Felix Boekstegers, Katherine Marcelain, Carol Barahona Ponce, Pablo F. Baez Benavides, Bettina Müller, Gonzalo de Toro, Javier Retamales, Olga Barajas, Monica Ahumada, Krasimira Aleksandrova, Justo Lorenzo Bermejo
- Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence.
Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication.
Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low.
Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improveBackground: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence.
Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication.
Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low.
Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.…
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MetadatenVerfasserangaben: | Felix BoekstegersORCiDGND, Katherine MarcelainORCiD, Carol Barahona PonceORCiDGND, Pablo F. Baez BenavidesORCiD, Bettina MüllerORCiD, Gonzalo de Toro, Javier RetamalesORCiD, Olga BarajasORCiD, Monica AhumadaORCiD, Krasimira AleksandrovaORCiDGND, Justo Lorenzo BermejoORCiDGND |
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URN: | urn:nbn:de:kobv:517-opus4-526833 |
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DOI: | https://doi.org/10.25932/publishup-52683 |
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ISSN: | 1866-8372 |
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Titel des übergeordneten Werks (Deutsch): | Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe |
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Schriftenreihe (Bandnummer): | Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (1204) |
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Publikationstyp: | Postprint |
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Sprache: | Englisch |
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Erscheinungsjahr: | 2020 |
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Veröffentlichende Institution: | Universität Potsdam |
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Datum der Freischaltung: | 17.11.2021 |
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Freies Schlagwort / Tag: | cancer epidemiology; gallbladder cancer; native American ancestry; population-specific risk marker |
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Aufsatznummer: | 101643 |
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Seitenanzahl: | 7 |
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Quelle: | Cancer Epidemiology, Volume 65, 2020, 101643, ISSN 1877-7821, https://doi.org/10.1016/j.canep.2019.101643 |
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Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
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DDC-Klassifikation: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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Peer Review: | Referiert |
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Publikationsweg: | Open Access / Green Open-Access |
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Lizenz (Deutsch): | CC-BY - Namensnennung 4.0 International |
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Externe Anmerkung: | Bibliographieeintrag der Originalveröffentlichung/Quelle |
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