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Institute
Inhalt:
Carolin Schulz: „Ein scharfsinniger Kopf aus Berlin!“ Ein unveröffentlichtes Empfehlungsschreiben für Leopold von Buch
- Carolina Depetris: El orientalismo como episteme: Frédéric de Waldeck y las ruinas mayas
- Ottmar Ette: Réflexions européennes sur deux phases de mondialisation accélérée chez Cornelius de Pauw, Georg Forster, Guillaume-Thomas Raynal et Alexandre de Humboldt
- Eberhard Knobloch: Nomos und physis – Alexander von Humboldt und die Tradition antiker Denkweisen und Vorstellungen
Miguel-Ángel Puig-Samper, Sandra Rebok: Charles Darwin and Alexander von Humboldt: An exchange of looks between two famous naturalists
- Georg Schifko: Jules Vernes literarische Thematisierung der Kanarischen Inseln als Hommage an Alexander v. Humboldt
- Antonio Carlos Vitte, Roberison Wittgenstein Dias de Silveira: Alexander von Humboldt y la génesis de la geografía física moderna
- Ingo Schwarz: Eine Alexander-von-Humboldt-Forscherin mit Profil: Ilse Jahn (1922-2010)
- Romy Werther, Ingo Schwarz: Ilse Jahn: Schriften zur Alexander-von-Humboldt-Forschung – Eine Auswahlbibliographie
- Ilse Jahn: Die anatomischen Studien der Brüder Humboldt unter Justus Christian Loder in Jena
Inhalt:
- Kristian Köchy: Das Ganze der Natur – Alexander von Humboldt und das romantische Forschungsprogramm
- Gerhard Kortum: „Alexander von Humboldt“ als Name für Forschungsschiffe vor dem Hintergrund seiner meereskundlichen Arbeiten
- Ulrike Leitner: „Anciennes folies neptuniennes!“ Über das wiedergefundene „Journal du Mexique à Veracruz“ aus den mexikanischen Reisetagebüchern A. v. Humboldts
- Oliver Lubrich: „Egipcios por doquier“. Alejandro de Humboldt y su visión ‘orientalista’ de América
- Jose Alberto Navas Sierra: Humboldt y el ‘Área de Libre Comercio de las Américas (ALCA)’ – Un ejercicio de ‘ciencia humboldtiana
- Miguel Ángel Puig-Samper und Sandra Rebok: Un sabio en la meseta. El viaje de Alejandro de Humboldt a España en 1799
- Ingo Schwarz: Nachruf – Zur Erinnerung an Kurt-R. Biermann
The whey protein beta-lactoglobulin has been proposed as a transporter for covalent bound bioactive compounds in order to enhance their stability and reduce their sensory perception. The garlic derived compounds allicin and diallyl disulfide were bound covalently to the native and heat denatured protein. The binding site and the influence of the modification on the digestibility were determined by mass spectrometric analysis of the modified beta-lactoglobulin. Further, the conformation of the modified protein was assessed by circular dichroism and dynamic light scattering. The free thiol group of Cys(121) turned out to be the major binding site. After proteolysis with trypsin at pH 7 but not with pepsin at pH 2, a limited transfer to other cysteinyl residues was observed. The covalently bound ligands did not mask any proteolytic cleavage sites of pepsin, trypsin or chymotrypsin. The modified beta-lactoglobulin showed a native like conformation, besides a moderate loosening of protein folding. The covalent binding of organosulfur compounds to beta-lactoglobulin provides a bioactive ingredient without impairing the digestibility and functional properties of the protein. (C) 2015 Elsevier Ltd. All rights reserved.
Following escape into the cytoplasm of host cells, Burkholderia pseudomallei and the related species Burkholderia thailandensis employ the type VI secretion system 5 ( T6SS-5) to induce plasma membrane fusion with an adjacent host cell. This process leads to the formation of multinucleated giant cells and facilitates bacterial access to an uninfected host cell in a direct manner. Despite its importance in virulence, the mechanism of the T6SS-5 and the role of host cell factors in cell-cell fusion remain elusive. To date, the T6SS-5 is the only system of bacterial origin known to induce host-cell fusion. To gain insight into the nature of T6SS-5-stimulated membrane fusion, we investigated the contribution of cholesterol and proteins exposed on the host cell surface, which were shown to be critically involved in virus-mediated giant cell formation. In particular, we analyzed the effect of host cell surface protein and cholesterol depletion on the formation of multinucleated giant cells induced by B. thailandensis. Acute protease treatment of RAW264.7 macrophages during infection with B. thailandensis followed by agarose overlay assays revealed a strong reduction in the number of cell-cell fusions compared with EDTA treated cells. Similarly, proteolytic treatment of specifically infected donor cells or uninfected recipient cells significantly decreased multinucleated giant cell formation. Furthermore, modulating host cell cholesterol content by acute cholesterol depletion from cellular membranes by methyl-beta-cyclodextrin treatment or exogenous addition of cholesterol impaired the ability of B. thailandensis to induce cell-cell fusions. The requirement of physiological cholesterol levels suggests that the membrane organization or mechanical properties of the lipid bilayer influence the fusion process. Altogether, our data suggest that membrane fusion induced by B. pseudomallei and B. thailandensis involves a complex interplay between the T6SS-5 and the host cell.
-Jill Rabea Zaun: Eduard Hildebrandts „Wunderbild“
in einem Brief von Alexander von Humboldt an Henriette Mendelssohn, geb. Meyer
-Ottmar Ette: Paris/Berlin/Havanna: Alexander von Humboldts transareale Wissenschaft und die Revolution nach der Revolution
-Frank Holl: Alexander von Humboldt und der Klimawandel
Mythen und Fakten
-Cettina Rapisarda: Antike Marmorarten nach Zoёga’s Bestimmungen. Alexander von Humboldts Sammlung und Gesteinsstudien in Rom
-Sandra Rebok: De la pintura de viaje a la fotografía: Alexander von Humboldt y la representación artística del Nuevo Mundo
-Ingo Schwarz: Der zweite Entdecker Kubas