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To asymptotic complete scattering systems {M(+) + V, M(+)} on H(+) := L(2)(R(+), K, d lambda), where M(+) is the multiplication operator on H(+) and V is a trace class operator with analyticity conditions, a decay semigroup is associated such that the spectrum of the generator of this semigroup coincides with the set of all resonances (poles of the analytic continuation of the scattering matrix into the lower half plane across the positive half line), i.e. the decay semigroup yields a "time-dependent" characterization of the resonances. As a counterpart a "spectral characterization" is mentioned which is due to the "eigenvalue-like" properties of resonances.
Actin-based directional motility is important for embryonic development, wound healing, immune responses, and development of tissues. Actin and myosin are essential players in this process that can be subdivided into protrusion, adhesion, and traction. Protrusion is the forward movement of the membrane at the leading edge of the cell. Adhesion is required to enable movement along a substrate, and traction finally leads to the forward movement of the entire cell body, including its organelles. While actin polymerization is the main driving force in cell protrusions, myosin motors lead to the contraction of the cell body. The goal of this work was to study the regulatory mechanisms of the motile machinery by selecting a representative key player for each stage of the signaling process: the regulation of Arp2/3 activity by WASP (actin system), the role of cGMP in myosin II assembly (myosin system), and the influence of phosphoinositide signaling (upstream receptor pathway). The model organism chosen for this work was the social ameba Dictyostelium discoideum, due to the well-established knowledge of its cytoskeletal machinery, the easy handling, and the high motility of its vegetative and starvation developed cells. First, I focused on the dynamics of the actin cytoskeleton by modulating the activity of one of its key players, the Arp2/3 complex. This was achieved using the carbazole derivative Wiskostatin, an inhibitor of the Arp2/3 activator WASP. Cells treated with Wiskostatin adopted a round shape, with no of few pseudopodia. With the help of a microfluidic cell squeezer device, I could show that Wiskostatin treated cells display a reduced mechanical stability, comparable to cells treated with the actin disrupting agent Latrunculin A. Furthermore, the WASP inhibited cells adhere stronger to a surface and show a reduced motility and chemotactic performance. However, the overall F-actin content in the cells was not changed. Confocal microscopy and TIRF microscopy imaging showed that the cells maintained an intact actin cortex. Localized dynamic patches of increased actin polymerization were observed that, however, did not lead to membrane deformation. This indicated that the mechanisms of actin-driven force generation were impaired in Wiskostatin treated cells. It is concluded that in these cells, an altered architecture of the cortical network leads to a reduced overall stiffness of the cell, which is insufficient to support the force generation required for membrane deformation and pseudopod formation. Second, the role of cGMP in myosin II dynamics was investigated. Cyclic GMP is known to regulate the association of myosin II with the cytoskeleton. In Dictyostelium, intracellular cGMP levels increase when cells are exposed to chemoattractants, but also in response to osmotic stress. To study the influence of cyclic GMP on actin and myosin II dynamics, I used the laser-induced photoactivation of a DMACM-caged-Br-cGMP to locally release cGMP inside the cell. My results show that cGMP directly activates the myosin II machinery, but is also able to induce an actin response independently of cAMP receptor activation and signaling. The actin response was observed in both vegetative and developed cells. Possible explanations include cGMP-induced actin polymerization through VASP (vasodilator-stimulated phosphoprotein) or through binding of cGMP to cyclic nucleotide-dependent kinases. Finally, I investigated the role of phosphoinositide signaling using the Polyphosphoinositide-Binding Peptide (PBP10) that binds preferentially to PIP2. Phosphoinositides can recruit actin-binding proteins to defined subcellular sites and alter their activity. Neutrophils, as well as developed Dictyostelium cells produce PIP3 in the plasma membrane at their leading edge in response to an external chemotactic gradient. Although not essential for chemotaxis, phosphoinositides are proposed to act as an internal compass in the cell. When treated with the peptide PBP10, cells became round, with fewer or no pseudopods. PH-CRAC translocation to the membrane still occurs, even at low cAMP stimuli, but cell motility (random and directional) was reduced. My data revealed that the decrease in the pool of available PIP2 in the cell is sufficient to impair cell motility, but enough PIP2 remains so that PIP3 is formed in response to chemoattractant stimuli. My data thus highlights how sensitive cell motility and morphology are to changes in the phosphoinositide signaling. In summary, I have analyzed representative regulatory mechanisms that govern key parts of the motile machinery and characterized their impact on cellular properties including mechanical stability, adhesion and chemotaxis.
