Institut für Informatik und Computational Science
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Institute
Computational methods for the design of effective therapies against drug resistant HIV strains
(2005)
The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data
It is proved that the number of components in context-free cooperating distributed (CD) grammar systems can be reduced to 3 when they are working in the so-called sf-mode of derivation, which is the cooperation protocol which has been considered first for CD grammar systems. In this derivation mode, a component continues the derivation until and unless there is a nonterminal in the sentential form which cannot be rewritten according to that component. Moreover, it is shown that CD grammar systems in sf-mode with only one component can generate only the context-free languages but they can generate non-context-free languages if two components are used. The sf-mode of derivation is compared with other well-known cooperation protocols with respect to the hierarchies induced by the number of components. (C) 2004 Elsevier B.V. All rights reserved
We investigate the operation problem for linear and deterministic context-free languages: Fix an operation on formal languages. Given linear (deterministic, respectively) context-free languages, is the application of this operation to the given languages still a linear (deterministic, respectively) context-free language? Besides the classical operations, for which the linear and deterministic context-free languages are not closed, we also consider the recently introduced root and power operation. We show non-semidecidability, to be more precise, we show completeness for the second level of the arithmetic hierarchy for all of the aforementioned operations, except for the power operation, if the underlying alphabet contains at least two letters. The result for the power opera, tion solves an open problem stated in Theoret. Comput. Sci. 314 (2004) 445-449
E-Government requires technical and organizational innovation. Research has already shown that the respective innovation process is complex and contingent upon specific organizational structures. Managing such innovation processes successfully is difficult. Drawing on assumptions of micropolitical behavior, a framework of innovation arenas is proposed. It supports the analysis of ongoing E-Government projects as well as the ex post investigation of successful or failed projects. Testing this framework in case studies already demonstrates its usefulness for individual actors making strategic choices about change management. Furthermore, the results indicate that many commonly held assumptions about successful change management have to be reconsidered
We study a novel representation of semiautomata, which is motivated by the method of trace-assertion specifications of software modules. Each state of the semiautomaton is represented by an arbitrary word leading to that state, the canonical word. The transitions of the semiautomaton give rise to a right congruence, the state-equivalence, on the set of input words of the semiautomaton: two words are state-equivalent if and only if they lead to the same state. We present a simple algorithm for finding a set of generators for state-equivalence. Directly from this set of generators, we construct a confluent prefix-rewriting system which permits us to transform any word to its canonical representative. In general, the rewriting system may allow infinite derivations. To address this issue, we impose the condition of prefix-continuity on the set of canonical words. A set is prefix-continuous if, whenever a word w and a prefix u of w axe in the set, then all the prefixes of w longer than u are also in the set. Prefix-continuous sets include prefix-free and prefix-closed sets as special cases. We prove that the rewriting system is Noetherian if and only if the set of canonical words is prefix-continuous. Furthermore, if the set of canonical words is prefix- continuous, then the set of rewriting rules is irredundant. We show that each prefix-continuous canonical set corresponds to a spanning forest of the semiautomaton
Grundlagen digitaler Systeme
(2005)
In this paper we prove Chaitin's "heuristic principle," the theorems of a finitely-specified theory cannot be significantly more complex than the theory itself, for an appropriate measure of complexity. We show that the measure is invariant under the change of the Godel numbering. For this measure, the theorems of a finitely-specified, sound, consistent theory strong enough to formalize arithmetic which is arithmetically sound (like Zermelo-Fraenkel set theory with choice or Peano Arithmetic) have bounded complexity, hence every sentence of the theory which is significantly more complex than the theory is unprovable. Previous results showing that incompleteness is not accidental, but ubiquitous are here reinforced in probabilistic terms: the probability that a true sentence of length n is provable in the theory tends to zero when n tends to infinity, while the probability that a sentence of length n is true is strictly positive. (c) 2004 Elsevier Inc. All rights reserved
Reiter's default logic is one of the best known and most studied of the approaches to nonmonotonic reasoning. Several variants of default logic have subsequently been proposed to give systems with properties differing from the original. In this paper, we examine the relationship between default logic and its major variants. We accomplish this by translating a default theory under a variant interpretation into a second default theory, under the original Reiter semantics, wherein the variant interpretation is respected. That is, in each case we show that, given an extension of a translated theory, one may extract an extension of the original variant default logic theory. We show how constrained, rational, justified, and cumulative default logic can be expressed in Reiter's default logic. As well, we show how Reiter's default logic can be expressed in rational default logic. From this, we suggest that any such variant can be similarly treated. Consequently, we provide a unification of default logics, showing how the original formulation of default logic may express its variants. Moreover, the translations clearly express the relationships between alternative approaches to default logic. The translations themselves are shown to generally have good properties. Thus, in at least a theoretical sense, we show that these variants are in a sense superfluous, in that for any of these variants of default logic, we can exactly mimic the behaviour of a variant in standard default logic. As well, the translations lend insight into means of classifying the expressive power of default logic variants; specifically we suggest that the property of semi-monotonicity represents a division with respect to expressibility, whereas regularity and cumulativity do not
