Reversible 2D networks of oligo(epsilon-caprolactone) at the air-water interface
- Hydroxyl terminated oligo(epsilon-caprolactone) (OCL) monolayers were reversibly cross-linked forming two dimensional networks (2D) at the air-water interface. The equilibrium reaction with glyoxal as the cross-linker is pH-sensitive. Pronounced contraction in the area of the prepared 2DOCL films in dependence of surface pressure and time revealed the process of the reaction. Cross-linking inhibited crystallization and retarded enzymatic degradation of the OCLfilm. Altering the subphase pH led to a cleavage of the covalent acetal cross-links. The reversibility of the covalent acetal cross-links was proved by observing an identical isotherm as non-cross-linked sample. Besides as model systems, these customizable reversible OCL2D networks are intended for use as pHresponsive drug delivery systems or functionalized cell culture substrates.
Author details: | Shivam Saretia, Rainhard Gabriel MachatschekORCiDGND, Burkhard SchulzORCiDGND, Andreas LendleinORCiDGND |
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DOI: | https://doi.org/10.1088/1748-605X/ab0cef |
ISSN: | 1748-6041 |
ISSN: | 1748-605X |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30836335 |
Title of parent work (English): | Biomedical Materials |
Publisher: | IOP Publ. Ltd. |
Place of publishing: | Bristol |
Publication type: | Article |
Language: | English |
Date of first publication: | 2019/04/03 |
Publication year: | 2019 |
Release date: | 2021/06/21 |
Tag: | cross-linking; crystallization; langmuir monolayer; poly(epsilon-caprolactone); two dimensional network |
Volume: | 14 |
Issue: | 3 |
Number of pages: | 10 |
Funding institution: | Helmholtz Graduate School for Macromolecular Bioscience; Helmholtz AssociationHelmholtz Association |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer review: | Referiert |
Publishing method: | Open Access / Hybrid Open-Access |
License (English): | Creative Commons - Namensnennung 3.0 Unported |