revealed a lack of coherency and consistency in 3C education and interorganizational alignment. In particular, the documents examined for the U.S. Forces indicated divergent approaches. Furthermore, the interview analysis disclosed a large discrepancy in part between doctrine and actual implementation with regard to the NATO Forces.
Die vorliegende Bachelorarbeit beschäftigt sich mit dem Einfluss von Digitalisierung auf die öffentliche Verwaltung in Deutschland. Den konkreten Untersuchungsschwerpunkt bilden organisationale Routinen. Die Arbeit gibt einen konzeptionellen Überblick über die Begriffe Digitalisierung und organisationale Routinen und leitet daraus Arbeitsdefinitionen ab. Der theoretisch dargelegte Zusammenhang zwischen den beiden Phänomenen wird im Rahmen von drei teilstrukturierten Interviews mit Mitarbeitenden aus unterschiedlichen öffentlichen Verwaltungen untersucht. Die herausgearbeiteten Definitionen wurden den Interviewten vorgestellt und durch ein Repertoire an Fragen die Wahrnehmung des Digitalisierungsstandes i.V.m. Routinen abgefragt.
Die Ergebnisse zeigen, dass digitaler Wandel und Routinen in jedem der interviewten Fachbereiche zumindest unterbewusst wahrgenommen wird. Digitalisierung und organisationale Routinen stehen in Wechselwirkung zueinander, da die wiederholte routinierte Ausführung von Tätigkeiten die Implementierung von Digitalisierung begünstigt. Darüber hinaus führt digitaler Wandel zur Veränderung von Routinen, welche mit einem anfänglichen Mehraufwand verbunden ist. Störungen bei der Implementierung von Digitalisierung bringen eine Starrheit von Routinen mit sich u.A. durch eine fehlende Bereitschaft der Mitarbeitenden. Die grundlegend bestehende Wechselwirkung ist ausschlaggebend für die Schnittstellen zwischen Digitalisierung und organisationalen Routinen in der öffentlichen Verwaltung.
-Karin Reich, Elena Roussanova: Der 2019 wiederaufgefundene Brief von Gauß an Humboldt vom 17. August 1832 im Umfeld der Erforschung des Magnetismus und des Erdmagnetismus
-Dagmar Hülsenberg: Anwendung naturwissenschaftlicher und kameralistischer Erkenntnisse auf die Verarbeitung von Rohstoffen durch den jungen Alexander von Humboldt
-Peter Korneffel: Alexander von Humboldt postfrisch: Die Rezeption des deutschen Naturforschers in der weltweiten Philatelie
-Jie-Oun Lee: Erzählstrategien eines transdisziplinären Naturforschers
-Eberhard Schulz-Lüpertz: Alexander von Humboldt und Ulrich Jasper Seetzen – Auf den Spuren eines Helgoland-Briefs
-Ulrich Stottmeister: Der Mineraloge August Schmidt und die Entdeckung der Ural-Diamanten 1829 Teil II: Schmidts wissenschaftlicher Diamanten-Beweis und sein weiteres Schicksal im Ural
-Petra Werner: Ernste Kunst kann nicht gedeihen ohne Gunst. Mäzene und Unterstützer des Malers Albert Berg (1825 – 1884)
-Frank Holl: Hinweis zum Beitrag von Irene Prüfer Leske in HiN, Bd. 22, Nr. 43 (2021)
Der vorliegende Abschlussbericht umfasst die Ergebnisse der wissenschaftlichen Evaluation der Werkstatt „Schule leiten“. Bei dieser Werkstatt handelt es sich um ein 18-monatiges Fortbildungsangebot für Schulleitungen, das durch die Deutsche Schulakademie konzipiert und in Kooperation mit dem saarländischen Kultusministerium für Bildung und Kultur sowie dem saarländischen Landesinstitut für Pädagogik und Medien durchgeführt wurde. Im Zeitraum 2016–2020 absolvierten jeweils zwei Personen des Schulleitungsteams allgemeinbildender Schulen erstmalig in insgesamt drei Durchgängen verschiedene Angebote der Werkstatt. Weiterhin erhielten die Teilnehmenden die Aufgaben, im Zuge ihres Fortbildungsbesuches ein individuelles Schulentwicklungsprojekt zu planen, zu entwickeln und unter Anleitung der Werkstatt in der Schule zu implementieren. Zur Überprüfung der wahrgenommenen Qualität sowie der Wirksamkeit des Fortbildungsangebotes wurde die Universität Potsdam, Arbeitsbereich Prof. Dr. Dirk Richter, beauftragt. Der vorliegende Bericht präsentiert die Evaluationsergebnisse der Durchgänge 2 und 3.
