Refine
Has Fulltext
- no (4) (remove)
Author
- Boomsma, Dorret I. (4)
- Dedoussis, George V. (4)
- Grant, Struan F. A. (4)
- Hakonarson, Hakon (4)
- Hocher, Berthold (4)
- Hofman, Albert (4)
- Holloway, John W. (4)
- Horikoshi, Momoko (4)
- Jaddoe, Vincent W. V. (4)
- Jarvelin, Marjo-Riitta (4)
- Ntalla, Ioanna (4)
- Pennell, Craig E. (4)
- Raitakari, Olli T. (4)
- Rivadeneira, Fernando (4)
- Saw, Seang-Mei (4)
- Sebert, Sylvain (4)
- Smith, George Davey (4)
- Timpson, Nicholas J. (4)
- Uitterlinden, Andre G. (4)
- van Duijn, Cornelia M. (4)
- Adair, Linda S. (3)
- Ang, Wei (3)
- Atalay, Mustafa (3)
- Barton, Sheila J. (3)
- Bisgaard, Hans (3)
- Bonnelykke, Klaus (3)
- Bradfield, Jonathan P. (3)
- Bustamante, Mariona (3)
- Cousminer, Diana L. (3)
- Estivill, Xavier (3)
- Evans, David M. (3)
- Feenstra, Bjarke (3)
- Flexeder, Claudia (3)
- Frayling, Timothy M. (3)
- Freathy, Rachel M. (3)
- Geller, Frank (3)
- Heinrich, Joachim (3)
- Hirschhorn, Joel N. (3)
- Huikari, Ville (3)
- Kiess, Wieland (3)
- Koerner, Antje (3)
- Lakka, Timo A. (3)
- Lawlor, Debbie A. (3)
- Lindi, Virpi (3)
- Mahajan, Anubha (3)
- McCarthy, Mark I. (3)
- Melbye, Mads (3)
- Mohlke, Karen L. (3)
- Mook-Kanamori, Dennis O. (3)
- Niinikoski, Harri (3)
- Ong, Ken K. (3)
- Panoutsopoulou, Kalliope (3)
- Ring, Susan M. (3)
- St Pourcain, Beate (3)
- Taal, H. Rob (3)
- Teo, Yik-Ying (3)
- Thiering, Elisabeth (3)
- Willemsen, Gonneke (3)
- Wilson, James F. (3)
- Zeggini, Eleftheria (3)
- Bennett, Amanda J. (2)
- Berry, Diane J. (2)
- Blakemore, Alexandra I. F. (2)
- Buxton, Jessica L. (2)
- Cooper, Cyrus (2)
- Das, Shikta (2)
- Eriksson, Johan G. (2)
- Goh, Liang-Kee (2)
- Groen-Blokhuis, Maria (2)
- Guxens, Monica (2)
- Hansen, Torben (2)
- Hartikainen, Anna-Liisa (2)
- Hattersley, Andrew T. (2)
- Hayes, M. Geoffrey (2)
- Heikkinen, Jani (2)
- Hottenga, Jouke-Jan (2)
- Hougaard, David M. (2)
- Hypponen, Elina (2)
- Inskip, Hazel M. (2)
- Jacobsson, Bo (2)
- Joro, Raimo (2)
- Kaakinen, Marika (2)
- Kemp, John P. (2)
- Kerkhof, Marjan (2)
- Kilpelainen, Tuomas O. (2)
- Kirin, Mirna (2)
- Knight, Bridget A. (2)
- Kooijman, Marjolein N. (2)
- Koppelman, Gerard H. (2)
- Kreiner-Moller, Eskil (2)
- Lagou, Vasiliki (2)
- Lehtimaki, Terho (2)
- Lowe, William L. (2)
- Medina-Gomez, Carolina (2)
- Mentch, Frank D. (2)
- Murray, Jeffrey C. (2)
- Myhre, Ronny (2)
- Newnham, John P. (2)
- Pahkala, Katja (2)
- Pearson, Ewan R. (2)
- Pedersen, Oluf (2)
- Postma, Dirkje S. (2)
- Power, Chris (2)
- Prokopenko, Inga (2)
- Robertson, Neil R. (2)
- Rodriguez, Alina (2)
- Salem, Rany M. (2)
- Shields, Beverley M. (2)
- Simell, Olli (2)
- Sorensen, Thorkild I. A. (2)
- Sovio, Ulla (2)
- Stokholm, Jakob (2)
- Stumvoll, Michael (2)
- Tiesler, Carla M. T. (2)
