The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis
- Endocardial cells are cardiac endothelial cells that line the interior of the heart tube. Historically, their contribution to cardiac development has mainly been considered from a morphological perspective. However, recent studies have begun to define novel instructive roles of the endocardium, as a sensor and signal transducer of biophysical forces induced by blood flow, and as an angiocrine signalling centre that is involved in myocardial cellular morphogenesis, regeneration and reprogramming. In this Review, we discuss how the endocardium develops, how endocardial-myocardial interactions influence the developing embryonic heart, and how the dysregulation of blood flowresponsive endocardial signalling can result in pathophysiological changes.
| Author details: | Timm Haack, Salim Abdelilah-SeyfriedORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1242/dev.131425 |
| ISSN: | 0950-1991 |
| ISSN: | 1477-9129 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/26839341 |
| Title of parent work (English): | Development : Company of Biologists |
| Publisher: | Company of Biologists Limited |
| Place of publishing: | Cambridge |
| Publication type: | Review |
| Language: | English |
| Year of first publication: | 2016 |
| Publication year: | 2016 |
| Release date: | 2020/03/22 |
| Tag: | Bmp; Cardiac development; Endocardium; Hemodynamics; Kruppel-like factor 2; Mechanotransduction; Mouse; Vegf; Zebrafish |
| Volume: | 143 |
| Number of pages: | 14 |
| First page: | 373 |
| Last Page: | 386 |
| Funding institution: | cluster REBIRTH; Deutsche Forschungsgemeinschaft (DFG) [SE2016/7-2, SE2016/10-1]; [SFB958] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer review: | Referiert |
