Thiol-Thioester exchange reactions in precursors enable pH-triggered hydrogel formation
- Bio-interactive hydrogel formation in situ requires sensory capabilities toward physiologically relevant stimuli. Here, we report on pH-controlled in situ hydrogel formation relying on latent cross-linkers, which transform from pH sensors to reactive molecules. In particular, thiopeptolide/thio-depsipeptides were capable of pH-sensitive thiol-thioester exchange reactions to yield a,co-dithiols, which react with maleimide-functionalized multi-arm polyethylene glycol to polymer networks. Their water solubility and diffusibility qualify thiol/thioester-containing peptide mimetics as sensory precursors to drive in situ localized hydrogel formation with potential applications in tissue regeneration such as treatment of inflamed tissues of the urinary tract.
Author details: | Makafui Yao FolikumahORCiD, Marc BehlORCiDGND, Andreas LendleinORCiDGND |
---|---|
DOI: | https://doi.org/10.1021/acs.biomac.0c01690 |
ISSN: | 1525-7797 |
ISSN: | 1526-4602 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/33724816 |
Title of parent work (English): | Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences |
Publisher: | American Chemical Society |
Place of publishing: | Washington |
Publication type: | Article |
Language: | English |
Date of first publication: | 2021/03/16 |
Publication year: | 2021 |
Release date: | 2023/11/30 |
Volume: | 22 |
Issue: | 5 |
Number of pages: | 10 |
First page: | 1875 |
Last Page: | 1884 |
Funding institution: | Helmholtz AssociationHelmholtz Association; Helmholtz Association through Helmholtz Graduate School of Macromolecular Bioscience (MacroBio) [VH-GS-503] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer review: | Referiert |
Publishing method: | Open Access / Hybrid Open-Access |