- Viikari, Jorma S. (2)
- Vollenweider, Peter (2)
- Wareham, Nicholas J. (2)
- Warrington, Nicole M. (2)
- Widen, Elisabeth (2)
- Wu, Ying (2)
- Yaghootkar, Hanieh (2)
- Zhao, Jing Hua (2)
- van Leeuwen, Elisabeth M. (2)
- Ahluwalia, Tarunveer Singh (1)
- Al-Odaib, Ali (1)
- Alkuraya, Fowzan S. (1)
- Allard, Catherine (1)
- Alves, Alexessander Da Silva Couto (1)
- Amouyel, Philippe (1)
- Andersson, Ehm Astrid (1)
- Appel, Emil V. R. (1)
- Armstrong, Loren L. (1)
- Au, Rhoda (1)
- Bacelis, Jonas (1)
- Bartels, Meike (1)
- Beaumont, Robin (1)
- Beilin, Lawrence J. (1)
- Beiser, Alexa (1)
- Benke, Kelly (1)
- Bergen, Nienke (1)
- Bergstrom, Anna (1)
- Bonàs-Guarch, Sílvia (1)
- Boreham, Colin A. G. (1)
- Borja, Judith B. (1)
- Bouchard, Luigi (1)
- Breteler, Monique M. B. (1)
- Campbell, Harry (1)
- Catellier, Diane (1)
- Cavadino, Alana (1)
- Chai, Jin-Fang (1)
- Charoen, Pimphen (1)
- Chatzi, Leda (1)
- Chawes, Bo L. (1)
- Chawes, Bo Lund Krogsgaard (1)
- Chen, Jia (1)
- Coin, Lachlan (1)
- Coker, Laura H. (1)
- Curtin, John A. (1)
- Custovic, Adnan (1)
- Dallongeville, Jean (1)
- Davis, Oliver S. P. (1)
- Day, Felix R. (1)
- DeCarli, Charles (1)
- DeStefano, Anita L. (1)
- Debette, Stephanie (1)
- Elliott, Paul (1)
- Eloranta, Aino-Maija (1)
- Eriksen, Patrick (1)
- Eriksson, Johan (1)
- Espinosa, Ana (1)
- Felix, Janine F. (1)
- Fernandez-Tajes, Juan (1)
- Fonvig, Cilius Esmann (1)
- Fornage, Myriam (1)
- Franke, Lude (1)
- Frayling, Tim (1)
- Froguel, Philippe (1)
- Fulford, Anthony J. (1)
- Gaillard, Romy (1)
- Gaulton, Kyle J. (1)
- Gehring, Ulrike (1)
- Gillman, Matthew (1)
- Gillman, Matthew W. (1)
- Godfrey, Keith M. (1)
- Gonzalez, Juan R. (1)
- Gottrand, Frederic (1)
- Grallert, Harald (1)
- Grarup, Niels (1)
- Groves, Christopher J. (1)
- Gudnason, Haukur (1)
- Gudnason, Vilmundur (1)
- Hadley, Dexter (1)
- Hao, Ke (1)
- Harder, Marie N. (1)
- Harris, Tamara B. (1)
- Have, Christian Theil (1)
- Haworth, Claire M. A. (1)
- Hebebrand, Johannes (1)
- Helgeland, Øyvind (1)
- Hemani, Gibran (1)
- Hennig, Branwen J. (1)
- Hinney, Anke (1)
- Hivert, Marie-France (1)
- Hollegaard, Mads V. (1)
- Holm, Jens-Christian (1)
- Holst, Claus (1)
- Hottenga, Jouke Jan (1)
- Huang, Jinyan (1)
- Hyppoenen, Elina (1)
- Ikram, M. Arfan (1)
- Ilonen, Jorma (1)
- Isaacs, Aaron (1)
- Jack, Clifford R. (1)
- Jameson, Karen A. (1)
- Johansson, Stefan (1)
- Jones, Samuel E. (1)
- Jorgensen, Torben (1)
- Joshi, Peter K. (1)
- Kadarmideen, Haja N. (1)
- Kaehoenen, Mika (1)
- Kanaka-Gantenbein, Christina (1)
- Keinanen-Kiukaanniemi, Sirkka (1)
- Klopp, Norman (1)
- Knip, Mikael (1)
- Knopman, David S. (1)
- Kogevinas, Manolis (1)
- Kovacs, Peter (1)
- Kowgier, Matthew (1)
- Kull, Inger (1)
- Kutalik, Zoltan (1)
- Kutalik, Zoltán (1)
