Lipid Biomarkers in Depression: Does Antidepressant Therapy Have an Impact?
- Studies have revealed mixed results on how antidepressant drugs affect lipid profiles of patients with major depression disorder (MDD). Even less is known about how patients respond to a switch of antidepressant medication with respect to their metabolic profile. For this, effects of a switch in antidepressants medication on lipid markers were studied in MDD patients. 15 participants (females = 86.67%; males = 13.33%; age: 49.45 ± 7.45 years) with MDD and a prescribed switch in their antidepressant medication were recruited at a psychosomatic rehabilitation clinic. Participants were characterized (with questionnaires and blood samples) at admission to the rehabilitation clinic (baseline, T0) and followed up with a blood sample two weeks (T1) later. HDL, LDL, total cholesterol, and triglycerides were determined (T0), and their change analyzed (Wilcoxon test) at follow up (T1). Decrements in HDL (p = 0.041), LDL (p < 0.001), and total cholesterol (p < 0.001) were observed two weeks after a switch in antidepressant medication.Studies have revealed mixed results on how antidepressant drugs affect lipid profiles of patients with major depression disorder (MDD). Even less is known about how patients respond to a switch of antidepressant medication with respect to their metabolic profile. For this, effects of a switch in antidepressants medication on lipid markers were studied in MDD patients. 15 participants (females = 86.67%; males = 13.33%; age: 49.45 ± 7.45 years) with MDD and a prescribed switch in their antidepressant medication were recruited at a psychosomatic rehabilitation clinic. Participants were characterized (with questionnaires and blood samples) at admission to the rehabilitation clinic (baseline, T0) and followed up with a blood sample two weeks (T1) later. HDL, LDL, total cholesterol, and triglycerides were determined (T0), and their change analyzed (Wilcoxon test) at follow up (T1). Decrements in HDL (p = 0.041), LDL (p < 0.001), and total cholesterol (p < 0.001) were observed two weeks after a switch in antidepressant medication. Triglycerides showed no difference (p = 0.699). Overall, LDL, HDL, and total cholesterol are affected by a change in antidepressant drugs in patients with MDD. These observations are of clinical relevance for medical practitioners in the planning and management of treatment strategies for MDD patients.…
| Author details: | Fidelis Christin Stuchtey, Andrea BlockORCiDGND, Francis OseiORCiD, Pia-Maria WippertORCiDGND |
|---|---|
| DOI: | https://doi.org/10.3390/healthcare10020333 |
| ISSN: | 2227-9032 |
| Title of parent work (English): | Healthcare : open access journal |
| Publisher: | MDPI |
| Place of publishing: | Basel, Schweiz |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2022/02/09 |
| Publication year: | 2022 |
| Release date: | 2022/09/12 |
| Tag: | HDL; LDL; antidepressants; cholesterol; high density lipoprotein cholesterol; lipids; low density lipoprotein cholesterol; major depressive disorder; triglycerides |
| Volume: | 10 |
| Article number: | 333 |
| Print run: | 2 |
| Number of pages: | 11 |
| First page: | 1 |
| Last Page: | 11 |
| Organizational units: | Extern / Extern |
| Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften | |
| DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Peer review: | Referiert |
| Grantor: | Publikationsfonds der Universität Potsdam |
| Publishing method: | Open Access / Gold Open-Access |
| License (German): |  CC-BY - Namensnennung 4.0 International |
| External remark: | Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Humanwissenschaftliche Reihe ; 776 |
