Epigenetic contribution to obesity
- Obesity is a worldwide epidemic and contributes to global morbidity and mortality mediated via the development of nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), cardiovascular (CVD) and other diseases. It is a consequence of an elevated caloric intake, a sedentary lifestyle and a genetic as well as an epigenetic predisposition. This review summarizes changes in DNA methylation and microRNAs identified in blood cells and different tissues in obese human and rodent models. It includes information on epigenetic alterations which occur in response to fat-enriched diets, exercise and metabolic surgery and discusses the potential of interventions to reverse epigenetic modifications.
| Author details: | Meriem OuniORCiD, Annette SchürmannORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1007/s00335-020-09835-3 |
| ISSN: | 0938-8990 |
| ISSN: | 1432-1777 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/32279091 |
| Title of parent work (English): | Mammalian genome |
| Publisher: | Springer |
| Place of publishing: | New York, NY ; Berlin ; Heidelberg [u.a.] |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2020/04/11 |
| Publication year: | 2020 |
| Release date: | 2023/04/21 |
| Volume: | 31 |
| Issue: | 5-6 |
| Number of pages: | 12 |
| First page: | 134 |
| Last Page: | 145 |
| Funding institution: | BMBFFederal Ministry of Education & Research (BMBF) [82DZD00302] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 50 Naturwissenschaften |
| Peer review: | Referiert |
| Publishing method: | Open Access / Hybrid Open-Access |
| License (German): |  CC-BY - Namensnennung 4.0 International |
