Nutritive manganese and zinc overdosing in aging c. elegans result in a metallothionein-mediated alteration in metal homeostasis

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Manganese (Mn) and zinc (Zn) are not only essential trace elements, but also potential exogenous risk factors for various diseases. Since the disturbed homeostasis of single metals can result in detrimental health effects, concerns have emerged regarding the consequences of excessive exposures to multiple metals, either via nutritional supplementation or parenteral nutrition. This study focuses on Mn-Zn-interactions in the nematode Caenorhabditis elegans (C. elegans) model, taking into account aspects related to aging and age-dependent neurodegeneration.

Metadaten
Author details:	Jessica Baesler ORCiD GND, Vivien Michaelis GND, Michael Stiboller ORCiD, Hajo Haase ORCiD GND, Michael Aschner ORCiD GND, Tanja Schwerdtle ORCiD GND, Stephen R. Sturzenbaum, Julia Bornhorst ORCiD GND
URN:	urn:nbn:de:kobv:517-opus4-514995
DOI:	https://doi.org/10.25932/publishup-51499
ISSN:	1866-8372
Title of parent work (German):	Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
Publication series (Volume number):	Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (1364)
Publication type:	Postprint
Language:	English
Date of first publication:	2021/03/09
Publication year:	2021
Publishing institution:	Universität Potsdam
Release date:	2024/03/22
Tag:	C. elegans; aging; homeostasis; manganese; zinc
Issue:	8
Article number:	2001176
Number of pages:	13
Source:	Mol. Nutr. Food Res. 2021, 65, 2001176. https://doi.org/10.1002/mnfr.202001176
Organizational units:	Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft
DDC classification:	5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
	6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Peer review:	Referiert
Publishing method:	Open Access / Green Open-Access
License (German):	CC-BY - Namensnennung 4.0 International
External remark:	Bibliographieeintrag der Originalveröffentlichung/Quelle