- Kuzawa, Christopher W. (1)
- Lakka, Hanna-Maaria (1)
- Lakka, Timo (1)
- Lange, Leslie A. (1)
- Langenberg, Claudia (1)
- Launer, Lenore J. (1)
- Laurin, Charles (1)
- Lehtimaeki, Terho (1)
- Lewin, Alex (1)
- Lewin, Alexandra (1)
- Li-Gao, Ruifang (1)
- Liang, Liming (1)
- Lind, Penelope A. (1)
- Lindgren, Cecilia (1)
- Linneberg, Allan (1)
- Llop, Sabrina (1)
- Loh, Po-Ru (1)
- Longstreth, W. T. (1)
- Loos, Ruth J. F. (1)
- Lunetta, Kathryn L. (1)
- Lyytikainen, Leo-Pekka (1)
- Lyytikäinen, Leo-Pekka (1)
- Maggi, Reedik (1)
- Magnus, Per (1)
- Marques-Vidal, Pedro (1)
- Marsh, Julie (1)
- Marsh, Julie A. (1)
- Marsit, Carmen (1)
- Marullo, Letizia (1)
- Mbarek, Hamdi (1)
- McMahon, George (1)
- Mccarthy, Mark I. (1)
- Medland, Sarah Elizabeth (1)
- Meeks, William M. (1)
- Meirhaeghe, Aline (1)
- Melen, Erik (1)
- Mercader, Josep M. (1)
- Metrustry, Sarah (1)
- Meyer, Brian F. (1)
- Michaelsen, Kim Fleischer (1)
- Middeldorp, Christel (1)
- Millwood, Iona (1)
- Moen, Gunn-Helen (1)
- Monies, Dorota M. (1)
- Montgomery, Grant W. (1)
- Moreno, Luis A. (1)
- Morgen, Camilla S. (1)
- Morris, Andrew P. (1)
- Mosley, Thomas H. (1)
- Muglia, Louis J. (1)
- Murabito, Joanne M. (1)
- Murcia, Mario (1)
- Murray, Anna (1)
- Murray, Clare S. (1)
- Müller-Nurasyid, Martina (1)
- Nalls, Mike A. (1)
- Niessen, Wiro J. (1)
- Nivard, Michel (1)
- Njolstad, Pal R. (1)
- Nodzenski, Michael (1)
- Nohr, Ellen A. (1)
- Nohr, Ellen Aagaard (1)
- Oken, Emily (1)
- Oostra, Ben A. (1)
- Painter, Jodie N. (1)
- Palmer, Lyle J. (1)
- Palotie, Aarno (1)
- Pararajasingham, Jennifer (1)
- Paternoster, Lavinia (1)
- Pedersen, Louise (1)
- Peng, Shouneng (1)
- Perry, John R. B. (1)
- Pers, Tune H. (1)
- Pfab, Thiemo (1)
- Pisinger, Charlotta (1)
- Pitkanen, Niina (1)
- Pitkänen, Niina (1)
- Pouta, Anneli (1)
- Power, Christine (1)
- Prentice, Andrew M. (1)
- Price, Thomas S. (1)
- Qiao, Zhen (1)
- Rayner, N. William (1)
- Reichetzeder, Christoph (1)
- Relton, Caroline L. (1)
- Richmond, Rebecca C. (1)
- Ropele, Stefan (1)
- Rosendaal, Frits R. (1)
- Rueedi, Rico (1)
- Ruth, Katherine S. (1)
- Saaf, Annika (1)
- Saarinen, Maiju (1)
- Santa-Marina, Loreto (1)
- Scherag, Andre (1)
- Schmidt, Helena (1)
- Schmidt, Reinhold (1)
- Schnurr, Theresia M. (1)
- Scholtens, Denise M. (1)
- Schraut, Katharina E. (1)
- Scott, Robert A. (1)
- Sengpiel, Verena (1)
- Sergeyev, Elena (1)
- Seshadri, Sudha (1)
- Sevelsted, Astrid (1)
- Sigurdsson, Sigurdur (1)
- Siitonen, Niina (1)
- Simpson, Angela (1)
- Slowinski, Torsten (1)
- Smith, Albert V. (1)
- Spector, Tim D. (1)
- Standl, Marie (1)
- Steegers, Eric A. P. (1)
- Stergiakouli, Evangelia (1)
- Strachan, David P. (1)
- Struchalin, Maksim (1)
- Sunyer, Jordi (1)
- Sánchez, Friman (1)
- Thiering, Elisabeth Paula (1)
