Model-based Confirmation of Alternative Substrates of Mitochondrial Electron Transport Chain
- Background: There are alternative substrates to the mitochondrial respiration. Results: Data-driven model-based analysis renders predictions of alternative substrates to the mitochondrial respiration. Conclusion: Metabolomics data in conjunction with flux-based models can discriminate among hypotheses based on enzymology alone. Significance: This analysis provides a basic framework for in silico studies of alternative pathways in metabolism.
Author details: | Sabrina Kleessen, Wagner L. Araujo, Alisdair FernieORCiDGND, Zoran NikoloskiORCiDGND |
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DOI: | https://doi.org/10.1074/jbc.M111.310383 |
ISSN: | 0021-9258 |
Title of parent work (English): | The journal of biological chemistry |
Publisher: | American Society for Biochemistry and Molecular Biology |
Place of publishing: | Bethesda |
Publication type: | Article |
Language: | English |
Year of first publication: | 2012 |
Publication year: | 2012 |
Release date: | 2017/03/26 |
Volume: | 287 |
Issue: | 14 |
Number of pages: | 10 |
First page: | 11122 |
Last Page: | 11131 |
Funding institution: | Max-Planck Society; German Ministry of Science and Education [0313924] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
Peer review: | Referiert |