Growth-Regulating Factors (GRFs): A Small Transcription Factor Family with Important Functions in Plant Biology
- Growth-regulating factors (GRFs) are plant-specific transcription factors that were originally identified for their roles in stem and leaf development, but recent studies highlight them to be similarly important for other central developmental processes including flower and seed formation, root development, and the coordination of growth processes under adverse environmental conditions. The expression of several GRFs is controlled by microRNA miR396, and the GRF-miRNA396 regulatory module appears to be central to several of these processes. In addition, transcription factors upstream of GRFs and miR396 have been discovered, and gradually downstream target genes of GRFs are being unraveled. Here, we review the current knowledge of the biological functions performed by GRFs and survey available molecular data to illustrate how they exert their roles at the cellular level.
Author details: | Mohammad Amin OmidbakhshfardORCiDGND, Sebastian ProostORCiD, Ushio Fujikura, Bernd Müller-RöberORCiDGND |
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DOI: | https://doi.org/10.1016/j.molp.2015.01.013 |
ISSN: | 1674-2052 |
ISSN: | 1752-9867 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/25620770 |
Title of parent work (English): | Molecular plant |
Publisher: | Cell Press |
Place of publishing: | Cambridge |
Publication type: | Article |
Language: | English |
Year of first publication: | 2015 |
Publication year: | 2015 |
Release date: | 2017/03/27 |
Tag: | abiotic stress; chromatin remodeling; flower development; growth regulation; leaf development; miRNA |
Volume: | 8 |
Issue: | 7 |
Number of pages: | 13 |
First page: | 998 |
Last Page: | 1010 |
Funding institution: | University of Potsdam; German Research Foundation (DFG) [FOR 948, MU 1199/14-2] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
Peer review: | Referiert |