Highly K+ selective probes with fluorescence emission wavelengths higher than 500 nm in water
- Herein, we report on the synthesis of highly K+/Na+ selective fluorescent probes in a feasible number of synthetic steps. These K+ selective fluorescent probes, so called fluoroionophores, 1 and 2 consists of different highly K+/Na+ selective building blocks the alkoxy-substituted N-phenylaza-18-crown-6 lariat ethers (ionophores) and "green" (cf. coumarin unit in 1) or "red" (cf. nile red unit in 2) fluorescent moieties (fluorophores). The fluorescent probes 1 and 2 show K+ induced fluorescence enhancement factors of 4.1 for 1 and 1.9 for 2 and dissociation constants for the corresponding K+ complexes of 43 mM (1+K+) and 18 mM (2+K+) in buffered aqueous solution. The fluorescence signal of 1 and 2 is changed by less than 5 % by pH values in the range of 6.8 to 8.8. Thus, 1 and 2 are capable fluorescent tools to determine extracellular K+ levels by fluorescence enhancements at wavelengths higher than 500 nm.
Author details: | Thomas SchwarzeORCiD, Janine RiemerORCiDGND |
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DOI: | https://doi.org/10.1002/slct.202003785 |
ISSN: | 2365-6549 |
Title of parent work (English): | ChemistrySelect |
Publisher: | Wiley-VCH |
Place of publishing: | Weinheim |
Publication type: | Article |
Language: | English |
Date of first publication: | 2020/11/16 |
Publication year: | 2020 |
Release date: | 2023/02/02 |
Tag: | fluorescence; potassium; probes; selectivity; sodium |
Volume: | 5 |
Issue: | 42 |
Number of pages: | 5 |
First page: | 13174 |
Last Page: | 13178 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer review: | Referiert |
Publishing method: | Open Access / Hybrid Open-Access |
License (German): | CC-BY - Namensnennung 4.0 International |