Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem
- A one-pot tandem enzyme reaction using galactose oxidase M3-5 and aldehyde oxidase PaoABC was used to convert hydroxymethylfurfural (HMF) to the pure bioplastics precursor FDCA in 74% isolated yield. A range of alcohols was also converted to carboxylic acids in high yield under mild conditions.
| Author details: | Shane M. McKenna, Silke LeimkühlerORCiDGND, Susanne Herter, Nicholas J. Turner, Andrew J. Carnell |
|---|---|
| DOI: | https://doi.org/10.1039/c5gc00707k |
| ISSN: | 1463-9262 |
| ISSN: | 1463-9270 |
| Title of parent work (English): | Green chemistry : an international journal and green chemistry resource |
| Publisher: | Royal Society of Chemistry |
| Place of publishing: | Cambridge |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2015 |
| Publication year: | 2015 |
| Release date: | 2017/03/27 |
| Volume: | 17 |
| Issue: | 6 |
| Number of pages: | 5 |
| First page: | 3271 |
| Last Page: | 3275 |
| Funding institution: | Engineering and Physical Sciences Research Council (EPSRC); Innovative Medicines Initiative [115360]; Royal Society Wolfson Merit Award |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer review: | Referiert |
