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  • Abdo, A. A. (1)
  • Acciari, V. A. (1)
  • Ackermann, Margit (1)
  • Aich, Valentin (1)
  • Ajello, M. (1)
  • Aleksic, J. (1)
  • Allafort, A. J. (1)
  • Aller, H. D. (1)
  • Aller, M. F. (1)
  • Alves, Alexessander Da Silva Couto (1)
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  • BL Lacertae objects: general (1)
  • BL Lacertae objects: individual (Mrk 501) (1)
  • acceleration of particles (1)
  • galaxies: active (1)
  • gamma rays: general (1)
  • radiation mechanisms: non-thermal (1)

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  • Institut für Biochemie und Biologie (1)
  • Institut für Ernährungswissenschaft (1)
  • Institut für Geowissenschaften (1)
  • Institut für Physik und Astronomie (1)

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Insights into the high-energy gamma-Ray emission of markarian 501 fromextensive multifrequency observations in the fermi era (2011)
Abdo, A. A. ; Ackermann, Margit ; Ajello, M. ; Allafort, A. J. ; Baldini, L. ; Ballet, J. ; Barbiellini, G. ; Baring, M. G. ; Bastieri, D. ; Bechtol, K. C. ; Bellazzini, R. ; Berenji, B. ; Blandford, R. D. ; Bloom, E. D. ; Bonamente, E. ; Borgland, A. W. ; Bouvier, A. ; Brandt, T. J. ; Bregeon, Johan ; Brez, A. ; Brigida, M. ; Bruel, P. ; Buehler, R. ; Buson, S. ; Caliandro, G. A. ; Cameron, R. A. ; Cannon, A. ; Caraveo, P. A. ; Carrigan, Svenja ; Casandjian, J. M. ; Cavazzuti, E. ; Cecchi, C. ; Celik, O. ; Charles, E. ; Chekhtman, A. ; Cheung, C. C. ; Chiang, J. ; Ciprini, S. ; Claus, R. ; Cohen-Tanugi, J. ; Conrad, Jan ; Cutini, S. ; Dermer, C. D. ; de Palma, F. ; do Couto e Silva, E. ; Drell, P. S. ; Dubois, R. ; Dumora, D. ; Favuzzi, C. ; Fegan, S. J. ; Ferrara, E. C. ; Focke, W. B. ; Fortin, P. ; Frailis, M. ; Fuhrmann, L. ; Fukazawa, Y. ; Funk, S. ; Fusco, P. ; Gargano, F. ; Gasparrini, D. ; Gehrels, N. ; Germani, S. ; Giglietto, N. ; Giordano, F. ; Giroletti, M. ; Glanzman, T. ; Godfrey, G. ; Grenier, I. A. ; Guillemot, L. ; Guiriec, S. ; Hayashida, M. ; Hays, E. ; Horan, D. ; Hughes, R. E. ; Johannesson, G. ; Johnson, A. S. ; Johnson, W. N. ; Kadler, M. ; Kamae, T. ; Katagiri, H. ; Kataoka, J. ; Knoedlseder, J. ; Kuss, M. ; Lande, J. ; Latronico, L. ; Lee, S. -H. ; Lemoine-Goumard, M. ; Longo, F. ; Loparco, F. ; Lott, B. ; Lovellette, M. N. ; Lubrano, P. ; Madejski, G. M. ; Makeev, A. ; Max-Moerbeck, W. ; Mazziotta, M. N. ; McEnery, J. E. ; Mehault, J. ; Michelson, P. F. ; Mitthumsiri, W. ; Mizuno, T. ; Moiseev, A. A. ; Monte, C. ; Monzani, M. E. ; Morselli, A. ; Moskalenko