The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors
- Arf-like proteins (ARLs) are ubiquitously expressed small G proteins of the RAS superfamily. In photoreceptors, ARL2 and ARL3 participate in the trafficking of lipidated membrane-associated proteins and colocalize in the inner segment with UNC119A and PDE delta. UNC119A and PDE delta are acyl-and prenyl-binding proteins, respectively, involved in trafficking of acylated (transducin-alpha subunit, nephrocystin NPHP3) and prenylated proteins (GRK1, PDE6). Germline Arl3 knockout mice do not survive beyond postnatal day 21 and display ciliary defects in multiple organs (kidney, liver and pancreas) as well as retinal degeneration. Conditional knockouts will be necessary to delineate mechanisms of protein transport in retina disease.
| Author details: | Christin Hanke-Gogokhia, Houbin ZhangORCiD, Jeanne M. Frederick, Wolfgang BaehrORCiD |
|---|---|
| DOI: | https://doi.org/10.1007/978-3-319-17121-0_87 |
| ISBN: | 978-3-319-17121-0; 978-3-319-17120-3 |
| ISSN: | 0065-2598 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/26427472 |
| Title of parent work (English): | Retinal Degenerative Diseases : Mechanisms and Experimental Therapy |
| Publisher: | Springer International Publishing AG |
| Place of publishing: | Cham |
| Editor(s): | CB Rickman, MM LaVail, RE Anderson, C Grimm, J Hollyfield, J Ash |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2016 |
| Publication year: | 2016 |
| Release date: | 2020/03/22 |
| Tag: | Arf-like protein 2 (ARL2); Arf-like protein 3 (ARL3); Phosphodiesterase delta-subunit (PDE delta); Retinitis pigmentosa protein 2 (RP2); Rod photoreceptor; unc-119 homolog (C. elegans) (UNC119A) |
| Volume: | 854 |
| Number of pages: | 7 |
| First page: | 655 |
| Last Page: | 661 |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer review: | Referiert |
