Periodic thermomechanical modulation of toll-like receptor expression and distribution in mesenchymal stromal cells
- Toll-like receptor (TLR) can trigger an immune response against virus including SARS-CoV-2. TLR expression/distribution is varying in mesenchymal stromal cells (MSCs) depending on their culture environments. Here, to explore the effect of periodic thermomechanical cues on TLRs, thermally controlled shape-memory polymer sheets with programmable actuation capacity were created. The proportion of MSCs expressing SARS-CoV-2-associated TLRs was increased upon stimulation. The TLR4/7 colocalization was promoted and retained in the endoplasmic reticula. The TLR redistribution was driven by myosin-mediated F-actin assembly. These results highlight the potential of boosting the immunity for combating COVID-19 via thermomechanical preconditioning of MSCs.
| Author details: | Xun Xu, Yan NieORCiDGND, Weiwei WangGND, Nan Ma, Andreas LendleinORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1557/s43579-021-00049-5 |
| ISSN: | 2159-6859 |
| ISSN: | 2159-6867 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/34258101 |
| Title of parent work (English): | MRS communications / a publication of the Materials Research Society |
| Publisher: | Springer |
| Place of publishing: | Berlin |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2021/07/08 |
| Publication year: | 2021 |
| Release date: | 2024/05/08 |
| Tag: | Actuation; Antiviral; Biomaterial; COVID-19; Shape memory |
| Volume: | 11 |
| Issue: | 4 |
| Number of pages: | 7 |
| First page: | 425 |
| Last Page: | 431 |
| Funding institution: | Helmholtz Association of German Research CentersHelmholtz Association [13GW0098]; Federal Ministry of Education and Research, GermanyFederal Ministry of Education & Research (BMBF) [13GW0098] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Peer review: | Referiert |
| Publishing method: | Open Access / Hybrid Open-Access |
| License (German): |  CC-BY - Namensnennung 4.0 International |
