Tibor Hortobágyi, Tomas Vetrovsky, Guilherme Moraes Balbim, Narlon Cassio Boa Sorte Silva, Andrea Manca, Franca Deriu, Mia Kolmos, Christina Kruuse, Teresa Liu-Ambrose, Zsolt Radak, Mark Vaczi, Hanna Johansson, Paulo Cezar Rocha dos Santos, Erika Franzen, Urs Granacher
- Objective: To determine the effects of low- vs. high-intensity aerobic and resistance training on motor and cognitive function, brain activation, brain structure, and neurochemical markers of neuroplasticity and the association thereof in healthy young and older adults and in patients with multiple sclerosis, Parkinson's disease, and stroke. Design: Systematic review and robust variance estimation meta-analysis with meta-regression. Data sources: Systematic search of MEDLINE, Web of Science, and CINAHL databases. Results: Fifty studies with 60 intervention arms and 2283 in-analyses participants were included. Due to the low number of studies, the three patient groups were combined and analyzed as a single group. Overall, low- (g=0.19, p = 0.024) and high-intensity exercise (g=0.40, p = 0.001) improved neuroplasticity. Exercise intensity scaled with neuroplasticity only in healthy young adults but not in healthy older adults or patient groups. Exercise-induced improvements in neuroplasticity were associated with changes in motor butObjective: To determine the effects of low- vs. high-intensity aerobic and resistance training on motor and cognitive function, brain activation, brain structure, and neurochemical markers of neuroplasticity and the association thereof in healthy young and older adults and in patients with multiple sclerosis, Parkinson's disease, and stroke. Design: Systematic review and robust variance estimation meta-analysis with meta-regression. Data sources: Systematic search of MEDLINE, Web of Science, and CINAHL databases. Results: Fifty studies with 60 intervention arms and 2283 in-analyses participants were included. Due to the low number of studies, the three patient groups were combined and analyzed as a single group. Overall, low- (g=0.19, p = 0.024) and high-intensity exercise (g=0.40, p = 0.001) improved neuroplasticity. Exercise intensity scaled with neuroplasticity only in healthy young adults but not in healthy older adults or patient groups. Exercise-induced improvements in neuroplasticity were associated with changes in motor but not cognitive outcomes. Conclusion: Exercise intensity is an important variable to dose and individualize the exercise stimulus for healthy young individuals but not necessarily for healthy older adults and neurological patients. This conclusion warrants caution because studies are needed that directly compare the effects of low- vs. high-intensity exercise on neuroplasticity to determine if such changes are mechanistically and incrementally linked to improved cognition and motor function.…
MetadatenAuthor details: | Tibor HortobágyiORCiD, Tomas Vetrovsky, Guilherme Moraes Balbim, Narlon Cassio Boa Sorte Silva, Andrea Manca, Franca Deriu, Mia Kolmos, Christina KruuseORCiD, Teresa Liu-Ambrose, Zsolt Radak, Mark Vaczi, Hanna Johansson, Paulo Cezar Rocha dos SantosORCiD, Erika Franzen, Urs GranacherORCiDGND |
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DOI: | https://doi.org/10.1016/j.arr.2022.101698 |
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ISSN: | 1568-1637 |
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ISSN: | 1872-9649 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/35853549 |
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Title of parent work (English): | Ageing research reviews : ARR |
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Publisher: | Elsevier |
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Place of publishing: | Clare |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2022/07/16 |
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Publication year: | 2022 |
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Release date: | 2024/01/22 |
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Tag: | Aging; Cognition motor; Exercise; Intensity Dose -response relationship; function |
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Volume: | 80 |
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Article number: | 101698 |
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Number of pages: | 18 |
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Funding institution: | Deltaplan Dementie [733050303]; University Medical Center Groningen; [CDO17.0023-2017-2-316]; Cooperatio Program, research area Sport; Sciences -Biomedical & Rehabilitation Medicine; Italian Foundation for; Multiple Sclerosis [FISM 2020_R-Single_028, FISM 2018_R-9]; Michael; Smith Health Research BC; Pacific Alzheimer Research Foundation;; Canadian Institutes of Health Research |
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Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften |
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DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Peer review: | Referiert |
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Publishing method: | Open Access / Hybrid Open-Access |
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License (German): | CC-BY - Namensnennung 4.0 International |
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