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How do 'housekeeping' genes control organogenesis?-unexpected new findings on the role of housekeeping genes in cell and organ differentiation

  • In recent years, an increasing number of mutations in what would appear to be 'housekeeping genes' have been identified as having unexpectedly specific defects in multicellular organogenesis. This is also the case for organogenesis in seed plants. Although it is not surprising that loss-of-function mutations in 'housekeeping' genes result in lethality or growth retardation, it is surprising when (1) the mutant phenotype results from the loss of function of a 'housekeeping' gene and (2) the mutant phenotype is specific. In this review, by defining housekeeping genes as those encoding proteins that work in basic metabolic and cellular functions, we discuss unexpected links between housekeeping genes and specific developmental processes. In a surprising number of cases housekeeping genes coding for enzymes or proteins with functions in basic cellular processes such as transcription, post-transcriptional modification, and translation affect plant development.

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Author:Hirokazu Tsukaya, Mary E. Byrne, Gorou Horiguchi, Munetaka Sugiyama, Mieke Van Lijsebettens, Michael Lenhard
ISSN:0918-9440 (print)
Parent Title (English):Journal of plant research
Place of publication:Tokyo
Document Type:Article
Year of first Publication:2013
Year of Completion:2013
Release Date:2017/03/26
Tag:3 '-end processing; Development; Housekeeping genes; Post-transcriptional modification; Pre-mRNA splicing; RNAPII; Ribosome; Transcription; Translation
First Page:3
Last Page:15
Funder:University of Sydney; Deutsche Forschungsgemeinschaft [Le1412-3/1]; Institute for the Promotion of Innovation through Science and Technology in Flanders; FP7-Marie Curie programme for IEF fellowship [MC-273068]; [18GS0313]; [19060002]; [19060001]; [17207005]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer Review:Referiert