Tsegaye Deyou, Makungu Marco, Matthias Heydenreich, Fangfang Pan, Amra Gruhonjic, Paul A. Fitzpatrick, Andreas Koch, Solomon Derese, Jerry Pelletier, Kari Rissanen, Abiy Yenesew, Mate Erdelyi
- A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A-D (2-5), along with nine known compounds (6-14), were isolated from the CH2Cl2/CH3OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8 mu M, respectively.
Metadaten| Author details: | Tsegaye Deyou, Makungu Marco, Matthias HeydenreichORCiD, Fangfang Pan, Amra Gruhonjic, Paul A. Fitzpatrick, Andreas KochORCiDGND, Solomon DereseORCiD, Jerry Pelletier, Kari RissanenORCiD, Abiy YenesewORCiD, Mate ErdelyiORCiD |
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| DOI: | https://doi.org/10.1021/acs.jnatprod.7b00255 |
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| ISSN: | 0163-3864 |
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| ISSN: | 1520-6025 |
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| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/28665590 |
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| Title of parent work (English): | Journal of natural products |
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| Publisher: | American Chemical Society |
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| Place of publishing: | Washington |
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| Publication type: | Article |
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| Language: | English |
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| Date of first publication: | 2017/07/28 |
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| Publication year: | 2017 |
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| Release date: | 2022/04/14 |
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| Volume: | 80 |
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| Number of pages: | 7 |
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| First page: | 2060 |
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| Last Page: | 2066 |
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| Funding institution: | German Academic Exchange Service (DAAD) through the Natural Products Research Network for Eastern and Central Africa (NAPRECA); Swedish Research Council [201605857]; Academy of Finland [263256, 265328, 292746]; University of Jyvaskyla; Royal Society of Arts and Sciences in Goteborg |
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| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
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| DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
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| Peer review: | Referiert |
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| Publishing method: | Open Access / Bronze Open-Access |
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