Maria Garbusow, Stephan Nebe, Christian Sommer, Sören Kuitunen-Paul, Miriam Sebold, Daniel Schad, Eva Friedel, Ilya M. Veer, Hans-Ulrich Wittchen, Michael A. Rapp, Stephan Ripke, Henrik Walter, Quentin J. M. Huys, Florian Schlagenhauf, Michael N. Smolka, Andreas Heinz
- In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards wasIn animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards was influenced by background Pavlovian conditioned stimuli predicting action-independent rewards and losses. Behavioral PIT was enhanced in high-compared to low-risk drinkers (b = 0.09, SE = 0.03, z = 2.7, p < 0.009). Across all subjects, we observed PIT-related neural blood oxygen level-dependent (BOLD) signal in the right amygdala (t = 3.25, p(SVC) = 0.04, x = 26, y = -6, z = -12), but not in NAcc. The strength of the behavioral PIT effect was positively correlated with polygenic risk for alcohol consumption (r(s) = 0.17, p = 0.032). We conclude that behavioral PIT and polygenic risk for alcohol consumption might be a biomarker for a subclinical phenotype of risky alcohol consumption, even if no drug-related stimulus is present. The association between behavioral PIT effects and the amygdala might point to habitual processes related to out PIT task. In non-dependent young social drinkers, the amygdala rather than the NAcc is activated during PIT; possible different involvement in association with disease trajectory should be investigated in future studies.…
MetadatenAuthor details: | Maria GarbusowORCiDGND, Stephan NebeORCiD, Christian SommerORCiD, Sören Kuitunen-PaulORCiDGND, Miriam SeboldORCiDGND, Daniel SchadORCiDGND, Eva Friedel, Ilya M. Veer, Hans-Ulrich WittchenORCiDGND, Michael A. RappORCiDGND, Stephan RipkeORCiD, Henrik WalterORCiD, Quentin J. M. HuysORCiD, Florian SchlagenhaufORCiDGND, Michael N. SmolkaORCiDGND, Andreas HeinzORCiDGND |
---|
URN: | urn:nbn:de:kobv:517-opus4-473280 |
---|
DOI: | https://doi.org/10.25932/publishup-47328 |
---|
ISSN: | 1866-8364 |
---|
Title of parent work (English): | Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe |
---|
Subtitle (English): | Behavioral, Neural and Polygenic Correlates |
---|
Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe (841) |
---|
Publication type: | Postprint |
---|
Language: | English |
---|
Date of first publication: | 2019/08/08 |
---|
Publication year: | 2019 |
---|
Publishing institution: | Universität Potsdam |
---|
Release date: | 2023/07/14 |
---|
Tag: | Pavlovian-to-instrumental transfer; alcohol; amygdala; high risk drinkers; polygenic risk |
---|
Issue: | 841 |
---|
Number of pages: | 14 |
---|
Source: | Journal of Clinical Medicine 8 (2019) 8 DOI: 10.3390/jcm8081188 |
---|
Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Sport- und Gesundheitswissenschaften |
---|
DDC classification: | 1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie |
---|
Peer review: | Referiert |
---|
Publishing method: | Open Access / Green Open-Access |
---|
License (German): | CC-BY - Namensnennung 4.0 International |
---|
External remark: | Bibliographieeintrag der Originalveröffentlichung/Quelle |
---|