Hyaluronic Acid/Poly-l-Lysine Multilayers as Reservoirs for Storage and Release of Small Charged Molecules
- Polyelectrolyte multilayer films are nowadays very attractive for bioapplications due to their tunable properties and ability to control cellular response. Here we demonstrate that multilayers made of hyaluronic acid and poly-l-lysine act as high-capacity reservoirs for small charged molecules. Strong accumulation within the film is explained by electrostatically driven binding to free charges of polyelectrolytes. Binding and release mechanisms are discussed based on charge balance and polymer dynamics in the film. Our results show that transport of molecules through the film-solution interface limits the release rate. The multilayers might serve as an effective platform for drug delivery and tissue engineering due to high potential for drug loading and controlled release.
| Author details: | Vladimir Z. Prokopovic, Claus DuschlORCiD, Dmitry Volodkin |
|---|---|
| DOI: | https://doi.org/10.1002/mabi.201500093 |
| ISSN: | 1616-5187 |
| ISSN: | 1616-5195 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/25981869 |
| Title of parent work (English): | Macromolecular bioscience |
| Publisher: | Wiley-VCH |
| Place of publishing: | Weinheim |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2015 |
| Publication year: | 2015 |
| Release date: | 2017/03/27 |
| Tag: | diffusion; drug delivery; dye; release mechanism |
| Volume: | 15 |
| Issue: | 10 |
| Number of pages: | 7 |
| First page: | 1357 |
| Last Page: | 1363 |
| Funding institution: | Alexander von Humboldt Foundation; DFG [VO 1716/2-1] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer review: | Referiert |
