Synthesis and self-assembly of cytidine- and guanosine-based copolymers
- The base pairing property and the "melting" behavior of oligonucleotides can take advantage to develop new smart thermoresponsive and programmable materials. Complementary cytidine- (C) and guanosine- (G) based monomers were blockcopolymerized using RAFT polymerization technique with poly-(N-(2-hydroxypropyl) methacrylamide) (pHPMA) as the hydrophilic macro chain transfer agent (macro-CTA). C-C, G-G and C-G hydrogen bond interactions of blockcopolymers with respectively C and G moieties have been investigated using SEM, DLS and UV-Vis. Mixing and heating both complementary copolymers resulted in reforming new aggregates. Due to the ribose moiety of the isolated nucleoside-bearing blockcopolymers, the polarity is increased for better solubility. Self-assembly investigations of these bioinspired compounds are the crucial basis for the development of potential future drug delivery systems.
Author details: | Sany CheaORCiDGND, Kristin Schade, Stefan ReinickeORCiDGND, Regina BleulORCiD, Ruben R. RosencrantzORCiDGND |
---|---|
DOI: | https://doi.org/10.1039/d2py00615d |
ISSN: | 1759-9954 |
ISSN: | 1759-9962 |
Title of parent work (English): | Polymer Chemistry |
Publisher: | Royal Society of Chemistry |
Place of publishing: | Cambridge |
Publication type: | Article |
Language: | English |
Date of first publication: | 2022/08/11 |
Publication year: | 2022 |
Release date: | 2023/12/08 |
Volume: | 13 |
Issue: | 35 |
Number of pages: | 11 |
First page: | 5058 |
Last Page: | 5067 |
Funding institution: | Fraunhofer Internal Programs [840 205]; Fraunhofer Cluster of Excellence; Immune-Mediated Diseases CIMD; German Federal Ministry of Education and; Research (BMBF) [13XP5113] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer review: | Referiert |
Publishing method: | Open Access / Hybrid Open-Access |
License (English): | Creative Commons - Namensnennung 3.0 Unported |