570 Biowissenschaften; Biologie
Refine
Year of publication
- 2017 (235) (remove)
Document Type
- Article (127)
- Doctoral Thesis (46)
- Postprint (44)
- Other (8)
- Review (7)
- Habilitation Thesis (2)
- Part of a Book (1)
Is part of the Bibliography
- yes (235)
Keywords
- ancient DNA (4)
- phylogeny (4)
- Cyanobacteria (3)
- Myodes glareolus (3)
- Southeast Asia (3)
- biogeography (3)
- body height (3)
- community effect (3)
- oxidative stress (3)
- phylogeography (3)
Institute
- Institut für Biochemie und Biologie (196)
- Mathematisch-Naturwissenschaftliche Fakultät (18)
- Institut für Ernährungswissenschaft (16)
- Institut für Chemie (2)
- Department Sport- und Gesundheitswissenschaften (1)
- Extern (1)
- Institut für Geowissenschaften (1)
- Institut für Mathematik (1)
- Institut für Physik und Astronomie (1)
- Strukturbereich Kognitionswissenschaften (1)
Leukotriene B4 as an inflammatory mediator is an important biomarker for different respiratory diseases like asthma, chronic obstructive pulmonary disease or cystic lung fibrosis. Therefore the detection of LTB4 is helpful in the diagnosis of these pulmonary diseases. However, until now its determination in exhaled breath condensates suffers from problems of accuracy. Reasons for that could be improper sample collection and preparation methods of condensates and the lack of consistently assay specificity and reproducibility of the used immunoassay detection system. In this study we describe the development and the characterization of a specific monoclonal antibody (S27BC6) against LTB4, its use as molecular recognition element for the development of an enzyme-linked immunoassay to detect LTB4 and discuss possible future diagnostic applications.