, I. V. ; Murgia, S. ; Naumann-Godo, M. ; Nishino, S. ; Nolan, P. L. ; Norris, J. P. ; Nuss, E. ; Ohsugi, T. ; Okumura, A. ; Omodei, N. ; Orlando, E. ; Ormes, J. F. ; Paneque, D. ; Panetta, J. H. ; Parent, D. ; Pavlidou, V. ; Pearson, T. J. ; Pelassa, V. ; Pepe, M. ; Pesce-Rollins, M. ; Piron, F. ; Porter, T. A. ; Raino, S. ; Rando, R. ; Razzano, M. ; Readhead, A. ; Reimer, A. ; Reimer, O. ; Richards, J. L. ; Ripken, J. ; Ritz, S. ; Roth, M. ; Sadrozinski, H. F. -W. ; Sanchez, D. ; Sander, A. ; Scargle, J. D. ; Sgro, C. ; Siskind, E. J. ; Smith, P. D. ; Spandre, G. ; Spinelli, P. ; Stawarz, L. ; Stevenson, M. ; Strickman, M. S. ; Sokolovsky, K. V. ; Suson, D. J. ; Takahashi, H. ; Takahashi, T. ; Tanaka, T. ; Thayer, J. B. ; Thayer, J. G. ; Thompson, D. J. ; Tibaldo, L. ; Torres, F. ; Tosti, G. ; Tramacere, A. ; Uchiyama, Y. ; Usher, T. L. ; Vandenbroucke, J. ; Vasileiou, V. ; Vilchez, N. ; Vitale, V. ; Waite, A. P. ; Wang, P. ; Wehrle, A. E. ; Winer, B. L. ; Wood, K. S. ; Yang, Z. ; Ylinen, T. ; Zensus, J. A. ; Ziegler, M. ; Aleksic, J. ; Antonelli, L. A. ; Antoranz, P. ; Backes, Michael ; Barrio, J. A. ; Gonzalez, J. Becerra ; Bednarek, W. ; Berdyugin, A. ; Berger, K. ; Bernardini, E. ; Biland, A. ; Blanch Bigas, O. ; Bock, R. K. ; Boller, A. ; Bonnoli, G. ; Bordas, P. ; Tridon, D. Borla ; Bosch-Ramon, Valentin ; Bose, D. ; Braun, I. ; Bretz, T. ; Camara, M. ; Carmona, E. ; Carosi, A. ; Colin, P. ; Colombo, E. ; Contreras, J. L. ; Cortina, J. ; Covino, S. ; Dazzi, F. ; de Angelis, A. ; del Pozo, E. De Cea ; De Lotto, B. ; De Maria, M. ; De Sabata, F. ; Mendez, C. Delgado ; Ortega, A. Diago ; Doert, M. ; Dominguez, A. ; Prester, Dijana Dominis ; Dorner, D. ; Doro, M. ; Elsaesser, D. ; Ferenc, D. ; Fonseca, M. V. ; Font, L. ; Lopen, R. J. Garcia ; Garczarczyk, M. ; Gaug, M. ; Giavitto, G. ; Godinovi, N. ; Hadasch, D. ; Herrero, A. ; Hildebrand, D. ; Hoehne-Moench, D. ; Hose, J. ; Hrupec, D. ; Jogler, T. ; Klepser, S. ; Kraehenbuehl, T. ; Kranich, D. ; Krause, J. ; La Barbera, A. ; Leonardo, E. ; Lindfors, E. ; Lombardi, S. ; Lopez, M. ; Lorenz, E. ; Majumdar, P. ; Makariev, E. ; Maneva, G. ; Mankuzhiyil, N. ; Mannheim, K. ; Maraschi, L. ; Mariotti, M. ; Martinez, M. ; Mazin, D. ; Meucci, M. ; Miranda, J. M. ; Mirzoyan, R. ; Miyamoto, H. ; Moldon, J. ; Moralejo, A. ; Nieto, D. ; Nilsson, K. ; Orito, R. ; Oya, I. ; Paoletti, R. ; Paredes, J. M. ; Partini, S. ; Pasanen, M. ; Pauss, F. ; Pegna, R. G. ; Perez-Torres, M. A. ; Persic, M. ; Peruzzo, J. ; Pochon, J. ; Moroni, P. G. Prada ; Prada, F. ; Prandini, E. ; Puchades, N. ; Puljak, I. ; Reichardt, T. ; Reinthal, R. ; Rhode, W. ; Ribo, M. ; Rico, J. ; Rissi, M. ; Ruegamer, S. ; Saggion, A. ; Saito, K. ; Saito, T. Y. ; Salvati, M. ; Sanchez-Conde, M. ; Satalecka, K. ; Scalzotto, V. ; Scapin, V. ; Schultz, C. ; Schweizer, T. ; Shayduk, M. ; Shore, S. N. ; Sierpowska-Bartosik, A. ; Sillanpaa, A. ; Sitarek, J. ; Sobczynska, D. ; Spanier, F. ; Spiro, S. ; Stamerra, A. ; Steinke, B. ; Storz, J. ; Strah, N. ; Struebig, J. C. ; Suric, T. ; Takalo, L. O. ; Tavecchio, F. ; Temnikov, P. ; Terzic, T. ; Tescaro, D. ; Teshima, M. ; Vankov, H. ; Wagner, R. M. ; Weitzel, Q. ; Zabalza, V. ; Zandanel, F. ; Zanin, R. ; Acciari, V. A. ; Arlen, T. ; Aune, T. ; Benbow, W. ; Boltuch, D. ; Bradbury, S. M. ; Buckley, J. H. ; Bugaev, V. ; Cannon, A. ; Cesarini, A. ; Ciupik, L. ; Cui, W. ; Dickherber, R. ; Errando, M. ; Falcone, A. ; Finley, J. P. ; Finnegan, G. ; Fortson, L. ; Furniss, A. ; Galante, N. ; Gall, D. ; Gillanders, G. H. ; Godambe, S. ; Grube, J. ; Guenette, R. ; Gyuk, G. ; Hanna, D. ; Holder, J. ; Huang, D. ; Hui, C. M. ; Humensky, T. B. ; Kaaret, P. ; Karlsson, N. ; Kertzman, M. ; Kieda, D. ; Konopelko, A. ; Krawczynski, H. ; Krennrich, F. ; Lang, M. J. ; Maier, G. ; McArthur, S. ; McCann, A. ; McCutcheon, M. ; Moriarty, P. ; Mukherjee, R. ; Ong, R. ; Otte, N. ; Pandel, D. ; Perkins, J. S. ; Pichel, A. ; Pohl, M. ; Quinn, J. ; Ragan, K. ; Reyes, L. C. ; Reynolds, P. T. ; Roache, E. ; Rose, H. J. ; Rovero, A. C. ; Schroedter, M. ; Sembroski, G. H. ; Senturk, G. D. ; Steele, D. ; Swordy, S. P. ; Tesic, G. ; Theiling, M. ; Thibadeau, S. ; Varlotta, A. ; Vincent, S. ; Wakely, S. P. ; Ward, J. E. ; Weekes, T. C. ; Weinstein, A. ; Weisgarber, T. ; Williams, D. A. ; Wood, M. ; Zitzer, B. ; Villata, M. ; Raiteri, C. M. ; Aller, H. D. ; Aller, M. F. ; Arkharov, A. A. ; Blinov, D. A. ; Calcidese, P. ; Chen, W. P. ; Efimova, N. V. ; Kimeridze, G. ; Konstantinova, T. S. ; Kopatskaya, E. N. ; Koptelova, E. ; Kurtanidze, O. M. ; Kurtanidze, S. O. ; Lahteenmaki, A. ; Larionov, V. M. ; Larionova, E. G. ; Larionova, L. V. ; Ligustri, R. ; Morozova, D. A. ; Nikolashvili, M. G. ; Sigua, L. A. ; Troitsky, I. S. ; Angelakis, E. ; Capalbi, M. ; Carraminana, A. ; Carrasco, L. ; Cassaro, P. ; de la Fuente, E. ; Gurwell, M. A. ; Kovalev, Y. Y. ; Kovalev, Yu. A. ; Krichbaum, T. P. ; Krimm, H. A. ; Leto, P. ; Lister, M. L. ; Maccaferri, G. ; Moody, J. W. ; Mori, Y. ; Nestoras, I. ; Orlati, A. ; Pagani, C. ; Pace, C. ; Pearson, R. ; Perri, M. ; Piner, B. G. ; Pushkarev, A. B. ; Ros, E. ; Sadun, A. C. ; Sakamoto, T. ; Tornikoski, M. ; Yatsu, Y. ; Zook, A.
