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Most information systems log events (e.g., transaction logs, audit traits) to audit and monitor the processes they support. At the same time, many of these processes have been explicitly modeled. For example, SAP R/3 logs events in transaction logs and there are EPCs (Event-driven Process Chains) describing the so-called reference models. These reference models describe how the system should be used. The coexistence of event logs and process models raises an interesting question: "Does the event log conform to the process model and vice versa?". This paper demonstrates that there is not a simple answer to this question. To tackle the problem, we distinguish two dimensions of conformance: fitness (the event log may be the result of the process modeled) and appropriateness (the model is a likely candidate from a structural and behavioral point of view). Different metrics have been defined and a Conformance Checker has been implemented within the ProM Framework
The emergence of drug resistance remains one of the most challenging issues in the treatment of HIV-1 infection. The extreme replication dynamics of HIV facilitates its escape from the selective pressure exerted by the human immune system and by the applied combination drug therapy. This article reviews computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genotypic and phenotypic data. Genotypic assays are based on the analysis of mutations associated with reduced drug susceptibility, but are difficult to interpret due to the numerous mutations and mutational patterns that confer drug resistance. Phenotypic resistance or susceptibility can be experimentally evaluated by measuring the inhibition of the viral replication in cell culture assays. However, this procedure is expensive and time consuming