New materials for polymer organic light-emitting diodes based on a polymer matrix doped with phosphorescent dyes are presented. The matrix system is based on a polystyrene backbone bearing either electron or hole transporting units at the 4-position of each repeat unit. Random copolymers and polymer blend systems of the homopolymers are prepared, both with 62 wt.% electron transporting and 38 wt.% hole transporting moieties. Adding a green electrophosphorescent dye to the polymer matrix leads to efficient electroluminescence with a maximum current efficiency of 35 cd/A and a maximum external quantum efficiency of up to 10%. The mobilities of electrons and holes in the dye-doped copolymer, as measured by transient electroluminescence, are around 5 x 10(-5) and 5 x 10(-6) cm(2)/Vs, respectively, while the blend of the two homopolymers exhibits slightly lower mobilities of both types of carriers. Despite the pronounced imbalance of charge transport, the device performance is almost entirely limited by the phosphorescence efficiency of the dye, implying balanced flow of holes and electrons into the active region. Also, devices made with either the copolymer or the blend yielded very similar device efficiencies, despite the noticeable difference in electron and hole mobility. It is proposed that electrons are efficiently blocked at the interlayer and that the so-formed space charge assists the balanced injection of holes.
Corvino, Corvino and Schoen, Chruściel and Delay have shown the existence of a large class of asymptotically flat vacuum initial data for Einstein's field equations which are static or stationary in a neighborhood of space-like infinity, yet quite general in the interior. The proof relies on some abstract, non-constructive arguments which makes it difficult to calculate such data numerically by using similar arguments. A quasilinear elliptic system of equations is presented of which we expect that it can be used to construct vacuum initial data which are asymptotically flat, time-reflection symmetric, and asymptotic to static data up to a prescribed order at space-like infinity. A perturbation argument is used to show the existence of solutions. It is valid when the order at which the solutions approach staticity is restricted to a certain range. Difficulties appear when trying to improve this result to show the existence of solutions that are asymptotically static at higher order. The problems arise from the lack of surjectivity of a certain operator. Some tensor decompositions in asymptotically flat manifolds exhibit some of the difficulties encountered above. The Helmholtz decomposition, which plays a role in the preparation of initial data for the Maxwell equations, is discussed as a model problem. A method to circumvent the difficulties that arise when fast decay rates are required is discussed. This is done in a way that opens the possibility to perform numerical computations. The insights from the analysis of the Helmholtz decomposition are applied to the York decomposition, which is related to that part of the quasilinear system which gives rise to the difficulties. For this decomposition analogous results are obtained. It turns out, however, that in this case the presence of symmetries of the underlying metric leads to certain complications. The question, whether the results obtained so far can be used again to show by a perturbation argument the existence of vacuum initial data which approach static solutions at infinity at any given order, thus remains open. The answer requires further analysis and perhaps new methods.
Arhammar, C. ; Pietzsch, Annette ; Bock, Nicolas ; Holmstroem, Erik ; Araujo, C. Moyses ; Grasjo, Johan ; Zhao, Shuxi ; Green, Sara ; Peery, T. ; Hennies, Franz ; Amerioun, Shahrad ; Föhlisch, Alexander ; Schlappa, Justine ; Schmitt, Thorsten ; Strocov, Vladimir N. ; Niklasson, Gunnar A. ; Wallace, Duane C. ; Rubensson, Jan-Erik ; Johansson, Borje ; Ahuja, Rajeev C.