Im Zentrum der Evaluation stehen die folgenden Forschungsfragen: (1) Wie beurteilen die Teilnehmenden die Qualität der Werkstatt „Schule leiten“? (2) Inwiefern hat die Werkstatt „Schule leiten“ dazu beigetragen, die Leitungskompetenzen (u.a. Einstellungen und Führungshandeln) der Teilnehmenden zu stärken? sowie (3) Wie haben sich schulische Strukturen und Prozesse zur Förderung von Schulentwicklung in den teilnehmenden Schulen durch die Werkstatt „Schule leiten“ verändert? Zur Beantwortung der Fragestellungen wurden eine Reihe schriftlicher Befragungen mit den teilnehmenden Schulleitungen sowie den Lehrkräften der teilnehmenden Schulen durchgeführt. Diese Befragungen erfolgten sowohl begleitend zum Fortbildungsprogramm (nach Absolvieren der einzelnen Angebote) sowie in einem Prä-Post-Follow-Up-Design. Weiterhin wurden im Rahmen einer qualitativen Begleitstudie verschiedene Personen (Schulleitung, Mitglieder des Schulleitungsteams, Lehrkräfte) von insgesamt fünf Schulen über drei Zeitpunkte dazu befragt, wie die Planung, Entwicklung und Implementation der Schulentwicklungsprojekte erfolgten.
Die Befunde der Evaluation deuten insgesamt darauf hin, dass die Qualität der Werkstatt „Schule leiten“ als Gesamtprogramm sowie die einzelnen Angebote der Werkstatt sehr positiv bewertet werden. Dabei nehmen die Teilnehmenden von Durchgang 2 die Werkstatt in einer Reihe von Merkmalen positiver wahr als die Teilnehmenden von Durchgang 3. Weiterhin deuten die Ergebnisse darauf hin, dass sich bestimmte Facetten des Führungshandelns der Teilnehmenden im zeitlichen Verlauf positiv verändert haben. Hierfür existieren Hinweise sowohl aus Perspektive der Teilnehmenden selbst als auch aus Perspektive der Lehrkräfte ihrer Schulen. Motivationale Merkmale der Teilnehmenden sowie Aspekte des Führungshandelns, die sich auf Tätigkeiten zur Unterstützung der innerschulischen Kooperation beziehen, bleiben aus Perspektive der Teilnehmenden hingegen weitestgehend konstant. Hinsichtlich der Veränderungen schulischer Strukturen zur Schulentwicklung deuten die Ergebnisse auf eine positive Entwicklung der wahrgenommenen Offenheit gegenüber Kooperation im Kollegium aus Perspektive der Lehrkräfte hin. Die Befunde der qualitativen Begleitstudie liefern weitere Informationen über die wahrgenommene Qualität der Werkstatt sowie über Veränderungen aufseiten der Teilnehmenden und der schulischen Strukturen.
In March 2021, the IMAGINES Project – an international and interdisciplinary research network for the modern reception of antiquity in the visual and performing arts – held their seventh conference online. The event focused on PLAYFUL CLASSICS, and was hosted from Göttingen University by the organizers Juliette Harrisson, Antje Kuhle and Martin Lindner.
