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Advances in the biofabrication of 3D skin in vitro
- The relevance for in vitro three-dimensional (3D) tissue culture of skin has been present for almost a century. From using skin biopsies in organ culture, to vascularized organotypic full-thickness reconstructed human skin equivalents, in vitro tissue regeneration of 3D skin has reached a golden era. However, the reconstruction of 3D skin still has room to grow and develop. The need for reproducible methodology, physiological structures and tissue architecture, and perfusable vasculature are only recently becoming a reality, though the addition of more complex structures such as glands and tactile corpuscles require advanced technologies. In this review, we will discuss the current methodology for biofabrication of 3D skin models and highlight the advantages and disadvantages of the existing systems as well as emphasize how new techniques can aid in the production of a truly physiologically relevant skin construct for preclinical innovation.
Author details: | Matthew J. RandallORCiD, Astrid Jüngel, Markus RimannORCiD, Karin Wuertz-KozakORCiDGND |
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URN: | urn:nbn:de:kobv:517-opus4-468844 |
DOI: | https://doi.org/10.25932/publishup-46884 |
ISSN: | 1866-8364 |
Title of parent work (German): | Postprints der Universität Potsdam : Humanwissenschaftliche Reihe |
Subtitle (English): | healthy and pathological models |
Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe (680) |
Publication type: | Postprint |
Language: | English |
Date of first publication: | 2020/12/17 |
Publication year: | 2018 |
Publishing institution: | Universität Potsdam |
Release date: | 2020/12/17 |
Tag: | 3D tissue model; biofabrication; bioprinting; electrospinning; preclinical testing; skin; skin disease in vitro |
Issue: | 680 |
Number of pages: | 14 |
Source: | Frontiers in Bioengineering and Biotechnology 6 (2018) 154 DOI: 10.3389/fbioe.2018.00154 |
Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Sport- und Gesundheitswissenschaften |
DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Peer review: | Referiert |
Publishing method: | Open Access / Green Open-Access |
License (German): | CC-BY - Namensnennung 4.0 International |
External remark: | Bibliographieeintrag der Originalveröffentlichung/Quelle |