- Toenjes, Anke (1)
- Torrents, David (1)
- Trier, Caecilie (1)
- Tuke, Marcus A. (1)
- Tyrrell, Jessica (1)
- Tönjes, Anke (1)
- Vaag, Allan (1)
- Vaag, Allan A. (1)
- Vaarasmaki, Marja (1)
- Valcarcel, Beatriz (1)
- Vaudel, Marc (1)
- Veijola, Riitta (1)
- Vernooij, Meike W. (1)
- Vilor-Tejedor, Natalia (1)
- Vinding, Rebecca K. (1)
- Vink, Jacqueline M. (1)
- Vissing, Nadja Hawwa (1)
- Vrijheid, Martine (1)
- Vrijkotte, Tanja G. M. (1)
- Vrooman, Henri A. (1)
- Waage, Johannes (1)
- Wang, Carol A. (1)
- Warrington, Nicole (1)
- Weedon, Michael N. (1)
- Widen, Elisabeth E. (1)
- Willems, Sara M. (1)
- Windham, B. Gwen (1)
- Witte, Daniel R. (1)
- Wolf, Philip A. (1)
- Wood, Andrew R. (1)
- Zafarmand, Mohammad Hadi (1)
- Zhang, Ge (1)
- Zhang, Haitao (1)
- Zhao, Jianhua (1)
- Zhou, Kaixin (1)
- Zijdenbos, Alex P. (1)
- de Geus, Eco J. C. (1)
- de Geus, Eco J. C. N. (1)
- de Haan, Hugoline G. (1)
- de Jongste, Johan C. (1)
- den Hoed, Marcel (1)
- van Beijsterveldt, Catharina E. M. (1)
- van Buchem, Mark A. (1)
- van Kampen, Antoine H. C. (1)
- van Schaik, Barbera D. C. (1)
- van Zuydam, Natalie R. (1)
- van der Lugt, Aad (1)
- van der Valk, Ralf J. P. (1)
- vanBeijsterveldt, Toos (1)
Document Type
- Article (4)
Language
- English (4)
Is part of the Bibliography
- yes (4)
Institute
- Institut für Ernährungswissenschaft (4) (remove)
Warrington, Nicole ; Beaumont, Robin ; Horikoshi, Momoko ; Day, Felix R. ; Helgeland, Øyvind ; Laurin, Charles ; Bacelis, Jonas ; Peng, Shouneng ; Hao, Ke ; Feenstra, Bjarke ; Wood, Andrew R. ; Mahajan, Anubha ; Tyrrell, Jessica ; Robertson, Neil R. ; Rayner, N. William ; Qiao, Zhen ; Moen, Gunn-Helen ; Vaudel, Marc ; Marsit, Carmen ; Chen, Jia ; Nodzenski, Michael ; Schnurr, Theresia M. ; Zafarmand, Mohammad Hadi ; Bradfield, Jonathan P. ; Grarup, Niels ; Kooijman, Marjolein N. ; Li-Gao, Ruifang ; Geller, Frank ; Ahluwalia, Tarunveer Singh ; Paternoster, Lavinia ; Rueedi, Rico ; Huikari, Ville ; Hottenga, Jouke-Jan ; Lyytikäinen, Leo-Pekka ; Cavadino, Alana ; Metrustry, Sarah ; Cousminer, Diana L. ; Wu, Ying ; Thiering, Elisabeth Paula ; Wang, Carol A. ; Have, Christian Theil ; Vilor-Tejedor, Natalia ; Joshi, Peter K. ; Painter, Jodie N. ; Ntalla, Ioanna ; Myhre, Ronny ; Pitkänen, Niina ; van Leeuwen, Elisabeth M. ; Joro, Raimo ; Lagou, Vasiliki ; Richmond, Rebecca C. ; Espinosa, Ana ; Barton, Sheila J. ; Inskip, Hazel M. ; Holloway, John W. ; Santa-Marina, Loreto ; Estivill, Xavier ; Ang, Wei ; Marsh, Julie A. ; Reichetzeder, Christoph ; Marullo, Letizia ; Hocher, Berthold ; Lunetta, Kathryn L. ; Murabito, Joanne M. ; Relton, Caroline L. ; Kogevinas, Manolis ; Chatzi, Leda ; Allard, Catherine ; Bouchard, Luigi ; Hivert, Marie-France ; Zhang, Ge ; Muglia, Louis