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Photocontrol of Coiled-Coil Proteins in Living Cells
- Light switching of the activity of a coiled-coil protein, the AP-1 transcription factor, in living cells was made possible by the introduction of a designed azobenzene-cross-linked dominant negative peptide, XAFosW (red and yellow in the picture). In the dark, XAFosW showed decreased helical content and decreased affinity for target Jun proteins (green); irradiation at 365 nm enhanced helicity and target affinity.
Author details: | Fuzhong Z. Zhang, Katharina A. Timm, Katja Maren ArndtORCiDGND, G. Andrew Woolley |
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URL: | http://www3.interscience.wiley.com/cgi-bin/jhome/26737/ |
DOI: | https://doi.org/10.1002/anie.201000909 |
ISSN: | 1433-7851 |
Publication type: | Article |
Language: | English |
Year of first publication: | 2010 |
Publication year: | 2010 |
Release date: | 2017/03/25 |
Source: | Angewandte Chemie : international edition. - ISSN 1433-7851. - 49 (2010), 23, S. 3943 - 3946 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
Peer review: | Referiert |