- We present time-dependent density matrix renormalization group simulations (t-DMRG) at finite temperatures. It is demonstrated how a combination of finite-temperature t-DMRG and time-series prediction allows for an easy and very accurate calculation of spectral functions in one-dimensional quantum systems, irrespective of their statistics for arbitrary temperatures. This is illustrated with spin structure factors of XX and XXX spin-1/2 chains. For the XX model we can compare against an exact solution, and for the XXX model (Heisenberg antiferromagnet) against a Bethe ansatz solution and quantum Monte Carlo data.