Periodic thermomechanical modulation of toll-like receptor expression and distribution in mesenchymal stromal cells
- Toll-like receptor (TLR) can trigger an immune response against virus including SARS-CoV-2. TLR expression/distribution is varying in mesenchymal stromal cells (MSCs) depending on their culture environments. Here, to explore the effect of periodic thermomechanical cues on TLRs, thermally controlled shape-memory polymer sheets with programmable actuation capacity were created. The proportion of MSCs expressing SARS-CoV-2-associated TLRs was increased upon stimulation. The TLR4/7 colocalization was promoted and retained in the endoplasmic reticula. The TLR redistribution was driven by myosin-mediated F-actin assembly. These results highlight the potential of boosting the immunity for combating COVID-19 via thermomechanical preconditioning of MSCs.
| Verfasserangaben: | Xun Xu, Yan NieORCiDGND, Weiwei WangGND, Nan Ma, Andreas LendleinORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1557/s43579-021-00049-5 |
| ISSN: | 2159-6859 |
| ISSN: | 2159-6867 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/34258101 |
| Titel des übergeordneten Werks (Englisch): | MRS communications / a publication of the Materials Research Society |
| Verlag: | Springer |
| Verlagsort: | Berlin |
| Publikationstyp: | Wissenschaftlicher Artikel |
| Sprache: | Englisch |
| Datum der Erstveröffentlichung: | 08.07.2021 |
| Erscheinungsjahr: | 2021 |
| Datum der Freischaltung: | 08.05.2024 |
| Freies Schlagwort / Tag: | Actuation; Antiviral; Biomaterial; COVID-19; Shape memory |
| Band: | 11 |
| Ausgabe: | 4 |
| Seitenanzahl: | 7 |
| Erste Seite: | 425 |
| Letzte Seite: | 431 |
| Fördernde Institution: | Helmholtz Association of German Research CentersHelmholtz Association [13GW0098]; Federal Ministry of Education and Research, GermanyFederal Ministry of Education & Research (BMBF) [13GW0098] |
| Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| DDC-Klassifikation: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Peer Review: | Referiert |
| Publikationsweg: | Open Access / Hybrid Open-Access |
| Lizenz (Deutsch): |  CC-BY - Namensnennung 4.0 International |