The keynote by Dunstan Lowe on „The Danger of Seriousness: Play and the Future of Classics“ outlined the potential of researching classical reception as a creative process. The following sections brought this to life with in-depth treatments of the underlying mechanics of constructing and deconstructing, playful learning, the „Faces of Antiquity“, forms of interaction and national/nationalistic traditions. The programme combined scholarly contributions with presentations and workshops by various artists and open discussion elements.
The shift to an online format allowed the participation of an unusually international audience, while the interactive elements – including a thematic game as a continuous side event – especially encouraged a large number of students to participate actively. Therefore, this conference report will not just summarize the content of the event, but also provide a student perspective on attending a conference on classical reception – a research area which is mostly neglected in the teaching curriculum.
Demagogen dichten
(2022)
Manipulative rhetoric is a common issue in ancient sources. As the issue of political populism and rhetoric still attracts a high degree of interest among a wide range of people, the author, a singer-songwriter, attempts to ‘revive’ these ancient sources and to adapt them into a lyrical/musical format for modern audiences, in order to test different strategies of manipulation and gauge the reactions of modern audiences. The following article describes the process of adapting and performing two of these experiments, as well as the results and feedback from audiences. The ancient case studies chosen for this are Thucydides’ description of how Alcibiades lead the Athenians into a fatal expedition to Sicily, and Xenophon’s blames of two public orators for executing Athenian generals after the battle of Arginusae through their manipulative speeches.
Given the immense ethnic and cultural diversity as well as the vast geographical dimensions of the Roman Empire, the teaching of Roman antiquity comprises an enormous potential to deal with the increasing heterogeneity in German-speaking classrooms. This article aims to show how the majority of contemporaneous Latin textbooks, however, fail to use this potential by being limited to mono-perspective and Eurocentric approaches to the ancient world.
In spite of didactical claims to foster students’ intercultural competence, most of the textbooks depict the city of Rome as an ethnically and culturally homogeneous sphere. At the same time, they present the Roman Empire nearly exclusively from the perspective of representatives of Italian-born, powerful upper-class families firmly connected to ‘Roman’ culture. In doing so, the Latin textbooks falsify the ancient historical realities and deprive students of the perspectives of figures like provincials or slaves. Furthermore, the textbooks’ narrative scope clearly focusses on Rome and Greece, still paying noticeable attention to West-European provinces, with the African and Asian ones being remarkably excluded. Only few exceptions among the textbooks apply alternative approaches which allow students to engage with the Roman Empire’s intercultural dynamics in a more differentiated and multi-perspective way.
Within Persona 5’s modern Tokyo setting, imagined worlds are created that represent the cognitive processes of various characters. These ‘palaces’ allow the player to explore locations far removed from the game’s real-world, contemporary backdrop. One episode creates an ancient Egyptian world. This article examines how this world has been produced and the different transmedial tropes and other influences that its developers have drawn upon. Many references are recognisable to a broad audience (pyramids, gods, hieroglyphs), while others reflect Japanese pop-cultural trends (in various manga and anime), including the mention of an obscure Egyptian god, Medjed. The intentionally fictitious nature of these ‘palaces’ means that the Egypt that appears in this game is not bound by the need to replicate an ‘accurate’ landscape. Instead, the developers were free to design a gamescape that combines multiple and diverse receptions of ancient Egypt.
