BMP signaling in vascular biology and dysfunction
- The vascular system is critical for developmental growth, tissue homeostasis and repair but also for tumor development. Bone morphogenetic protein (BMP) signaling has recently emerged as a fundamental pathway of the endothelium by regulating cardiovascular and lymphatic development and by being causative for several vascular dysfunctions. Two vascular disorders have been directly linked to impaired BMP signaling: pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia. Endothelial BMP signaling critically depends on the cellular context, which includes among others vascular heterogeneity, exposure to flow, and the intertwining with other signaling cascades (Notch, WNT, Hippo and hypoxia). The purpose of this review is to highlight the most recent findings illustrating the clear need for reconsidering the role of BMPs in vascular biology. (C) 2015 Elsevier Ltd. All rights reserved.
Author details: | Amaya Garcia de Vinuesa, Salim Abdelilah-SeyfriedORCiDGND, Petra Knaus, An Zwijsen, Sabine Bailly |
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DOI: | https://doi.org/10.1016/j.cytogfr.2015.12.005 |
ISSN: | 1359-6101 |
ISSN: | 1879-0305 |
Title of parent work (English): | New journal of physics : the open-access journal for physics |
Publisher: | Elsevier |
Place of publishing: | Oxford |
Publication type: | Review |
Language: | English |
Year of first publication: | 2016 |
Publication year: | 2016 |
Release date: | 2020/03/22 |
Tag: | Bone morphogenetic proteins (BMP); Development; Disease; Signaling; Vasculature |
Volume: | 27 |
Number of pages: | 15 |
First page: | 65 |
Last Page: | 79 |
Funding institution: | Dutch Arthritis Association (Reumafonds); excellence cluster REBIRTH; DFG [SE 2016/8-1]; INSERM; CEA; Universite Grenoble-Alpes (UGA); Association pour la Recherche sur le Cancer; Ligue Contre le Cancer de la Loire et de la Savoie; Association Maladie de Rendu-Osler (AMRO); [FWO-VG.0542.13]; [GOA011 /012] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
Peer review: | Referiert |