Thiol-Thioester exchange reactions in precursors enable pH-triggered hydrogel formation
- Bio-interactive hydrogel formation in situ requires sensory capabilities toward physiologically relevant stimuli. Here, we report on pH-controlled in situ hydrogel formation relying on latent cross-linkers, which transform from pH sensors to reactive molecules. In particular, thiopeptolide/thio-depsipeptides were capable of pH-sensitive thiol-thioester exchange reactions to yield a,co-dithiols, which react with maleimide-functionalized multi-arm polyethylene glycol to polymer networks. Their water solubility and diffusibility qualify thiol/thioester-containing peptide mimetics as sensory precursors to drive in situ localized hydrogel formation with potential applications in tissue regeneration such as treatment of inflamed tissues of the urinary tract.
| Author details: | Makafui Yao FolikumahORCiD, Marc BehlORCiDGND, Andreas LendleinORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1021/acs.biomac.0c01690 |
| ISSN: | 1525-7797 |
| ISSN: | 1526-4602 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/33724816 |
| Title of parent work (English): | Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences |
| Publisher: | American Chemical Society |
| Place of publishing: | Washington |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2021/03/16 |
| Publication year: | 2021 |
| Release date: | 2023/11/30 |
| Volume: | 22 |
| Issue: | 5 |
| Number of pages: | 10 |
| First page: | 1875 |
| Last Page: | 1884 |
| Funding institution: | Helmholtz AssociationHelmholtz Association; Helmholtz Association through Helmholtz Graduate School of Macromolecular Bioscience (MacroBio) [VH-GS-503] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Peer review: | Referiert |
| Publishing method: | Open Access / Hybrid Open-Access |
