570 Biowissenschaften; Biologie
Refine
Has Fulltext
- no (81)
Document Type
- Article (81) (remove)
Is part of the Bibliography
- yes (81)
Keywords
- FGF21 (3)
- acid sphingomyelinase (3)
- ceramide (3)
- inflammation (3)
- Insulin resistance (2)
- Mitochondria (2)
- Oxidative stress (2)
- Pregnancy (2)
- cancer (2)
- fatty acid metabolism (2)
- genes (2)
- insulin (2)
- lipid metabolism (2)
- liver (2)
- mitochondria (2)
- proteasome (2)
- sphingolipids (2)
- α-amylase/trypsin inhibitors (2)
- 1-Methoxy-3-indolylmethyl glucosinolate (1)
- 1-aminodecylidene bis-phosphonic acid (1)
- 1-phosphate (1)
- 20S (1)
- 2D-LC-MS/MS (1)
- 7 macrophages (1)
- Adipocytes (1)
- Adipose tissue (1)
- Adult height (1)
- Advanced glycation endproducts (1)
- Aflatoxin B1 (1)
- African indigenous vegetables (1)
- Amaranth (1)
- Amaranthaceae (1)
- Arsenic-containing fatty acids (1)
- Arsenic-containing hydrocarbons (1)
- Arsenolipids (1)
- Aspergillus (1)
- Astrocytes (1)
- Autotaxin (1)
- BBsome (1)
- Bbs4 (1)
- Beryllium (1)
- Biomarker (1)
- Blood pressure (1)
- Blood protein adducts (1)
- Boron exposure (1)
- Brassica (1)
- Brassica rapa ssp. chinensis (1)
- C-reactive protein (1)
- C. elegans (1)
- CRISPR editing validation (1)
- Caco-2 intestinal barrier model (1)
- Caco-2/HT-29-MTX-model (1)
- Caenorhabditis elegans (1)
- Cancer prevention (1)
- Cardiovascular diseases (1)
- Carotenoid (1)
- Carotenoids (1)
- Cellular uptake (1)
- Cereals (1)
- Circadian rhythm (1)
- Complications in diabetes (1)
- Copper (1)
- DNA adducts (1)
- DNA damage (1)
- DNA damage response (1)
- DNMT inhibitor (1)
- Dendritic cells (1)
- Diabetes incidence (1)
- Drug delivery (1)
- EBI3 (1)
- Eicosanoid (1)
- Energy expenditure (1)
- Et-1 (1)
- Excretion (1)
- First trimester (1)
- Flavonoid (1)
- GCN2 (1)
- GDF15 (1)
- Glucosinolate breakdown product (1)
- Glycation (1)
- HPLC/HR-ESMS (1)
- HPLC/ICPMS (1)
- HRMS (1)
- Heat shock protein 90 (1)
- Heme (1)
- Hepatic insulin resistance (1)
- Hepatocytes (1)
- High resolution microscopy (1)
- Hormones (1)
- Hyperglycaemia (1)
- Hypertension (1)
- In vitro blood-brain barrier model (1)
- Insulin signaling (1)
- Intraperitoneal administration (1)
- Isoprostane (1)
- Jurkat cells (1)
- LC-MS/MS (1)
- LC–MS/MS (1)
- LEDs (1)
- LPA(3) receptor subtype (1)
- Labile zinc (1)
- Leg length (1)
- Light quality (1)
- Liver fat (1)
- Low birth weight (1)
- Lysophosphatidic acid (1)
- MALDI-TOF-MS (1)
- MMF (1)
- MSCs (1)
- Macrovascular (1)
- Marker (1)
- Mendelian randomization (1)
- Meta-analysis (1)
- Microvascular complications (1)
- Modified mycotoxins (1)
- Multi-method (1)
- Mycotoxins (1)
- Myoglobin (1)
- NF-kappa B (1)
- NMR-based metabolomics (1)
- NZO (1)
- Nanoparticles (1)
- Neoglucobrassicin (1)
- Nutrition (1)
- OCFA (1)
- Obesity (1)
- Ontogeny (1)
- Oxylipin (1)
- Pak choi (1)
- Parkinson disease (1)
- Paternal exposure (1)
- Personalised medicine (1)
- Pesticides (1)
- PlGF (1)
- Precision medicine (1)
- Precision prognostics (1)
- Proteasome (1)
- Protein aggregates (1)
- Protein oxidation (1)
- Protein restriction (1)
- QTL (1)
- RAW 264 (1)
- RBP4 (1)
- ROS (1)
- Rats (1)
- Redox control (1)
- Retinol (1)
- Review (1)
- Risk (1)
- Risk prediction (1)
- S-XRF (1)
- SDS-PAGE (1)
- SIMS techniques (1)
- ST-1893 (1)
- ST-1894 (1)
- Se-methylselenoneine (1)
- Sex ratio at birth (1)
- Short stature (1)
- Skeletal muscle cells (1)
- Skin penetration (1)
- Small for gestational age (1)
- Smpd1 (1)
- Sphingolipids (1)
- TEM (1)