Amorphous materials represent a large and important emerging area of material's science. Amorphous oxides are key technological oxides in applications such as a gate dielectric in Complementary metal-oxide semiconductor devices and in Silicon-Oxide-Nitride-Oxide-Silicon and TANOS (TaN-Al2O3-Si3N4-SiO2-Silicon) flash memories. These technologies are required for the high packing density of today's integrated circuits. Therefore the investigation of defect states in these structures is crucial. In this work we present X-ray synchrotron measurements, with an energy resolution which is about 5-10 times higher than is attainable with standard spectrometers, of amorphous alumina. We demonstrate that our experimental results are in agreement with calculated spectra of amorphous alumina which we have generated by stochastic quenching. This first principles method, which we have recently developed, is found to be superior to molecular dynamics in simulating the rapid gas to solid transition that takes place as this material is deposited for thin film applications. We detect and analyze in detail states in the band gap that originate from oxygen pairs. Similar states were previously found in amorphous alumina by other spectroscopic methods and were assigned to oxygen vacancies claimed to act mutually as electron and hole traps. The oxygen pairs which we probe in this work act as hole traps only and will influence the information retention in electronic devices. In amorphous silica oxygen pairs have already been found, thus they may be a feature which is characteristic also of other amorphous metal oxides.
Aliu, E. ; Aune, T. ; Beilicke, M. ; Benbow, W. ; Boettcher, Markus ; Bouvier, A. ; Bradbury, S. M. ; Buckley, J. H. ; Bugaev, V. ; Cannon, A. ; Cesarini, A. ; Ciupik, L. ; Connolly, M. P. ; Cui, W. ; Decerprit, G. ; Dickherber, R. ; Duke, C. ; Errando, M. ; Falcone, A. ; Feng, Q. ; Finnegan, G. ; Fortson, L. ; Furniss, A. ; Galante, N. ; Gall, D. ; Gillanders, G. H. ; Godambe, S. ; Griffin, S. ; Grube, J. ; Gyuk, G. ; Hanna, D. ; Hivick, B. ; Holder, J. ; Huan, H. ; Hughes, G. ; Hui, C. M. ; Humensky, T. B. ; Kaaret, P. ; Karlsson, N. ; Kertzman, M. ; Kieda, D. ; Krawczynski, H. ; Krennrich, F. ; Maier, G. ; Majumdar, P. ; McArthur, S. ; McCann, A. ; Moriarty, P. ; Mukherjee, R. ; Nelson, T. ; Ong, R. A. ; Orr, M. ; Otte, A. N. ; Park, N. ; Perkins, J. S. ; Pichel, A. ; Pohl, Martin ; Prokoph, H. ; Quinn, J. ; Ragan, K. ; Reyes, L. C. ; Reynolds, P. T. ; Roache, E. ; Rose, H. J. ; Ruppel, J. ; Saxon, D. B. ; Sembroski, G. H. ; Skole, C. ; Smith, A. W. ; Staszak, D. ; Tesic, G. ; Theiling, M. ; Thibadeau, S. ; Tsurusaki, K. ; Tyler, J. ; Varlotta, A. ; Vassiliev, V. V. ; Wakely, S. P. ; Weekes, T. C. ; Weinstein, A. ; Williams, D. A. ; Zitzer, B. ; Ciprini, S. ; Fumagalli, M. ; Kaplan, K. ; Paneque, D. ; Prochaska, J. X.