J. ; Heikkinen, Jani ; Morgen, Camilla S. ; van Kampen, Antoine H. C. ; van Schaik, Barbera D. C. ; Mentch, Frank D. ; Langenberg, Claudia ; Scott, Robert A. ; Zhao, Jing Hua ; Hemani, Gibran ; Ring, Susan M. ; Bennett, Amanda J. ; Gaulton, Kyle J. ; Fernandez-Tajes, Juan ; van Zuydam, Natalie R. ; Medina-Gomez, Carolina ; de Haan, Hugoline G. ; Rosendaal, Frits R. ; Kutalik, Zoltán ; Marques-Vidal, Pedro ; Das, Shikta ; Willemsen, Gonneke ; Mbarek, Hamdi ; Müller-Nurasyid, Martina ; Standl, Marie ; Appel, Emil V. R. ; Fonvig, Cilius Esmann ; Trier, Caecilie ; van Beijsterveldt, Catharina E. M. ; Murcia, Mario ; Bustamante, Mariona ; Bonàs-Guarch, Sílvia ; Hougaard, David M. ; Mercader, Josep M. ; Linneberg, Allan ; Schraut, Katharina E. ; Lind, Penelope A. ; Medland, Sarah Elizabeth ; Shields, Beverley M. ; Knight, Bridget A. ; Chai, Jin-Fang ; Panoutsopoulou, Kalliope ; Bartels, Meike ; Sánchez, Friman ; Stokholm, Jakob ; Torrents, David ; Vinding, Rebecca K. ; Willems, Sara M. ; Atalay, Mustafa ; Chawes, Bo L. ; Kovacs, Peter ; Prokopenko, Inga ; Tuke, Marcus A. ; Yaghootkar, Hanieh ; Ruth, Katherine S. ; Jones, Samuel E. ; Loh, Po-Ru ; Murray, Anna ; Weedon, Michael N. ; Tönjes, Anke ; Stumvoll, Michael ; Michaelsen, Kim Fleischer ; Eloranta, Aino-Maija ; Lakka, Timo A. ; van Duijn, Cornelia M. ; Kiess, Wieland ; Koerner, Antje ; Niinikoski, Harri ; Pahkala, Katja ; Raitakari, Olli T. ; Jacobsson, Bo ; Zeggini, Eleftheria ; Dedoussis, George V. ; Teo, Yik-Ying ; Saw, Seang-Mei ; Montgomery, Grant W. ; Campbell, Harry ; Wilson, James F. ; Vrijkotte, Tanja G. M. ; Vrijheid, Martine ; de Geus, Eco J. C. N. ; Hayes, M. Geoffrey ; Kadarmideen, Haja N. ; Holm, Jens-Christian ; Beilin, Lawrence J. ; Pennell, Craig E. ; Heinrich, Joachim ; Adair, Linda S. ; Borja, Judith B. ; Mohlke, Karen L. ; Eriksson, Johan G. ; Widen, Elisabeth E. ; Hattersley, Andrew T. ; Spector, Tim D. ; Kaehoenen, Mika ; Viikari, Jorma S. ; Lehtimaeki, Terho ; Boomsma, Dorret I. ; Sebert, Sylvain ; Vollenweider, Peter ; Sorensen, Thorkild I. A. ; Bisgaard, Hans ; Bonnelykke, Klaus ; Murray, Jeffrey C. ; Melbye, Mads ; Nohr, Ellen A. ; Mook-Kanamori, Dennis O. ; Rivadeneira, Fernando ; Hofman, Albert ; Felix, Janine F. ; Jaddoe, Vincent W. V. ; Hansen, Torben ; Pisinger, Charlotta ; Vaag, Allan A. ; Pedersen, Oluf ; Uitterlinden, Andre G. ; Jarvelin, Marjo-Riitta ; Power, Christine ; Hypponen, Elina ; Scholtens, Denise M. ; Lowe, William L. ; Smith, George Davey ; Timpson, Nicholas J. ; Morris, Andrew P. ; Wareham, Nicholas J. ; Hakonarson, Hakon ; Grant, Struan F. A. ; Frayling, Timothy M. ; Lawlor, Debbie A. ; Njolstad, Pal R. ; Johansson, Stefan ; Ong, Ken K. ; McCarthy, Mark I. ; Perry, John R. B. ; Evans, David M. ; Freathy, Rachel M.
