Biodegradation-Resistant Multilayers Coated with Gold Nanoparticles. Toward a Tailor-made Artificial Extracellular Matrix
- Polymer multicomponent coatings such as multilayers mimic an extracellular, matrix (ECM) that attracts significant attention for the use of the multilayers as functional supports for advanced cell culture and tissue engineering. Herein, biodegradation and molecular transport in hyaluronan/polylysine multilayers coated with gold nanoparticles were described. Nanoparticle coating acts as a semipermeable barrier that governs molecular transport into/from the multilayers, and makes them biodegradation-resistant. Model protein lysozyme (mimics of ECM-soluble signals) diffuses into the multilayers as fast- and, slow-diffusing populations existing in an equilibrium,. Such a. composite system may have high potential to be exploited as degradation-resistant drug-delivery platforms suitable for cell-based applications.
| Author details: | Vladimir Z. Prokopovic, Anna S. Vikulina, David Sustr, Claus DuschlORCiD, Dmitry Volodkin |
|---|---|
| DOI: | https://doi.org/10.1021/acsami.6b10095 |
| ISSN: | 1944-8244 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/27607839 |
| Title of parent work (English): | Journal of colloid and interface science |
| Publisher: | American Chemical Society |
| Place of publishing: | Washington |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2016 |
| Publication year: | 2016 |
| Release date: | 2020/03/22 |
| Tag: | cell adhesion; diffusion; enzymatic degradation; fluorescence recovery after photobleaching; hyaluronic acid; layer-by-layer; polylysine; semipermeable |
| Volume: | 8 |
| Number of pages: | 5 |
| First page: | 24345 |
| Last Page: | 24349 |
| Funding institution: | Alexander von Humboldt Foundation; DFG [VO 1716/2-3] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer review: | Referiert |