We report on the VERITAS discovery of very high energy (VHE) gamma-ray emission above 200 GeV from the high-frequency-peaked BL Lac (HBL) object RX J0648.7+1516 (GB J0648+1516), associated with 1FGL J0648.8+1516. The photon spectrum above 200 GeV is fitted by a power law dN/dE = F-0(E/E-0)(-Gamma) with a photon index Gamma of 4.4 +/- 0.8(stat) +/- 0.3(syst) and a flux normalization F-0 of (2.3 +/- 0.5(stat) +/- 1.2(sys)) x 10(-11) TeV-1 cm(-2) s(-1) with E-0 = 300 GeV. No VHE variability is detected during VERITAS observations of RX J0648.7+1516 between 2010 March 4 and April 15. Following the VHE discovery, the optical identification and spectroscopic redshift were obtained using the Shane 3 m Telescope at the Lick Observatory, showing the unidentified object to be a BL Lac type with a redshift of z = 0.179. Broadband multiwavelength observations contemporaneous with the VERITAS exposure period can be used to subclassify the blazar as an HBL object, including data from the MDM observatory, Swift-UVOT, and X-Ray Telescope, and continuous monitoring at photon energies above 1 GeV from the Fermi Large Area Telescope (LAT). We find that in the absence of undetected, high-energy rapid variability, the one-zone synchrotron self-Compton (SSC) model overproduces the high-energy gamma-ray emission measured by the Fermi-LAT over 2.3 years. The spectral energy distribution can be parameterized satisfactorily with an external-Compton or lepto-hadronic model, which have two and six additional free parameters, respectively, compared to the one-zone SSC model.
Aliu, E. ; Arlen, T. ; Aune, T. ; Beilicke, M. ; Benbow, W. ; Bouvier, A. ; Bradbury, S. M. ; Buckley, J. H. ; Bugaev, V. ; Byrum, K. ; Cannon, A. ; Cesarini, A. ; Christiansen, J. L. ; Ciupik, L. ; Collins-Hughes, E. ; Connolly, M. P. ; Cui, W. ; Dickherber, R. ; Duke, C. ; Errando, M. ; Falcone, A. ; Finley, J. P. ; Finnegan, G. ; Fortson, L. ; Furniss, A. ; Galante, N. ; Gall, D. ; Gibbs, K. ; Gillanders, G. H. ; Godambe, S. ; Griffin, S. ; Grube, J. ; Guenette, R. ; Gyuk, G. ; Hanna, D. ; Holder, J. ; Huan, H. ; Hughes, G. ; Hui, C. M. ; Humensky, T. B. ; Imran, A. ; Kaaret, P. ; Karlsson, N. ; Kertzman, M. ; Kieda, D. ; Krawczynski, H. ; Krennrich, F. ; Lang, M. J. ; Lyutikov, M. ; Madhavan, A. S. ; Maier, G. ; Majumdar, P. ; McArthur, S. ; McCann, A. ; McCutcheon, M. ; Moriarty, P. ; Mukherjee, R. ; Nunez, P. ; Ong, R. A. ; Orr, M. ; Otte, A. N. ; Park, N. ; Perkins, J. S. ; Pizlo, F. ; Pohl, Martin ; Prokoph, H. ; Quinn, J. ; Ragan, K. ; Reyes, L. C. ; Reynolds, P. T. ; Roache, E. ; Rose, H. J. ; Ruppel, J. ; Saxon, D. B. ; Schroedter, M. ; Sembroski, G. H. ; Sentuerk, G. D. ; Smith, A. W. ; Staszak, D. ; Tesic, G. ; Theiling, M. ; Thibadeau, S. ; Tsurusaki, K. ; Tyler, J. ; Varlotta, A. ; Vassiliev, V. V. ; Vincent, S. ; Vivier, M. ; Wakely, S. P. ; Ward, J. E. ; Weekes, T. C. ; Weinstein, A. ; Weisgarber, T. ; Williams, D. A. ; Zitzer, B.
We report the detection of pulsed gamma rays from the Crab pulsar at energies above 100 giga-electron volts (GeV) with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) array of atmospheric Cherenkov telescopes. The detection cannot be explained on the basis of current pulsar models. The photon spectrum of pulsed emission between 100 mega-electron volts and 400 GeV is described by a broken power law that is statistically preferred over a power law with an exponential cutoff. It is unlikely that the observation can be explained by invoking curvature radiation as the origin of the observed gamma rays above 100 GeV. Our findings require that these gamma rays be produced more than 10 stellar radii from the neutron star.