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.
Horikoshi, Momoko ; Yaghootkar, Hanieh ; Mook-Kanamori, Dennis O. ; Sovio, Ulla ; Taal, H. Rob ; Hennig, Branwen J. ; Bradfield, Jonathan P. ; St Pourcain, Beate ; Evans, David M. ; Charoen, Pimphen ; Kaakinen, Marika ; Cousminer, Diana L. ; Lehtimaki, Terho ; Kreiner-Moller, Eskil ; Warrington, Nicole M. ; Bustamante, Mariona ; Feenstra, Bjarke ; Berry, Diane J. ; Thiering, Elisabeth ; Pfab, Thiemo ; Barton, Sheila J. ; Shields, Beverley M. ; Kerkhof, Marjan ; van Leeuwen, Elisabeth M. ; Fulford, Anthony J. ; Kutalik, Zoltan ; Zhao, Jing Hua ; den Hoed, Marcel ; Mahajan, Anubha ; Lindi, Virpi ; Goh, Liang-Kee ; Hottenga, Jouke-Jan ; Wu, Ying ; Raitakari, Olli T. ; Harder, Marie N. ; Meirhaeghe, Aline ; Ntalla, Ioanna ; Salem, Rany M. ; Jameson, Karen A. ; Zhou, Kaixin ; Monies, Dorota M. ; Lagou, Vasiliki ; Kirin, Mirna ; Heikkinen, Jani ; Adair, Linda S. ; Alkuraya, Fowzan S. ; Al-Odaib, Ali ; Amouyel, Philippe ; Andersson, Ehm Astrid ; Bennett, Amanda J. ; Blakemore, Alexandra I. F. ; Buxton, Jessica L. ; Dallongeville, Jean ; Das, Shikta ; de Geus, Eco J. C. ; Estivill, Xavier ; Flexeder, Claudia ; Froguel, Philippe ; Geller, Frank ; Godfrey, Keith M. ; Gottrand, Frederic ; Groves, Christopher J. ; Hansen, Torben ; Hirschhorn, Joel N. ; Hofman, Albert ; Hollegaard, Mads V. ; Hougaard, David M. ; Hyppoenen, Elina ; Inskip, Hazel M. ; Isaacs, Aaron ; Jorgensen, Torben ; Kanaka-Gantenbein, Christina ; Kemp, John P. ; Kiess, Wieland ; Kilpelainen, Tuomas O. ; Klopp, Norman ; Knight, Bridget A. ; Kuzawa, Christopher W. ; McMahon, George ; Newnham, John P. ; Niinikoski, Harri ; Oostra, Ben A. ; Pedersen, Louise ; Postma, Dirkje S. ; Ring, Susan M. ; Rivadeneira, Fernando ; Robertson, Neil R. ; Sebert, Sylvain ; Simell, Olli ; Slowinski, Torsten ; Tiesler, Carla M. T. ; Toenjes, Anke ; Vaag, Allan ; Viikari, Jorma S. ; Vink, Jacqueline M. ; Vissing, Nadja Hawwa ; Wareham, Nicholas J. ; Willemsen, Gonneke ; Witte, Daniel R. ; Zhang, Haitao ; Zhao, Jianhua ; Wilson, James F. ; Stumvoll, Michael ; Prentice, Andrew M. ; Meyer, Brian F. ; Pearson, Ewan R. ; Boreham, Colin A. G. ; Cooper, Cyrus ; Gillman, Matthew W. ; Dedoussis, George V. ; Moreno, Luis A. ; Pedersen, Oluf ; Saarinen, Maiju ; Mohlke, Karen L. ; Boomsma, Dorret I. ; Saw, Seang-Mei ; Lakka, Timo A. ; Koerner, Antje ; Loos, Ruth J. F. ; Ong, Ken K. ; Vollenweider, Peter ; van Duijn, Cornelia M. ; Koppelman, Gerard H. ; Hattersley, Andrew T. ; Holloway, John W. ; Hocher, Berthold ; Heinrich, Joachim ; Power, Chris ; Melbye, Mads ; Guxens, Monica ; Pennell, Craig E. ; Bonnelykke, Klaus ; Bisgaard, Hans ; Eriksson, Johan G. ; Widen, Elisabeth ; Hakonarson, Hakon ; Uitterlinden, Andre G. ; Pouta, Anneli ; Lawlor, Debbie A. ; Smith, George Davey ; Frayling, Timothy M. ; McCarthy, Mark I. ; Grant, Struan F. A. ; Jaddoe, Vincent W. V. ; Jarvelin, Marjo-Riitta ; Timpson, Nicholas J. ; Prokopenko, Inga ; Freathy, Rachel M.