Geovisualization offers powerful tools, techniques, and strategies to present, explore, analyze, and manage geoinformation. Interactive geovirtual environments such as virtual 3D maps or virtual 3D city models, however, raise the question how to control geodata usage and distribution. We present a concept for embedding digital rights in geovisualizations. It is based on geo-documents, an object-oriented scheme to specify a wide range of geo visualizations. Geo-documents are assembled by building blocks categorized into presentation, structure, interaction, animation, and Digital Rights Management (DRM) classes. DRM objects allow for defining permissions and constraints for all objects contained in geo-documents. In this way, authors of geo visualizations can control how their geo-documents are used, personalized, and redistributed by users. The strengths of the presented concept include the ability to integrate heterogeneous 2D and 3D geodata within a compact design scheme and the ability to cope with privacy, security, and copyright issues. Embedded digital rights in geovisualizations can be applied to improve the usability of geodata user interfaces, to implement publisher-subscriber communication systems for geodata, and to establish business models for geodata trading systems
Modern biological analysis techniques supply scientists with various forms of data. One category of such data are the so called "expression data". These data indicate the quantities of biochemical compounds present in tissue samples. Recently, expression data can be generated at a high speed. This leads in turn to amounts of data no longer analysable by classical statistical techniques. Systems biology is the new field that focuses on the modelling of this information. At present, various methods are used for this purpose. One superordinate class of these methods is machine learning. Methods of this kind had, until recently, predominantly been used for classification and prediction tasks. This neglected a powerful secondary benefit: the ability to induce interpretable models. Obtaining such models from data has become a key issue within Systems biology. Numerous approaches have been proposed and intensively discussed. This thesis focuses on the examination and exploitation of one basic technique: decision trees. The concept of comparing sets of decision trees is developed. This method offers the possibility of identifying significant thresholds in continuous or discrete valued attributes through their corresponding set of decision trees. Finding significant thresholds in attributes is a means of identifying states in living organisms. Knowing about states is an invaluable clue to the understanding of dynamic processes in organisms. Applied to metabolite concentration data, the proposed method was able to identify states which were not found with conventional techniques for threshold extraction. A second approach exploits the structure of sets of decision trees for the discovery of combinatorial dependencies between attributes. Previous work on this issue has focused either on expensive computational methods or the interpretation of single decision trees a very limited exploitation of the data. This has led to incomplete or unstable results. That is why a new method is developed that uses sets of decision trees to overcome these limitations. Both the introduced methods are available as software tools. They can be applied consecutively or separately. That way they make up a package of analytical tools that usefully supplement existing methods. By means of these tools, the newly introduced methods were able to confirm existing knowledge and to suggest interesting and new relationships between metabolites.
Today, InfiniBand is an evolving high speed interconnect technology to build high performance computing clusters, that achieve top 10 rankings in the current top 500 of the worldwide fastest supercomputers. Network interfaces (called host channel adapters) provide transport layer services over connections and datagrams in reliable or unreliable manner. Additionally, InfiniBand supports remote direct memory access (RDMA) primitives that allow for one- sided communication. Using server load balancing together with a high performance cluster makes it possible to build a fast, scalable, and reliable service infrastructure. We have designed and implemented a scalable load balancer for InfiniBand clusters called SLIBNet. Our investigations show that the InfiniBand architecture offers features which perfectly support load balancing. We want to thank the Megware Computer GmbH for providing us an InfiniBand switch to realize a server load balancing testbed.
Quantified Boolean formulas (QBFs) play an important role in theoretical computer science. QBF extends propositional logic in such a way that many advanced forms of reasoning can be easily formulated and evaluated. In this dissertation we present our ZQSAT, which is an algorithm for evaluating quantified Boolean formulas. ZQSAT is based on ZBDD: Zero-Suppressed Binary Decision Diagram , which is a variant of BDD, and an adopted version of the DPLL algorithm. It has been implemented in C using the CUDD: Colorado University Decision Diagram package. The capability of ZBDDs in storing sets of subsets efficiently enabled us to store the clauses of a QBF very compactly and let us to embed the notion of memoization to the DPLL algorithm. These points led us to implement the search algorithm in such a way that we could store and reuse the results of all previously solved subformulas with a little overheads. ZQSAT can solve some sets of standard QBF benchmark problems (known to be hard for DPLL based algorithms) faster than the best existing solvers. In addition to prenex-CNF, ZQSAT accepts prenex-NNF formulas. We show and prove how this capability can be exponentially beneficial.