Aliu, E. ; Arlen, T. ; Aune, T. ; Beilicke, M. ; Benbow, W. ; Boettcher, Markus ; Bouvier, A. ; Bradbury, S. M. ; Buckley, J. H. ; Bugaev, V. ; Cannon, A. ; Cesarini, A. ; Ciupik, L. ; Collins-Hughes, E. ; Connolly, M. P. ; Cui, W. ; Dickherber, R. ; Errando, M. ; Falcone, A. ; Finley, J. P. ; Fortson, L. ; Furniss, A. ; Galante, N. ; Gall, D. ; Gillanders, G. H. ; Godambe, S. ; Griffin, S. ; Grube, J. ; Gyuk, G. ; Hanna, D. ; Holder, J. ; Huan, H. ; Hughes, G. ; Hui, C. M. ; Humensky, T. B. ; Kaaret, P. ; Karlsson, N. ; Kertzman, M. ; Kieda, D. ; Krawczynski, H. ; Krennrich, F. ; Madhavan, A. S. ; Maier, G. ; Majumdar, P. ; McArthur, S. ; McCann, A. ; Moriarty, P. ; Mukherjee, R. ; Ong, R. A. ; Orr, M. ; Otte, A. N. ; Park, N. ; Perkins, J. S. ; Pichel, A. ; Pohl, Martin ; Prokoph, H. ; Quinn, J. ; Ragan, K. ; Reyes, L. C. ; Reynolds, P. T. ; Roache, E. ; Rose, H. J. ; Ruppel, J. ; Saxon, D. B. ; Schroedter, M. ; Sembroski, G. H. ; Skole, C. ; Smith, A. W. ; Staszak, D. ; Tesic, G. ; Theiling, M. ; Thibadeau, S. ; Tsurusaki, K. ; Tyler, J. ; Varlotta, A. ; Vincent, S. ; Vivier, M. ; Wakely, S. P. ; Ward, J. E. ; Weinstein, A. ; Weisgarber, T. ; Williams, D. A.
We report on very high energy (>100 GeV) gamma-ray observations of Swift J164449.3+573451, an unusual transient object first detected by the Swift Observatory and later detected by multiple radio, optical, and X-ray observatories. A total exposure of 28 hr was obtained on Swift J164449.3+573451 with the Very Energetic Radiation Imaging Telescope Array System ( VERITAS) during 2011 March 28-April 15. We do not detect the source and place a differential upper limit on the emission at 500 GeV during these observations of 1.4 x 10(-12) erg cm(-2) s(-1) (99% confidence level). We also present time-resolved upper limits and use a flux limit averaged over the X-ray flaring period to constrain various emission scenarios that can accommodate both the radio-through-X-ray emission detected from the source and the lack of detection by VERITAS.
Actis, M. ; Agnetta, G. ; Aharonian, Felix A. ; Akhperjanian, A. G. ; Aleksic, J. ; Aliu, E. ; Allan, D. ; Allekotte, I. ; Antico, F. ; Antonelli, L. A. ; Antoranz, P. ; Aravantinos, A. ; Arlen, T. ; Arnaldi, H. ; Artmann, S. ; Asano, K. ; Asorey, H. G. ; Baehr, J. ; Bais, A. ; Baixeras, C. ; Bajtlik, S. ; Balis, D. ; Bamba, A. ; Barbier, C. ; Barcelo, M. ; Barnacka, Anna ; Barnstedt, Jürgen ; de Almeida, U. Barres ; Barrio, J. A. ; Basso, S. ; Bastieri, D. ; Bauer, C. ; Becerra Gonzalez, J. ; Becherini, Yvonne ; Bechtol, K. C. ; Becker, J. ; Beckmann, Volker ; Bednarek, W. ; Behera, B. ; Beilicke, M. ; Belluso, M. ; Benallou, M. ; Benbow, W. ; Berdugo, J. ; Berger, K. ; Bernardino, T. ; Bernlöhr, K. ; Biland, A. ; Billotta, S. ; Bird, T. ; Birsin, E. ; Bissaldi, E. ; Blake, S. ; Blanch Bigas, O. ; Bobkov, A. 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Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.
