Yalcin Duydu, Nursen Basaran, Can Özgür Yalcin, Aylin Ustundag, Sevtap Aydin, Hatice Gul Anlar, Merve Bacanli, Kaan Aydos, Cem Somer Atabekoglu, Klaus Golka, Katja Ickstadt, Tanja Schwerdtle, Matthias Werner, Hermann M. Bolt
- Boron-associated shifts in sex ratios at birth were suggested earlier and attributed to a decrease in Y- vs. X-bearing sperm cells. As the matter is pivotal in the discussion of reproductive toxicity of boron/borates, re-investigation in a highly borate-exposed population was required. In the present study, 304 male workers in Bandirma and Bigadic (Turkey) with different degrees of occupational and environmental exposure to boron were investigated. Boron was quantified in blood, urine and semen, and the persons were allocated to exposure groups along B blood levels. In the highest ("extreme") exposure group (n = 69), calculated mean daily boron exposures, semen boron and blood boron concentrations were 44.91 +/- 18.32 mg B/day, 1643.23 +/- 965.44 ng B/g semen and 553.83 +/- 149.52 ng B/g blood, respectively. Overall, an association between boron exposure and Y:X sperm ratios in semen was not statistically significant (p > 0.05). Also, the mean Y:X sperm ratios in semen samples of workers allocated to the different exposure groups wereBoron-associated shifts in sex ratios at birth were suggested earlier and attributed to a decrease in Y- vs. X-bearing sperm cells. As the matter is pivotal in the discussion of reproductive toxicity of boron/borates, re-investigation in a highly borate-exposed population was required. In the present study, 304 male workers in Bandirma and Bigadic (Turkey) with different degrees of occupational and environmental exposure to boron were investigated. Boron was quantified in blood, urine and semen, and the persons were allocated to exposure groups along B blood levels. In the highest ("extreme") exposure group (n = 69), calculated mean daily boron exposures, semen boron and blood boron concentrations were 44.91 +/- 18.32 mg B/day, 1643.23 +/- 965.44 ng B/g semen and 553.83 +/- 149.52 ng B/g blood, respectively. Overall, an association between boron exposure and Y:X sperm ratios in semen was not statistically significant (p > 0.05). Also, the mean Y:X sperm ratios in semen samples of workers allocated to the different exposure groups were statistically not different in pairwise comparisons (p > 0.05). Additionally, a boron-associated shift in sex ratio at birth towards female offspring was not visible. In essence, the present results do not support an association between boron exposure and decreased Y:X sperm ratio in males, even under extreme boron exposure conditions.…
MetadatenAuthor details: | Yalcin DuyduORCiD, Nursen Basaran, Can Özgür YalcinORCiD, Aylin Ustundag, Sevtap Aydin, Hatice Gul Anlar, Merve Bacanli, Kaan Aydos, Cem Somer Atabekoglu, Klaus GolkaORCiDGND, Katja Ickstadt, Tanja SchwerdtleORCiDGND, Matthias Werner, Hermann M. BoltORCiDGND |
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DOI: | https://doi.org/10.1007/s00204-019-02391-z |
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ISSN: | 0340-5761 |
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ISSN: | 1432-0738 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30659322 |
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Title of parent work (English): | Archives of toxicology : official journal of EUROTOX |
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Subtitle (English): | no change in sperm Y:X chromosome ratio and in offspring's sex ratio |
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Publisher: | Springer |
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Place of publishing: | Heidelberg |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2019/01/18 |
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Publication year: | 2019 |
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Release date: | 2021/03/23 |
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Tag: | Boron exposure; Paternal exposure; Sex ratio at birth; Y:X chromosome ratio |
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Volume: | 93 |
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Issue: | 3 |
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Number of pages: | 9 |
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First page: | 743 |
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Last Page: | 751 |
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Funding institution: | Eti Mine Works General ManagementMinistry of Energy & Natural Resources - Turkey; BORENMinistry of Energy & Natural Resources - Turkey [2008-G0207]; Eti Mine Works General Management (2014-2017) |
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Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
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DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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Peer review: | Referiert |
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