Laury Sellem, Rona Antoni, Athanasios Koutsos, Ezgi Ozen, Gloria Wong, Hasnaa Ayyad, Michelle Weech, Matthias Bernd Schulze, Andreas Wernitz, Barbara A. Fielding, M. Denise Robertson, Kim G. Jackson, Bruce A. Griffin, Julie A. Lovegrove
- Purpose UK guidelines recommend dietary saturated fatty acids (SFAs) should not exceed 10% total energy (%TE) for cardiovascular disease prevention, with benefits observed when SFAs are replaced with unsaturated fatty acids (UFAs). This study aimed to assess the efficacy of a dietary exchange model using commercially available foods to replace SFAs with UFAs. Methods Healthy men (n = 109, age 48, SD 11 year) recruited to the Reading, Imperial, Surrey, Saturated fat Cholesterol Intervention-1 (RISSCI-1) study (ClinicalTrials.Gov n degrees NCT03270527) followed two sequential 4-week isoenergetic moderate-fat (34%TE) diets: high-SFA (18%TE SFAs, 16%TE UFAs) and low-SFA (10%TE SFAs, 24%TE UFAs). Dietary intakes were assessed using 4-day weighed diet diaries. Nutrient intakes were analysed using paired t-tests, fasting plasma phospholipid fatty acid (PL-FA) profiles and dietary patterns were analysed using orthogonal partial least square discriminant analyses. Results Participants exchanged 10.2%TE (SD 4.1) SFAs for 9.7%TE (SD 3.9) UFAsPurpose UK guidelines recommend dietary saturated fatty acids (SFAs) should not exceed 10% total energy (%TE) for cardiovascular disease prevention, with benefits observed when SFAs are replaced with unsaturated fatty acids (UFAs). This study aimed to assess the efficacy of a dietary exchange model using commercially available foods to replace SFAs with UFAs. Methods Healthy men (n = 109, age 48, SD 11 year) recruited to the Reading, Imperial, Surrey, Saturated fat Cholesterol Intervention-1 (RISSCI-1) study (ClinicalTrials.Gov n degrees NCT03270527) followed two sequential 4-week isoenergetic moderate-fat (34%TE) diets: high-SFA (18%TE SFAs, 16%TE UFAs) and low-SFA (10%TE SFAs, 24%TE UFAs). Dietary intakes were assessed using 4-day weighed diet diaries. Nutrient intakes were analysed using paired t-tests, fasting plasma phospholipid fatty acid (PL-FA) profiles and dietary patterns were analysed using orthogonal partial least square discriminant analyses. Results Participants exchanged 10.2%TE (SD 4.1) SFAs for 9.7%TE (SD 3.9) UFAs between the high and low-SFA diets, reaching target intakes with minimal effect on other nutrients or energy intakes. Analyses of dietary patterns confirmed successful incorporation of recommended foods from commercially available sources (e.g. dairy products, snacks, oils, and fats), without affecting participants' overall dietary intakes. Analyses of plasma PL-FAs indicated good compliance to the dietary intervention and foods of varying SFA content. Conclusions RISSCI-1 dietary exchange model successfully replaced dietary SFAs with UFAs in free-living healthy men using commercially available foods, and without altering their dietary patterns. Further intervention studies are required to confirm utility and feasibility of such food-based dietary fat replacement models at a population level.…
MetadatenAuthor details: | Laury Sellem, Rona Antoni, Athanasios Koutsos, Ezgi Ozen, Gloria Wong, Hasnaa Ayyad, Michelle Weech, Matthias Bernd SchulzeORCiDGND, Andreas Wernitz, Barbara A. Fielding, M. Denise Robertson, Kim G. Jackson, Bruce A. Griffin, Julie A. LovegroveORCiDGND |
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DOI: | https://doi.org/10.1007/s00394-022-02910-2 |
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ISSN: | 1436-6207 |
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ISSN: | 1436-6215 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/35668120 |
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Title of parent work (English): | European journal of nutrition |
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Publisher: | Springer |
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Place of publishing: | Heidelberg |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2022/06/06 |
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Publication year: | 2022 |
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Release date: | 2024/04/25 |
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Tag: | Dairy biomarkers; Dietary compliance; Dietary fat composition; Dietary fat replacement; Food-exchange model |
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Volume: | 61 |
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Issue: | 7 |
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Number of pages: | 16 |
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First page: | 3669 |
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Last Page: | 3684 |
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Funding institution: | Biotechnology and Biological Sciences Research Council (BBSRC); [BB/P010245/1, BB/P009891/1] |
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Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
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DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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| 6 Technik, Medizin, angewandte Wissenschaften / 63 Landwirtschaft / 630 Landwirtschaft und verwandte Bereiche |
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| 6 Technik, Medizin, angewandte Wissenschaften / 64 Hauswirtschaft und Familie / 640 Hauswirtschaft und Familie |
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Peer review: | Referiert |
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Publishing method: | Open Access / Hybrid Open-Access |
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License (German): | CC-BY - Namensnennung 4.0 International |
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