Felix Boekstegers, Katherine Marcelain, Carol Barahona Ponce, Pablo F. Baez Benavides, Bettina Müller, Gonzalo de Toro, Javier Retamales, Olga Barajas, Monica Ahumada, Krasimira Aleksandrova, Justo Lorenzo Bermejo
- Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence.
Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication.
Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low.
Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improveBackground: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence.
Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication.
Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low.
Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.…
MetadatenAuthor details: | Felix BoekstegersORCiDGND, Katherine MarcelainORCiD, Carol Barahona PonceORCiDGND, Pablo F. Baez BenavidesORCiD, Bettina MüllerORCiD, Gonzalo de Toro, Javier RetamalesORCiD, Olga BarajasORCiD, Monica AhumadaORCiD, Krasimira AleksandrovaORCiDGND, Justo Lorenzo BermejoORCiDGND |
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URN: | urn:nbn:de:kobv:517-opus4-526833 |
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DOI: | https://doi.org/10.25932/publishup-52683 |
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ISSN: | 1866-8372 |
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Title of parent work (German): | Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe |
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Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (1204) |
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Publication type: | Postprint |
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Language: | English |
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Publication year: | 2020 |
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Publishing institution: | Universität Potsdam |
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Release date: | 2021/11/17 |
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Tag: | cancer epidemiology; gallbladder cancer; native American ancestry; population-specific risk marker |
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Article number: | 101643 |
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Number of pages: | 7 |
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Source: | Cancer Epidemiology, Volume 65, 2020, 101643, ISSN 1877-7821, https://doi.org/10.1016/j.canep.2019.101643 |
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Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
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DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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Peer review: | Referiert |
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Publishing method: | Open Access / Green Open-Access |
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License (German): | CC-BY - Namensnennung 4.0 International |
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External remark: | Bibliographieeintrag der Originalveröffentlichung/Quelle |
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