Metabolic health in normal-weight and obese individuals
- Cardiovascular complications are commonly associated with obesity. However, a subgroup of obese individuals may not be at an increased risk for cardiovascular complications; these individuals are said to have metabolically healthy obesity (MHO). In contrast, metabolically unhealthy individuals are at high risk of cardiovascular disease (CVD), irrespective of BMI; thus, this group can include individuals within the normal weight category (BMI 18.5-24.9kg/m(2)). This review provides a summary of prospective studies on MHO and metabolically unhealthy normal-weight (MUHNW) phenotypes. Notably, there is ongoing dispute surrounding the concept of MHO, including the lack of a uniform definition and the potentially transient nature of metabolic health status. This review highlights the relevance of alternative measures of body fatness, specifically measures of fat distribution, for determining MHO and MUHNW. It also highlights alternative approaches of risk stratification, which account for the continuum of risk in relation to CVD, which isCardiovascular complications are commonly associated with obesity. However, a subgroup of obese individuals may not be at an increased risk for cardiovascular complications; these individuals are said to have metabolically healthy obesity (MHO). In contrast, metabolically unhealthy individuals are at high risk of cardiovascular disease (CVD), irrespective of BMI; thus, this group can include individuals within the normal weight category (BMI 18.5-24.9kg/m(2)). This review provides a summary of prospective studies on MHO and metabolically unhealthy normal-weight (MUHNW) phenotypes. Notably, there is ongoing dispute surrounding the concept of MHO, including the lack of a uniform definition and the potentially transient nature of metabolic health status. This review highlights the relevance of alternative measures of body fatness, specifically measures of fat distribution, for determining MHO and MUHNW. It also highlights alternative approaches of risk stratification, which account for the continuum of risk in relation to CVD, which is observable for most risk factors. Moreover, studies evaluating the transition from metabolically healthy to unhealthy phenotypes and potential determinants for such conversions are discussed. Finally, the review proposes several strategies for the use of epidemiological research to further inform the current debate on metabolic health and its determination across different stages of body fatness.…
Author details: | Matthias Bernd SchulzeORCiDGND |
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DOI: | https://doi.org/10.1007/s00125-018-4787-8 |
ISSN: | 0012-186X |
ISSN: | 1432-0428 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30569272 |
Title of parent work (English): | Diabetologia : journal of the European Association for the Study of Diabetes (EASD) |
Publisher: | Springer |
Place of publishing: | New York |
Publication type: | Review |
Language: | English |
Date of first publication: | 0208/12/19 |
Publication year: | 2018 |
Release date: | 2021/06/21 |
Tag: | Cardiovascular diseases; Cohort studies; Metabolically benign; Obesity; Review |
Volume: | 62 |
Issue: | 4 |
Number of pages: | 9 |
First page: | 558 |
Last Page: | 566 |
Funding institution: | German Ministry of Education and Research (BMBF)Federal Ministry of Education & Research (BMBF); State of Brandenburg (DZD) [82DZD00302] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Peer review: | Referiert |
Publishing method: | Open Access / Hybrid Open-Access |
License (German): | CC-BY - Namensnennung 4.0 International |