Evolution of centrosomes and the nuclear lamina: Amoebozoan assets
- The current eukaryotic tree of life groups most eukaryotes into one of five supergroups, the Opisthokonta, Amoebozoa, Archaeplastida, Excavata and SAR (Stramenopile, Alveolata, Rhizaria). Molecular and comparative morphological analyses revealed that the last eukaryotic common ancestor (LECA) already contained a rather sophisticated equipment of organelles including a mitochondrion, an endomembrane system, a nucleus with a lamina, a microtubule-organizing center (MTOC), and a flagellar apparatus. Recent studies of MTOCs, basal bodies/centrioles, and nuclear envelope organization of organisms in different supergroups have clarified our picture of how the nucleus and MTOCs co-evolved from LECA to extant eukaryotes. In this review we summarize these findings with special emphasis on valuable contributions of research on a lamin-like protein, nuclear envelope proteins, and the MTOC in the amoebozoan model organism Dictyostelium discoideum. (C) 2015 Elsevier GmbH. All rights reserved.
| Author details: | Ralph GräfORCiDGND, Petros BatsiosORCiDGND, Irene Meyer |
|---|---|
| DOI: | https://doi.org/10.1016/j.ejcb.2015.04.004 |
| ISSN: | 0171-9335 |
| ISSN: | 1618-1298 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/25952183 |
| Title of parent work (English): | European journal of cell biology |
| Publisher: | Elsevier |
| Place of publishing: | Jena |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2015 |
| Publication year: | 2015 |
| Release date: | 2017/03/27 |
| Tag: | Basal body; Centriole; Centrosome; LEM-domain; LINC complex; Lamin; Nuclear envelope; Nuclear lamina; Sun1 |
| Volume: | 94 |
| Issue: | 6 |
| Number of pages: | 8 |
| First page: | 249 |
| Last Page: | 256 |
| Funding institution: | Deutsche Forschungsgemeinschaft [GR1642/4-3] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer review: | Referiert |
