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Supramolecular gelatin networks based on inclusion complexes
- Hydrogel forming physical networks based on gelatin are an attractive approach toward multifunctional biomaterials with the option of reshaping, self-healing, and stimuli-sensitivity. However, it is challenging to design such gelatin-based hydrogels to be stable at body temperature. Here, gelatin functionalized with desaminotyrosine (DAT) or desaminotyrosyl tyrosine (DATT) side chains is crosslinked with cyclodextrin (CD) dimers under formation of inclusions complexes. The supramolecular networks displayed at room temperature decreased water uptake (200-600 wt% for DAT-based systems, 200 wt% for DATT based systems), and increased storage moduli up to 25.6 kPa determined by rheology compared to DAT(T) gelatin. The gel-sol transition temperature increased from 33 up to 42 degrees C. The presented system that is completely based on natural building blocks may form the basis for materials that may potentially respond by dissolution or changes of properties to changes in environmental conditions or to the presence of CD guest molecules.
Author details: | Candy LöwenbergGND, Giuseppe TripodoORCiD, Konstanze K. Julich-GrunerGND, Axel T. NeffeORCiDGND, Andreas LendleinORCiDGND |
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DOI: | https://doi.org/10.1002/mabi.202000221 |
ISSN: | 1616-5187 |
ISSN: | 1616-5195 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/32808465 |
Title of parent work (English): | Macromolecular bioscience |
Publisher: | Wiley-VCH |
Place of publishing: | Weinheim |
Publication type: | Article |
Language: | English |
Date of first publication: | 2020/08/17 |
Publication year: | 2020 |
Release date: | 2023/12/14 |
Tag: | cyclodextrin; gelatin; inclusion complex; supramolecular polymer network |
Volume: | 20 |
Issue: | 10 |
Article number: | 2000221 |
Number of pages: | 8 |
Funding institution: | Helmholtz AssociationHelmholtz Association; German Federal Ministry for; Education and Research (BMBF)Federal Ministry of Education & Research; (BMBF) [0315696A]; Projekt DEAL |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer review: | Referiert |
Publishing method: | Open Access / Hybrid Open-Access |
License (German): | CC-BY - Namensnennung 4.0 International |