Spring Issue
(2022)
Models are useful tools for understanding and predicting ecological patterns and processes. Under ongoing climate and biodiversity change, they can greatly facilitate decision-making in conservation and restoration and help designing adequate management strategies for an uncertain future. Here, we review the use of spatially explicit models for decision support and to identify key gaps in current modelling in conservation and restoration. Of 650 reviewed publications, 217 publications had a clear management application and were included in our quantitative analyses. Overall, modelling studies were biased towards static models (79%), towards the species and population level (80%) and towards conservation (rather than restoration) applications (71%). Correlative niche models were the most widely used model type. Dynamic models as well as the gene-to-individual level and the community-to-ecosystem level were underrepresented, and explicit cost optimisation approaches were only used in 10% of the studies. We present a new model typology for selecting models for animal conservation and restoration, characterising model types according to organisational levels, biological processes of interest and desired management applications. This typology will help to more closely link models to management goals. Additionally, future efforts need to overcome important challenges related to data integration, model integration and decision-making. We conclude with five key recommendations, suggesting that wider usage of spatially explicit models for decision support can be achieved by 1) developing a toolbox with multiple, easier-to-use methods, 2) improving calibration and validation of dynamic modelling approaches and 3) developing best-practise guidelines for applying these models. Further, more robust decision-making can be achieved by 4) combining multiple modelling approaches to assess uncertainty, and 5) placing models at the core of adaptive management. These efforts must be accompanied by long-term funding for modelling and monitoring, and improved communication between research and practise to ensure optimal conservation and restoration outcomes.
Das vorliegende Material soll dazu dienen, Schülern, die sich in unserem Gesundheitssystem kaum Sorgen um ihre Versorgung im Krankheitsfall machen müssen, im Lateinunterricht eine Kultur nahe zu bringen, in der die Arztpraxis ein paar Straßen weiter keine Selbstverständlichkeit war. Angesichts der geringen Zahl an Lektüreheften, die sich mit dem Thema "Medizin in der Antike" befassen, wird letzteres in dieser Arbeit für den Einsatz in der Schule neu aufgearbeitet. Das Konzept des Materials sieht vor, dass es unverändert im Rahmen einer Unterrichtssequenz eingesetzt werden kann. Doch auch die unabhängige Verwendung einzelner Kapitel ist problemlos möglich.
Language developers who design domain-specific languages or new language features need a way to make fast changes to language definitions. Those fast changes require immediate feedback. Also, it should be possible to parse the developed languages quickly to handle extensive sets of code.
Parsing expression grammars provides an easy to understand method for language definitions. Packrat parsing is a method to parse grammars of this kind, but this method is unable to handle left-recursion properly. Existing solutions either partially rewrite left-recursive rules and partly forbid them, or use complex extensions to packrat parsing that are hard to understand and cost-intensive. We investigated methods to make parsing as fast as possible, using easy to follow algorithms while not losing the ability to make fast changes to grammars.
We focused our efforts on two approaches.
One is to start from an existing technique for limited left-recursion rewriting and enhance it to work for general left-recursive grammars. The second approach is to design a grammar compilation process to find left-recursion before parsing, and in this way, reduce computational costs wherever possible and generate ready to use parser classes.
Rewriting parsing expression grammars is a task that, if done in a general way, unveils a large number of cases such that any rewriting algorithm surpasses the complexity of other left-recursive parsing algorithms. Lookahead operators introduce this complexity. However, most languages have only little portions that are left-recursive and in virtually all cases, have no indirect or hidden left-recursion. This means that the distinction of left-recursive parts of grammars from components that are non-left-recursive holds great improvement potential for existing parsers.
In this report, we list all the required steps for grammar rewriting to handle left-recursion, including grammar analysis, grammar rewriting itself, and syntax tree restructuring. Also, we describe the implementation of a parsing expression grammar framework in Squeak/Smalltalk and the possible interactions with the already existing parser Ohm/S. We quantitatively benchmarked this framework directing our focus on parsing time and the ability to use it in a live programming context. Compared with Ohm, we achieved massive parsing time improvements while preserving the ability to use our parser it as a live programming tool.
The work is essential because, for one, we outlined the difficulties and complexity that come with grammar rewriting. Also, we removed the existing limitations that came with left-recursion by eliminating them before parsing.
Vom Bolschoi nach Sanssouci
(2022)