Comparison of metabolite profiles in U87 glioma cells and mesenchymal stem cells
- Gas chromatography-mass spectrometry (GC-MS) profiles were generated from U87 glioma cells and human mesenchymal stem cells (hMSC). 37 metabolites representing glycolysis intermediates, TCA cycle metabolites, amino acids and lipids were selected for a detailed analysis. The concentrations of these. metabolites were compared and Pearson correlation coefficients were used to calculate the relationship between pairs of metabolites. Metabolite profiles and correlation patterns differ significantly between the two cell lines. These profiles can be considered as a signature of the underlying biochemical system and provide snap-shots of the metabolism in mesenchymal stem cells and tumor cells.
| Verfasserangaben: | Kathrin Juerchott, Ke-Tai Guo, Gareth Catchpole, Kristen Feher, Lothar WillmitzerORCiDGND, Christian Schichor, Joachim SelbigGND |
|---|---|
| DOI: | https://doi.org/10.1016/j.biosystems.2011.05.005 |
| ISSN: | 0303-2647 |
| Titel des übergeordneten Werks (Englisch): | Biosystems : journal of biological and information processing sciences |
| Verlag: | Elsevier |
| Verlagsort: | Oxford |
| Publikationstyp: | Wissenschaftlicher Artikel |
| Sprache: | Englisch |
| Jahr der Erstveröffentlichung: | 2011 |
| Erscheinungsjahr: | 2011 |
| Datum der Freischaltung: | 26.03.2017 |
| Freies Schlagwort / Tag: | Correlation networks; Human mesenchymal stem cells; Metabolite profiles; U87 glioma cells |
| Band: | 105 |
| Ausgabe: | 2 |
| Seitenanzahl: | 10 |
| Erste Seite: | 130 |
| Letzte Seite: | 139 |
| Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer Review: | Referiert |
