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Background
More than in other domains the heterogeneous services world in bioinformatics demands for a methodology to classify and relate resources in a both human and machine accessible manner. The Semantic Web, which is meant to address exactly this challenge, is currently one of the most ambitious projects in computer science. Collective efforts within the community have already led to a basis of standards for semantic service descriptions and meta-information. In combination with process synthesis and planning methods, such knowledge about types and services can facilitate the automatic composition of workflows for particular research questions.
Results
In this study we apply the synthesis methodology that is available in the Bio-jETI workflow management framework for the semantics-based composition of EMBOSS services. EMBOSS (European Molecular Biology Open Software Suite) is a collection of 350 tools (March 2010) for various sequence analysis tasks, and thus a rich source of services and types that imply comprehensive domain models for planning and synthesis approaches. We use and compare two different setups of our EMBOSS synthesis domain: 1) a manually defined domain setup where an intuitive, high-level, semantically meaningful nomenclature is applied to describe the input/output behavior of the single EMBOSS tools and their classifications, and 2) a domain setup where this information has been automatically derived from the EMBOSS Ajax Command Definition (ACD) files and the EMBRACE Data and Methods ontology (EDAM). Our experiments demonstrate that these domain models in combination with our synthesis methodology greatly simplify working with the large, heterogeneous, and hence manually intractable EMBOSS collection. However, they also show that with the information that can be derived from the (current) ACD files and EDAM ontology alone, some essential connections between services can not be recognized.
Conclusions
Our results show that adequate domain modeling requires to incorporate as much domain knowledge as possible, far beyond the mere technical aspects of the different types and services. Finding or defining semantically appropriate service and type descriptions is a difficult task, but the bioinformatics community appears to be on the right track towards a Life Science Semantic Web, which will eventually allow automatic service composition methods to unfold their full potential.
Bio-jETI
(2008)
Background: With Bio-jETI, we introduce a service platform for interdisciplinary work on biological application domains and illustrate its use in a concrete application concerning statistical data processing in R and xcms for an LC/MS analysis of FAAH gene knockout.
Methods: Bio-jETI uses the jABC environment for service-oriented modeling and design as a graphical process modeling tool and the jETI service integration technology for remote tool execution.
Conclusions: As a service definition and provisioning platform, Bio-jETI has the potential to become a core technology in interdisciplinary service orchestration and technology transfer. Domain experts, like biologists not trained in computer science, directly define complex service orchestrations as process models and use efficient and complex bioinformatics tools in a simple and intuitive way.
We present an approach that provides automatic or semi-automatic support for evolution and change management in heterogeneous legacy landscapes where (1) legacy heterogeneous, possibly distributed platforms are integrated in a service oriented fashion, (2) the coordination of functionality is provided at the service level, through orchestration, (3) compliance and correctness are provided through policies and business rules, (4) evolution and correctness-by-design are supported by the eXtreme Model Driven Development paradigm (XMDD) offered by the jABC (Margaria and Steffen in Annu. Rev. Commun. 57, 2004)—the model-driven service oriented development platform we use here for integration, design, evolution, and governance. The artifacts are here semantically enriched, so that automatic synthesis plugins can field the vision of Enterprise Physics: knowledge driven business process development for the end user.
We demonstrate this vision along a concrete case study that became over the past three years a benchmark for Semantic Web Service discovery and mediation. We enhance the Mediation Scenario of the Semantic Web Service Challenge along the 2 central evolution paradigms that occur in practice: (a) Platform migration: platform substitution of a legacy system by an ERP system and (b) Backend extension: extension of the legacy Customer Relationship Management (CRM) and Order Management System (OMS) backends via an additional ERP layer.
Denken in Services ist der Schlüssel zu einer gemeinsamen Sicht für IT Experten, Business Experten und Manager auf bestehende und entstehende Anwendungen und damit zu einer engeren Zusammenarbeit, die heutige Arbeitsabläufe revolutionieren kann: Auf der Service-Ebene ist es erstmals möglich, Fachexperten kontinuierlich während des gesamten Lebens-zyklus einer Anwendung einzubinden. Ihren Ursprung hat die service- orientierte Denkweise in der Telekommunikation, wo sie die Grundlage der modernsten Anwendungen für mobile und feste Plattformen war, insbesondere der so genannten Mehrwertdienste, wie Televoting, Freephone (die 0800 Nummern), Virtual Private Network. Nur durch die für die service-orientierung charakteristische konsequente Virtualisierung der Infrastrukturen und die lose Kopplung der Funktionalitäten war es möglich, die hochgradig heterogene Landschaft der Telefonie zu beherrschen. Dieselben Prinzipien sind aber viel allgemeiner anwendbar, zum Beispiel auch für Dienste in weniger technischen Geschäftsbereichen wie e-commerce, Logistik, Gesundheitswesen oder Verwaltung. Ihre konsequente Umsetzung als neues Paradigma für die Konzeption, den Entwurf und das Management komplexer Anwendungen hat das Potential, der Gesellschaft eine neue Generation personalisierter, sicherer, hochverfügbarer und effizienter (Internet-) Dienstleistungen zu bescheren. Damit werden viele Geschäftsbereiche revolutioniert, ähnlich wie bereits die Email in vielen Bereichen die klassische Kommunikation per Post revolutioniert hat.
Simplicity is a mindset, a way of looking at solutions, an extremely wide-ranging philosophical stance on the world, and thus a deeply rooted cultural paradigm. The culture of "less" can be profoundly disruptive, cutting out existing "standard" elements from products and business models, thereby revolutionizing entire markets.
Existing telecommunication networks and classical roles of operators are subject to fundamental change. Many network operators are currently seeking for new sources to generate revenue by exposing network capabilities to 3rd party service providers. At the same time we can observe that services on the World Wide Web (WWW) are becoming mature in terms of the definition of APIs that are offered towards other services. The combinations of those services are commonly referred to as Web 2.0 mash-ups. Rapid service design and creation becomes therefore important to meet the requirements in a changing technology and competitive market environment. This report describes our approach to include Next Generation Networks (NGN)-based telecommunications application enabler into complex services by defining a service broker that mediates between 3rd party applications and NGN service enablers. It provides policy-driven orchestration mechanisms for service enablers, a service authorization functionality, and a service discovery interface for Service Creation Environments. The work has been implemented as part of the Open SOA Telco Playground testbed at Fraunhofer FOKUS.