The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis
- Endocardial cells are cardiac endothelial cells that line the interior of the heart tube. Historically, their contribution to cardiac development has mainly been considered from a morphological perspective. However, recent studies have begun to define novel instructive roles of the endocardium, as a sensor and signal transducer of biophysical forces induced by blood flow, and as an angiocrine signalling centre that is involved in myocardial cellular morphogenesis, regeneration and reprogramming. In this Review, we discuss how the endocardium develops, how endocardial-myocardial interactions influence the developing embryonic heart, and how the dysregulation of blood flowresponsive endocardial signalling can result in pathophysiological changes.
| Verfasserangaben: | Timm Haack, Salim Abdelilah-SeyfriedORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1242/dev.131425 |
| ISSN: | 0950-1991 |
| ISSN: | 1477-9129 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/26839341 |
| Titel des übergeordneten Werks (Englisch): | Development : Company of Biologists |
| Verlag: | Company of Biologists Limited |
| Verlagsort: | Cambridge |
| Publikationstyp: | Rezension |
| Sprache: | Englisch |
| Jahr der Erstveröffentlichung: | 2016 |
| Erscheinungsjahr: | 2016 |
| Datum der Freischaltung: | 22.03.2020 |
| Freies Schlagwort / Tag: | Bmp; Cardiac development; Endocardium; Hemodynamics; Kruppel-like factor 2; Mechanotransduction; Mouse; Vegf; Zebrafish |
| Band: | 143 |
| Seitenanzahl: | 14 |
| Erste Seite: | 373 |
| Letzte Seite: | 386 |
| Fördernde Institution: | cluster REBIRTH; Deutsche Forschungsgemeinschaft (DFG) [SE2016/7-2, SE2016/10-1]; [SFB958] |
| Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer Review: | Referiert |