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits(2). In an expanded genome-wide association metaanalysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Ikram, M. Arfan ; Fornage, Myriam ; Smith, Albert V. ; Seshadri, Sudha ; Schmidt, Reinhold ; Debette, Stephanie ; Vrooman, Henri A. ; Sigurdsson, Sigurdur ; Ropele, Stefan ; Taal, H. Rob ; Mook-Kanamori, Dennis O. ; Coker, Laura H. ; Longstreth, W. T. ; Niessen, Wiro J. ; DeStefano, Anita L. ; Beiser, Alexa ; Zijdenbos, Alex P. ; Struchalin, Maksim ; Jack, Clifford R. ; Rivadeneira, Fernando ; Uitterlinden, Andre G. ; Knopman, David S. ; Hartikainen, Anna-Liisa ; Pennell, Craig E. ; Thiering, Elisabeth ; Steegers, Eric A. P. ; Hakonarson, Hakon ; Heinrich, Joachim ; Palmer, Lyle J. ; Jarvelin, Marjo-Riitta ; McCarthy, Mark I. ; Grant, Struan F. A. ; St Pourcain, Beate ; Timpson, Nicholas J. ; Smith, George Davey ; Sovio, Ulla ; Nalls, Mike A. ; Au, Rhoda ; Hofman, Albert ; Gudnason, Haukur ; van der Lugt, Aad ; Harris, Tamara B. ; Meeks, William M. ; Vernooij, Meike W. ; van Buchem, Mark A. ; Catellier, Diane ; Jaddoe, Vincent W. V. ; Gudnason, Vilmundur ; Windham, B. Gwen ; Wolf, Philip A. ; van Duijn, Cornelia M. ; Mosley, Thomas H. ; Schmidt, Helena ; Launer, Lenore J. ; Breteler, Monique M. B. ; DeCarli, Charles ; Adair, Linda S. ; Ang, Wei ; Atalay, Mustafa ; vanBeijsterveldt, Toos ; Bergen, Nienke ; Benke, Kelly ; Berry, Diane J. ; Coin, Lachlan ; Davis, Oliver S. P. ; Elliott, Paul ; Flexeder, Claudia ; Frayling, Tim ; Gaillard, Romy ; Groen-Blokhuis, Maria ; Goh, Liang-Kee ; Haworth, Claire M. A. ; Hadley, Dexter ; Hebebrand, Johannes ; Hinney, Anke ; Hirschhorn, Joel N. ; Holloway, John W. ; Holst, Claus ; Hottenga, Jouke Jan ; Horikoshi, Momoko ; Huikari, Ville ; Hypponen, Elina ; Kilpelainen, Tuomas O. ; Kirin, Mirna ; Kowgier, Matthew ; Lakka, Hanna-Maaria ; Lange, Leslie A. ; Lawlor, Debbie A. ; Lehtimaki, Terho ; Lewin, Alex ; Lindgren, Cecilia ; Lindi, Virpi ; Maggi, Reedik ; Marsh, Julie ; Middeldorp, Christel ; Millwood, Iona ; Murray, Jeffrey C. ; Nivard, Michel ; Nohr, Ellen Aagaard ; Ntalla, Ioanna ; Oken, Emily ; Panoutsopoulou, Kalliope ; Pararajasingham, Jennifer ; Rodriguez, Alina ; Salem, Rany M. ; Sebert, Sylvain ; Siitonen, Niina ; Strachan, David P. ; Teo, Yik-Ying ; Valcarcel, Beatriz ; Willemsen, Gonneke ; Zeggini, Eleftheria ; Boomsma, Dorret I. ; Cooper, Cyrus ; Gillman, Matthew ; Hocher, Berthold ; Lakka, Timo A. ; Mohlke, Karen L. ; Dedoussis, George V. ; Ong, Ken K. ; Pearson, Ewan R. ; Price, Thomas S. ; Power, Chris ; Raitakari, Olli T. ; Saw, Seang-Mei ; Scherag, Andre ; Simell, Olli ; Sorensen, Thorkild I. A. ; Wilson, James F.
