On the relation between reactions and complexes of (bio)chemical reaction networks
- Robustness of biochemical systems has become one of the central questions in systems biology although it is notoriously difficult to formally capture its multifaceted nature. Maintenance of normal system function depends not only on the stoichiometry of the underlying interrelated components, but also on the multitude of kinetic parameters. Invariant flux ratios, obtained within flux coupling analysis, as well as invariant complex ratios, derived within chemical reaction network theory, can characterize robust properties of a system at steady state. However, the existing formalisms for the description of these invariants do not provide full characterization as they either only focus on the flux-centric or the concentration-centric view. Here we develop a novel mathematical framework which combines both views and thereby overcomes the limitations of the classical methodologies. Our unified framework will be helpful in analyzing biologically important system properties.
Author details: | Jost Neigenfind, Sergio Grimbs, Zoran NikoloskiORCiDGND |
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DOI: | https://doi.org/10.1016/j.jtbi.2012.10.016 |
ISSN: | 0022-5193 |
Title of parent work (English): | Journal of theoretical biology |
Publisher: | Elsevier |
Place of publishing: | London |
Publication type: | Article |
Language: | English |
Year of first publication: | 2013 |
Publication year: | 2013 |
Release date: | 2017/03/26 |
Tag: | Chemical reaction network theory; Flux coupling analysis; Mass action system; Metabolic network |
Volume: | 317 |
Issue: | 2 |
Number of pages: | 7 |
First page: | 359 |
Last Page: | 365 |
Funding institution: | Max-Planck Society; ColoNET project; Federal Ministry of Education and Research [0315417F] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
Peer review: | Referiert |