- TGF-beta (1)
- TNF alpha (1)
- TTR (1)
- Tenebrio molitor larvae (1)
- Testicle (1)
- Thermal processing (1)
- Toxicity (1)
- Trace elements (1)
- Trans-epoxy-fatty acid (1)
- Trunk length (1)
- Type 2 diabetes (1)
- Ulcerative colitis (1)
- Vitamin A (1)
- WAT (1)
- Warburg effect (1)
- World Cancer Research Fund/American Institute for Cancer Research Recommendations (1)
- Y:X chromosome ratio (1)
- Zinc (1)
- Zinc homeostasis (1)
- acid ceramidase (1)
- activated carbon (1)
- adiponectin (1)
- adipose tissue (1)
- adiposity (1)
- age (1)
- ageing (1)
- aging (1)
- all-cause mortality (1)
- amaranth (1)
- amino acids (1)
- and nutrition (1)
- anorexia (1)
- anthropometric measures (1)
- antioxidative capacity (1)
- anxiety-like behavior (1)
- apoptosis (1)
- appetite regulation (1)
- aroma quality (1)
- arsenolipids (1)
- asymmetric dimethylarginine (ADMA) (1)
- autophagy (1)
- base excision repair (incision activity) (1)
- beta-carotene hydroxylase (1)
- beta-cell (1)
- bioavailability (1)
- biofortification (1)
- biomarkers of renal failure (1)
- birth weight (1)
- bisphosphonates (1)
- blood banking (1)
- brain insulin signaling (1)
- browning (1)
- caffeic acid derivatives (1)
- calcination (1)
- cancer epidemiology (1)
- cardiokine (1)
- cardiovascular diseases (1)
- carotenoid biosynthesis (1)
- carotenoids (1)
- cellular bioimaging (1)
- cerami-des (1)
- ceramides (1)
- cereal meals (1)
- cholesterol (1)
- chronic diseases (1)
- cilium (1)
- circadian clock (1)
- clusterin (1)
- coffee by-products (1)
- colorectal neoplasm (1)
- colour (1)
- complications (1)
- constitutive androstane receptor (1)
- contrast-induced nephropathy (1)
- copper (1)
- copper-related disorders (1)
- copy number analyses (1)
- cortisol (1)
- cytokine (1)
- cytokines (1)
- database (1)
- decitabine (1)
- depressive-like behavior (1)
- design of experiment (1)
- diabetes (1)
- diabetes mellitus (1)
- diet (1)
- diet quality (1)
- dietary patterns (1)
- dietary restriction (1)
- digestive enzymes quantification (1)
- disease (1)
- drug delivery (1)
- eating disorder symptoms (1)
- electrochemistry (1)
- enzyme induction (1)
- enzymology (1)
- epidemiology (1)
- exercise (1)
- experimental antigen-induced encephalomyelitis (1)
- fatty pancreas (1)
- feeding (1)
- fermentation (1)
- fetal origins hypothesis (1)
- food (1)
- food frequency questionnaire (1)
- food group consumption (1)
- forebrain (1)
- fractionation (1)
- functional inhibitors of acid sphin-gomyelinase (1)
- functional properties (1)
- gallbladder cancer (1)
- glucocorticoid receptor (1)
- goblet cells (1)
- growth behavior (1)
- growth restriction (1)
- gwas (1)
- heart (1)
- homeostasis (1)
- homologous recombination deficiency (1)
- homology-directed repair (1)
- human excised skin (1)
- human liver microsomes (1)
- human milk (1)
- immune-inflammatory biomarkers (1)
- immunology (1)
- immunomodulator (1)
- in vitro intestinal model (1)
- infection (1)
- inhibitory cytokines (1)
- insect proteins (1)
- interleukin-35 (1)
- interleukin-8 (1)
- intestinal mucins (1)
- intestinal zinc resorption (1)
- ion-exchange chromatography (1)
- ionophore antibiotics (1)
- large population (1)
- later health (1)
- leucine (1)
- lineage commitment (1)
- lipids (1)
- liver toxicity (1)
- loci (1)
- locus of control (1)
- lung inflammation (1)
- lymphopenia (1)
- lysosomal hydrolases (1)
- lysosome (1)
- lysozyme (1)
- lysozyme activity (1)
- macrophages (1)
- maintenance of genomic integrity (1)
- manganese (1)