During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.
A novel common variant in DCST2 is associated with length in early life and height in adulthood
(2015)
van der Valk, Ralf J. P. ; Kreiner-Moller, Eskil ; Kooijman, Marjolein N. ; Guxens, Monica ; Stergiakouli, Evangelia ; Saaf, Annika ; Bradfield, Jonathan P. ; Geller, Frank ; Hayes, M. Geoffrey ; Cousminer, Diana L. ; Koerner, Antje ; Thiering, Elisabeth ; Curtin, John A. ; Myhre, Ronny ; Huikari, Ville ; Joro, Raimo ; Kerkhof, Marjan ; Warrington, Nicole M. ; Pitkanen, Niina ; Ntalla, Ioanna ; Horikoshi, Momoko ; Veijola, Riitta ; Freathy, Rachel M. ; Teo, Yik-Ying ; Barton, Sheila J. ; Evans, David M. ; Kemp, John P. ; St Pourcain, Beate ; Ring, Susan M. ; Smith, George Davey ; Bergstrom, Anna ; Kull, Inger ; Hakonarson, Hakon ; Mentch, Frank D. ; Bisgaard, Hans ; Chawes, Bo Lund Krogsgaard ; Stokholm, Jakob ; Waage, Johannes ; Eriksen, Patrick ; Sevelsted, Astrid ; Melbye, Mads ; van Duijn, Cornelia M. ; Medina-Gomez, Carolina ; Hofman, Albert ; de Jongste, Johan C. ; Taal, H. Rob ; Uitterlinden, Andre G. ; Armstrong, Loren L. ; Eriksson, Johan ; Palotie, Aarno ; Bustamante, Mariona ; Estivill, Xavier ; Gonzalez, Juan R. ; Llop, Sabrina ; Kiess, Wieland ; Mahajan, Anubha ; Flexeder, Claudia ; Tiesler, Carla M. T. ; Murray, Clare S. ; Simpson, Angela ; Magnus, Per ; Sengpiel, Verena ; Hartikainen, Anna-Liisa ; Keinanen-Kiukaanniemi, Sirkka ; Lewin, Alexandra ; Alves, Alexessander Da Silva Couto ; Blakemore, Alexandra I. F. ; Buxton, Jessica L. ; Kaakinen, Marika ; Rodriguez, Alina ; Sebert, Sylvain ; Vaarasmaki, Marja ; Lakka, Timo ; Lindi, Virpi ; Gehring, Ulrike ; Postma, Dirkje S. ; Ang, Wei ; Newnham, John P. ; Lyytikainen, Leo-Pekka ; Pahkala, Katja ; Raitakari, Olli T. ; Panoutsopoulou, Kalliope ; Zeggini, Eleftheria ; Boomsma, Dorret I. ; Groen-Blokhuis, Maria ; Ilonen, Jorma ; Franke, Lude ; Hirschhorn, Joel N. ; Pers, Tune H. ; Liang, Liming ; Huang, Jinyan ; Hocher, Berthold ; Knip, Mikael ; Saw, Seang-Mei ; Holloway, John W. ; Melen, Erik ; Grant, Struan F. A. ; Feenstra, Bjarke ; Lowe, William L. ; Widen, Elisabeth ; Sergeyev, Elena ; Grallert, Harald ; Custovic, Adnan ; Jacobsson, Bo ; Jarvelin, Marjo-Riitta ; Atalay, Mustafa ; Koppelman, Gerard H. ; Pennell, Craig E. ; Niinikoski, Harri ; Dedoussis, George V. ; Mccarthy, Mark I. ; Frayling, Timothy M. ; Sunyer, Jordi ; Timpson, Nicholas J. ; Rivadeneira, Fernando ; Bonnelykke, Klaus ; Jaddoe, Vincent W. V.
Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
- 1 to 4