Reaction of pharmacological active tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfanylacetate with ZnCl2 or NiCl2
- The reaction of pharmacological active protic ionic liquid tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfanylacetate H + N(CH 2 CH 2 OH) 3 ∙ ( - OOCCH 2 SC 6 H 4 Cl-4) (1) with zinc or nickel chloride in a ratio of 2:1 affords stable at room temperature powder-like adducts [H + N(CH 2 CH 2 OH) 3 ] 2 ∙ [M(OOCCH 2 SC 6 H 4 Cl-4) 2 Cl 2 ] 2- , M = Zn (2), Ni (3). By recrystallization from aqueous alcohol compound 2 unexpectedly gives Zn(OOCCH 2 SC 6 H 4 Cl-4) 2 ∙ 2H 2 O (4). Unlike 2, compound 3 gives crystals [N(CH 2 CH 2 OH) 3 ] 2 Ni 2+ · [ - OOCCH 2 SC 6 H 4 Cl-4] 2 (5), which have a structure of metallated ionic liquid. The structure of 5 has been proved by X-ray diffraction analysis. It is the first example of the conversion of a protic ionic liquid into potentially biological active metallated ionic liquid (1 → 3 → 5).
Author details: | Anna N. Mirskova, Sergey N. Adamovich, Rudolf G. Mirskov, Uwe SchildeORCiDGND |
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URN: | urn:nbn:de:kobv:517-opus4-401099 |
Subtitle (English): | first conversion of a protic ionic liquid into metallated ionic liquid |
Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (377) |
Publication type: | Postprint |
Language: | English |
Date of first publication: | 2017/10/05 |
Publication year: | 2017 |
Publishing institution: | Universität Potsdam |
Release date: | 2017/10/05 |
Tag: | Acids; Formate; Salts |
Number of pages: | 5 |
Source: | Chemistry Central Journal 7 (2013). - DOI: 10.1186/1752-153X-7-34 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer review: | Referiert |
Publishing method: | Open Access |
Grantor: | BioMed Central |
License (German): | CC-BY - Namensnennung 4.0 International |