- mass index (1)
- mass spectrometry (1)
- mastery (1)
- meal timing (1)
- mealworm (1)
- melatonin (1)
- membrane fusion (1)
- methyl jasmonate (1)
- miRNAs (1)
- microcomputed tomography (1)
- micronutrients (1)
- microparticle (1)
- mitochondria, (1)
- mixtures (1)
- molecular pathways (1)
- morpholino analogues of fingolimod (1)
- mucus layer (1)
- multiple sclerosis (1)
- muscle (1)
- muscle fibre composition (1)
- myokine (1)
- myopathy (1)
- nanogels (1)
- native American ancestry (1)
- neurodegenerative diseases (1)
- nutrient transport (1)
- organic compounds adsorption (1)
- ovarian cancer (1)
- overweight (1)
- oxidative stress (1)
- parchment (1)
- patterns (1)
- phagocytosis (1)
- plasma (1)
- plasma measurements (1)
- platelets (1)
- poly(ADP-ribosyl)ation (1)
- polyphenols (1)
- population-specific risk marker (1)
- prediction (1)
- pregnancy (1)
- pregnane X-receptor (1)
- presystemic metabolism (1)
- proliferation (1)
- prostaglandin E2 (1)
- protein restriction (1)
- proteostasis (1)
- provitamin A (1)
- purification (1)
- rat (1)
- red wine (1)
- reliability (1)
- repeated measures design (1)
- repetitive elements (1)
- reproducibility (1)
- resistin (1)
- reversed-phase chromatography (1)
- risk (1)
- risk factors (1)
- sFlt-1 (1)
- salinomycin (1)
- saliva (1)
- salmon fish (1)
- sarcopenia (1)
- scores (1)
- selenoneine (1)
- serine palmitoyltransferase (1)
- sex (1)
- size (1)
- skin penetration (1)
- snacking (1)
- spent coffee grounds (1)
- sphingolipid de novo synthesis (1)
- sphingomyelin (1)
- sphingosine (1)
- sphingosine kinase-1 (1)
- stable-isotope labeling (1)
- storage (1)
- suPAR (1)
- tacrolimus formulation (1)
- targeted metabolomics (1)
- tea processing (1)
- tocopherols (1)
- total phenol content (1)
- transcriptomics (1)
- transformation product (1)
- transfusion-related acute lung injury (1)
- triazole fungicides (1)
- type 2 (1)
- ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) (1)
- validity (1)
- valine (1)
- valorization (1)
- variants (1)
- visfatin (1)
- volatile compounds (1)
- weight status (1)
- wheat (1)
- zinc (1)
- zinc binding (1)
Institute
- Institut für Ernährungswissenschaft (81) (remove)
The use of silver nanoparticles in medical and consumer products such as wound dressings, clothing and cosmetic has increased significantly in recent years. Still, the influence of these particles on our health and especially on our brain, has not been examined adequately up to now. We studied the influence of AgEO- (Ethylene Oxide) and AgCitrate-Nanoparticles (NPs) on the protective barriers of the brain, namely the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (blood-CSF) barrier in vitro. The NPs toxicity was evaluated by examining changes in membrane integrity, cell morphology, barrier properties, oxidative stress and inflammatory reactions. AgNPs decreased cell viability, disturbed barrier integrity and tight junctions and triggered oxidative stress and DNA strand breaks. However, all mentioned effects were, at least partly, suppressed by a Citrate-coating and were most pronounced in the cells of the BBB as compared to the epithelial cells representing the blood-CSF barrier. AgEO- but not AgCitrate-NPs also triggered an inflammatory reaction in porcine brain capillary endothelial cells (PBCEC), which represent the BBB.
Our data indicate that AgNPs may cause adverse effects within the barriers of the brain, but their toxicity can be reduced by choosing an appropriate coating material.