Co-deposition of a hydrogel/calcium phosphate hybrid layer on 3D printed poly(lactic acid) scaffolds via dip coating
- The article describes the surface modification of 3D printed poly(lactic acid) (PLA) scaffolds with calcium phosphate (CP)/gelatin and CP/chitosan hybrid coating layers. The presence of gelatin or chitosan significantly enhances CP co-deposition and adhesion of the mineral layer on the PLA scaffolds. The hydrogel/CP coating layers are fairly thick and the mineral is a mixture of brushite, octacalcium phosphate, and hydroxyapatite. Mineral formation is uniform throughout the printed architectures and all steps (printing, hydrogel deposition, and mineralization) are in principle amenable to automatization. Overall, the process reported here therefore has a high application potential for the controlled synthesis of biomimetic coatings on polymeric biomaterials.
| Author details: | Matthias Schneider, Christina GünterGND, Andreas TaubertORCiDGND |
|---|---|
| DOI: | https://doi.org/10.3390/polym10030275 |
| ISSN: | 2073-4360 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30966310 |
| Title of parent work (English): | Polymers |
| Subtitle (English): | Towards Automated Biomaterials Fabrication |
| Publisher: | MDPI |
| Place of publishing: | Basel |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2018/03/07 |
| Publication year: | 2018 |
| Release date: | 2022/01/11 |
| Tag: | 3D printing; PLA; biomaterials; calcium phosphate; calcium phosphate hybrid material; chitosan; dip-coating; gelatin; hydrogel; poly(lactic acid) |
| Volume: | 10 |
| Issue: | 3 |
| Number of pages: | 19 |
| Funding institution: | University of Potsdam (UP) |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Peer review: | Referiert |
| Publishing method: | Open Access / Gold Open-Access |
| DOAJ gelistet | |
| License (German): |  CC-BY - Namensnennung 4.0 International |
| External remark: | Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe ; 1057 |
