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Enzymatically triggered Jack-in-the-box-like hydrogels
- Enzymes can support the synthesis or degradation of biomacromolecules in natural processes. Here, we demonstrate that enzymes can induce a macroscopic-directed movement of microstructured hydrogels following a mechanism that we call a "Jack-in-the-box" effect. The material's design is based on the formation of internal stresses induced by a deformation load on an architectured microscale, which are kinetically frozen by the generation of polyester locking domains, similar to a Jack-in-thebox toy (i.e., a compressed spring stabilized by a closed box lid). To induce the controlled macroscopic movement, the locking domains are equipped with enzyme-specific cleavable bonds (i.e., a box with a lock and key system). As a result of enzymatic reaction, a transformed shape is achieved by the release of internal stresses. There is an increase in entropy in combination with a swelling-supported stretching of polymer chains within the microarchitectured hydrogel (i.e., the encased clown pops-up with a pre-stressed movement when the box isEnzymes can support the synthesis or degradation of biomacromolecules in natural processes. Here, we demonstrate that enzymes can induce a macroscopic-directed movement of microstructured hydrogels following a mechanism that we call a "Jack-in-the-box" effect. The material's design is based on the formation of internal stresses induced by a deformation load on an architectured microscale, which are kinetically frozen by the generation of polyester locking domains, similar to a Jack-in-thebox toy (i.e., a compressed spring stabilized by a closed box lid). To induce the controlled macroscopic movement, the locking domains are equipped with enzyme-specific cleavable bonds (i.e., a box with a lock and key system). As a result of enzymatic reaction, a transformed shape is achieved by the release of internal stresses. There is an increase in entropy in combination with a swelling-supported stretching of polymer chains within the microarchitectured hydrogel (i.e., the encased clown pops-up with a pre-stressed movement when the box is unlocked). This utilization of an enzyme as a physiological stimulus may offer new approaches to create interactive and enzyme-specific materials for different applications such as an optical indicator of the enzyme's presence or actuators and sensors in biotechnology and in fermentation processes.…
Verfasserangaben: | Maria BalkGND, Marc BehlORCiDGND, Ulrich NöchelGND, Andreas LendleinORCiDGND |
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DOI: | https://doi.org/10.1021/acsami.1c00466 |
ISSN: | 1944-8244 |
ISSN: | 1944-8252 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/33555174 |
Titel des übergeordneten Werks (Englisch): | ACS applied materials & interfaces / American Chemical Society |
Verlag: | American Chemical Society |
Verlagsort: | Washington, DC |
Publikationstyp: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Datum der Erstveröffentlichung: | 08.02.2021 |
Erscheinungsjahr: | 2021 |
Datum der Freischaltung: | 03.01.2024 |
Freies Schlagwort / Tag: | enzyme; hydrogels; microporous; poly(e-caprolactone); shape change; stimuli-sensitive materials; switch |
Band: | 13 |
Ausgabe: | 7 |
Seitenanzahl: | 7 |
Erste Seite: | 8095 |
Letzte Seite: | 8101 |
Fördernde Institution: | Helmholtz Association through program-oriented funding Helmholtz Association; Tianjin University-Helmholtz-Zentrum Geesthacht; Joint Laboratory for Biomaterials and Regenerative Medicine by the German Federal Ministry of Education and Research (BMBF)Federal Ministry of Education & Research (BMBF) [0315496]; Chinese Ministry of Science and Technology (MOST)Ministry of Science and Technology, China [2008DFA51170] |
Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC-Klassifikation: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
6 Technik, Medizin, angewandte Wissenschaften / 60 Technik / 600 Technik, Technologie | |
Peer Review: | Referiert |
Publikationsweg: | Open Access / Hybrid Open-Access |