Thiol-Thioester exchange reactions in precursors enable pH-triggered hydrogel formation
- Bio-interactive hydrogel formation in situ requires sensory capabilities toward physiologically relevant stimuli. Here, we report on pH-controlled in situ hydrogel formation relying on latent cross-linkers, which transform from pH sensors to reactive molecules. In particular, thiopeptolide/thio-depsipeptides were capable of pH-sensitive thiol-thioester exchange reactions to yield a,co-dithiols, which react with maleimide-functionalized multi-arm polyethylene glycol to polymer networks. Their water solubility and diffusibility qualify thiol/thioester-containing peptide mimetics as sensory precursors to drive in situ localized hydrogel formation with potential applications in tissue regeneration such as treatment of inflamed tissues of the urinary tract.
| Verfasserangaben: | Makafui Yao FolikumahORCiD, Marc BehlORCiDGND, Andreas LendleinORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1021/acs.biomac.0c01690 |
| ISSN: | 1525-7797 |
| ISSN: | 1526-4602 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/33724816 |
| Titel des übergeordneten Werks (Englisch): | Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences |
| Verlag: | American Chemical Society |
| Verlagsort: | Washington |
| Publikationstyp: | Wissenschaftlicher Artikel |
| Sprache: | Englisch |
| Datum der Erstveröffentlichung: | 16.03.2021 |
| Erscheinungsjahr: | 2021 |
| Datum der Freischaltung: | 30.11.2023 |
| Band: | 22 |
| Ausgabe: | 5 |
| Seitenanzahl: | 10 |
| Erste Seite: | 1875 |
| Letzte Seite: | 1884 |
| Fördernde Institution: | Helmholtz AssociationHelmholtz Association; Helmholtz Association through Helmholtz Graduate School of Macromolecular Bioscience (MacroBio) [VH-GS-503] |
| Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| DDC-Klassifikation: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Peer Review: | Referiert |
| Publikationsweg: | Open Access / Hybrid Open-Access |