We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average Large Area Telescope (LAT) gamma-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 +/- 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of two), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 +/- 0.14, and the softest one is 2.51 +/- 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3 GeV. In this paper, we also present the first results from the 4.5 month long multifrequency campaign (2009 March 15-August 1) on Mrk 501, which included the Very Long Baseline Array (VLBA), Swift, RXTE, MAGIC, and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The extensive radio to TeV data set from this campaign provides us with the most detailed spectral energy distribution yet collected for this source during its relatively low activity. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton (SSC) model. In the framework of this model, we find that the dominant emission region is characterized by a size less than or similar to 0.1 pc (comparable within a factor of few to the size of the partially resolved VLBA core at 15-43 GHz), and that the total jet power (similar or equal to 10(44) erg s(-1)) constitutes only a small fraction (similar to 10(-3)) of the Eddington luminosity. The energy distribution of the freshly accelerated radiating electrons required to fit the time-averaged data has a broken power-law form in the energy range 0.3 GeV-10 TeV, with spectral indices 2.2 and 2.7 below and above the break energy of 20 GeV. We argue that such a form is consistent with a scenario in which the bulk of the energy dissipation within the dominant emission zone of Mrk 501 is due to relativistic, proton-mediated shocks. We find that the ultrarelativistic electrons and mildly relativistic protons within the blazar zone, if comparable in number, are in approximate energy equipartition, with their energy dominating the jet magnetic field energy by about two orders of magnitude.
A novel common variant in DCST2 is associated with length in early life and height in adulthood (2015)
van der Valk, Ralf J. P. ; Kreiner-Moller, Eskil ; Kooijman, Marjolein N. ; Guxens, Monica ; Stergiakouli, Evangelia ; Saaf, Annika ; Bradfield, Jonathan P. ; Geller, Frank ; Hayes, M. Geoffrey ; Cousminer, Diana L. ; Koerner, Antje ; Thiering, Elisabeth ; Curtin, John A. ; Myhre, Ronny ; Huikari, Ville ; Joro, Raimo ; Kerkhof, Marjan ; Warrington, Nicole M. ; Pitkanen, Niina ; Ntalla, Ioanna ; Horikoshi, Momoko ; Veijola, Riitta ; Freathy, Rachel M. ; Teo, Yik-Ying ; Barton, Sheila J. ; Evans, David M. ; Kemp, John P. ; St Pourcain, Beate ; Ring, Susan M. ; Smith, George Davey ; Bergstrom, Anna ; Kull, Inger ; Hakonarson, Hakon ; Mentch, Frank D. ; Bisgaard, Hans ; Chawes, Bo Lund Krogsgaard ; Stokholm, Jakob ; Waage, Johannes ; Eriksen, Patrick ; Sevelsted, Astrid ; Melbye, Mads ; van Duijn, Cornelia M. ; Medina-Gomez, Carolina ; Hofman, Albert ; de Jongste, Johan C. ; Taal, H. Rob ; Uitterlinden, Andre G. ; Armstrong, Loren L. ; Eriksson, Johan ; Palotie, Aarno ; Bustamante, Mariona ; Estivill, Xavier ; Gonzalez, Juan R. ; Llop, Sabrina ; Kiess, Wieland ; Mahajan, Anubha ; Flexeder, Claudia ; Tiesler, Carla M. T. ; Murray, Clare S. ; Simpson, Angela ; Magnus, Per ; Sengpiel, Verena ; Hartikainen, Anna-Liisa ; Keinanen-Kiukaanniemi, Sirkka ; Lewin, Alexandra ; Alves, Alexessander Da Silva Couto ; Blakemore, Alexandra I. F. ; Buxton, Jessica L. ; Kaakinen, Marika ; Rodriguez, Alina ; Sebert, Sylvain ; Vaarasmaki, Marja ; Lakka, Timo ; Lindi, Virpi ; Gehring, Ulrike ; Postma, Dirkje S. ; Ang, Wei ; Newnham, John P. ; Lyytikainen, Leo-Pekka ; Pahkala, Katja ; Raitakari, Olli T. ; Panoutsopoulou, Kalliope ; Zeggini, Eleftheria ; Boomsma, Dorret I. ; Groen-Blokhuis, Maria ; Ilonen, Jorma ; Franke, Lude ; Hirschhorn, Joel N. ; Pers, Tune H. ; Liang, Liming ; Huang, Jinyan ; Hocher, Berthold ; Knip, Mikael ; Saw, Seang-Mei ; Holloway, John W. ; Melen, Erik ; Grant, Struan F. A. ; Feenstra, Bjarke ; Lowe, William L. ; Widen, Elisabeth ; Sergeyev, Elena ; Grallert, Harald ; Custovic, Adnan ; Jacobsson, Bo ; Jarvelin, Marjo-Riitta ; Atalay, Mustafa ; Koppelman, Gerard H. ; Pennell, Craig E. ; Niinikoski, Harri ; Dedoussis, George V. ; Mccarthy, Mark I. ; Frayling, Timothy M. ; Sunyer, Jordi ; Timpson, Nicholas J. ; Rivadeneira, Fernando ; Bonnelykke, Klaus ; Jaddoe, Vincent W. V.
Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
Comparing impacts of climate change on streamflow in four large African river basins (2014)
Aich, Valentin ; Liersch, Stefan ; Vetter, T. ; Huang, S. ; Tecklenburg, J. ; Hoffmann, P. ; Koch, H. ; Fournet, S. ; Krysanova, Valentina ; Mueller, N. ; Hattermann, Fred Fokko
This study aims to compare impacts of climate change on streamflow in four large representative African river basins: the Niger, the Upper Blue Nile, the Oubangui and the Limpopo. We set up the eco-hydrological model SWIM (Soil and Water Integrated Model) for all four basins individually. The validation of the models for four basins shows results from adequate to very good, depending on the quality and availability of input and calibration data. For the climate impact assessment, we drive the model with outputs of five bias corrected Earth system models of Coupled Model Intercomparison Project Phase 5 (CMIP5) for the representative concentration pathways (RCPs) 2.6 and 8.5. This climate input is put into the context of climate trends of the whole African continent and compared to a CMIP5 ensemble of 19 models in order to test their representativeness. Subsequently, we compare the trends in mean discharges, seasonality and hydrological extremes in the 21st century. The uncertainty of results for all basins is high. Still, climate change impact is clearly visible for mean discharges but also for extremes in high and low flows. The uncertainty of the projections is the lowest in the Upper Blue Nile, where an increase in streamflow is most likely. In the Niger and the Limpopo basins, the magnitude of trends in both directions is high and has a wide range of uncertainty. In the Oubangui, impacts are the least significant. Our results confirm partly the findings of previous continental impact analyses for Africa. However, contradictory to these studies we find a tendency for increased streamflows in three of the four basins (not for the Oubangui). Guided by these results, we argue for attention to the possible risks of increasing high flows in the face of the dominant water scarcity in Africa. In conclusion, the study shows that impact intercomparisons have added value to the adaptation discussion and may be used for setting up adaptation plans in the context of a holistic approach.
Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of ES cell-derived embryoid bodies and multicellular tumor spheroids by plant ingredients use (2003)
Wartenberg, Maria ; Budde, Paula ; de Mareés, M. ; Tsang, S. Y. ; Huang, Y. ; Chen, Zhen-Yu ; Hescheler, Jürgen ; Sauer, Heinrich
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