Ackermann, Margit ; Ajello, M. ; Allafort, A. J. ; Baldini, L. ; Ballet, J. ; Barbiellini, G. ; Bastieri, D. ; Belfiore, A. ; Bellazzini, R. ; Berenji, B. ; Blandford, R. D. ; Bloom, E. D. ; Bonamente, E. ; Borgland, A. W. ; Bottacini, E. ; Brigida, M. ; Bruel, P. ; Buehler, R. ; Buson, S. ; Caliandro, G. A. ; Cameron, R. A. ; Caraveo, P. A. ; Casandjian, J. M. ; Cecchi, C. ; Chekhtman, A. ; Cheung, C. C. ; Chiang, J. ; Ciprini, S. ; Claus, R. ; Cohen-Tanugi, J. ; de Angelis, A. ; de Palma, F. ; Dermer, C. D. ; do Couto e Silva, E. ; Drell, P. S. ; Dumora, D. ; Favuzzi, C. ; Fegan, S. J. ; Focke, W. B. ; Fortin, P. ; Fukazawa, Y. ; Fusco, P. ; Gargano, F. ; Germani, S. ; Giglietto, N. ; Giordano, F. ; Giroletti, M. ; Glanzman, T. ; Godfrey, G. ; Grenier, I. A. ; Guillemot, L. ; Guiriec, S. ; Hadasch, D. ; Hanabata, Y. ; Harding, A. K. ; Hayashida, M. ; Hayashi, K. ; Hays, E. ; Johannesson, G. ; Johnson, A. S. ; Kamae, T. ; Katagiri, H. ; Kataoka, J. ; Kerr, M. ; Knoedlseder, J. ; Kuss, M. ; Lande, J. ; Latronico, L. ; Lee, S. -H. ; Longo, F. ; Loparco, F. ; Lott, B. ; Lovellette, M. N. ; Lubrano, P. ; Martin, P. ; Mazziotta, Mario Nicola ; McEnery, J. E. ; Mehault, J. ; Michelson, P. F. ; Mitthumsiri, W. ; Mizuno, T. ; Monte, C. ; Monzani, M. E. ; Morselli, A. ; Moskalenko, I. V. ; Murgia, S. ; Naumann-Godo, M. ; Nolan, P. L. ; Norris, J. P. ; Nuss, E. ; Ohsugi, T. ; Okumura, A. ; Orlando, E. ; Ormes, J. F. ; Ozaki, M. ; Paneque, D. ; Parent, D. ; Pesce-Rollins, M. ; Pierbattista, M. ; Piron, F. ; Pohl, Martin ; Prokhorov, D. ; Raino, S. ; Rando, R. ; Razzano, M. ; Reposeur, T. ; Ritz, S. ; Parkinson, P. M. Saz ; Sgro, C. ; Siskind, E. J. ; Smith, P. D. ; Spinelli, P. ; Strong, A. W. ; Takahashi, H. ; Tanaka, T. ; Thayer, J. G. ; Thayer, J. B. ; Thompson, D. J. ; Tibaldo, L. ; Torres, D. F. ; Tosti, G. ; Tramacere, A. ; Troja, E. ; Uchiyama, Y. ; Vandenbroucke, J. ; Vasileiou, V. ; Vianello, G. ; Vitale, V. ; Waite, A. P. ; Wang, P. ; Winer, B. L. ; Wood, K. S. ; Yang, Z. ; Zimmer, S. ; Bontemps, S.
The origin of Galactic cosmic rays is a century-long puzzle. Indirect evidence points to their acceleration by supernova shockwaves, but we know little of their escape from the shock and their evolution through the turbulent medium surrounding massive stars. Gamma rays can probe their spreading through the ambient gas and radiation fields. The Fermi Large Area Telescope (LAT) has observed the star-forming region of Cygnus X. The 1- to 100-gigaelectronvolt images reveal a 50-parsec-wide cocoon of freshly accelerated cosmic rays that flood the cavities carved by the stellar winds and ionization fronts from young stellar clusters. It provides an example to study the youth of cosmic rays in a superbubble environment before they merge into the older Galactic population.